MMP Inhibitor II

Modify Date: 2024-01-13 17:29:31

MMP Inhibitor II Structure
MMP Inhibitor II structure
Common Name MMP Inhibitor II
CAS Number 203915-59-7 Molecular Weight 513.584
Density 1.4±0.1 g/cm3 Boiling Point N/A
Molecular Formula C21H27N3O8S2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of MMP Inhibitor II


MMP Inhibitor II (compound 4e) is a potent, reversible pan-MMP inhibitor with IC50 values of 24 nM, 18.4 nM, 30 nM, and 2.7 nM for MMP-1,MMP-3, MMP-7, and MMP-9, respectively[1].

 Names

Name N-hydroxy-1,3-bis[(4-methoxyphenyl)sulfonyl]-5,5-dimethyl-1,3-diazinane-2-carboxamide
Synonym More Synonyms

 MMP Inhibitor II Biological Activity

Description MMP Inhibitor II (compound 4e) is a potent, reversible pan-MMP inhibitor with IC50 values of 24 nM, 18.4 nM, 30 nM, and 2.7 nM for MMP-1,MMP-3, MMP-7, and MMP-9, respectively[1].
Related Catalog
Target

MMP-1:24 nM (IC50)

MMP-3:18.4 nM (IC50)

MMP-7:30 nM (IC50)

MMP-9:2.7 nM (IC50)

References

[1]. S Pikul, et al. Discovery of potent, achiral matrix metalloproteinase inhibitors. J Med Chem. 1998 Sep 10;41(19):3568-71.  

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Molecular Formula C21H27N3O8S2
Molecular Weight 513.584
Exact Mass 513.123962
PSA 162.80000
LogP 3.78
Index of Refraction 1.591

 Synonyms

N25
2-Pyrimidinecarboxamide, hexahydro-N-hydroxy-1,3-bis[(4-methoxyphenyl)sulfonyl]-5,5-dimethyl-
N-Hydroxy-1,3-bis[(4-methoxyphenyl)sulfonyl]-5,5-dimethylhexahydro-2-pyrimidinecarboxamide
1bqo
mmp inhibitor ii
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