5-Iminodaunorubicin

Modify Date: 2024-01-11 05:10:07

5-Iminodaunorubicin Structure
5-Iminodaunorubicin structure
Common Name 5-Iminodaunorubicin
CAS Number 72983-78-9 Molecular Weight 526.54
Density N/A Boiling Point N/A
Molecular Formula C27H30N2O9 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of 5-Iminodaunorubicin


5-Iminodaunorubicin is a quinone-modified anthracycline that retains antitumor activity[1]. 5-Iminodaunorubicin produces protein-concealed DNA strand breaks in cancer cells[2].

 Names

Name 5-Iminodaunorubicin

 5-Iminodaunorubicin Biological Activity

Description 5-Iminodaunorubicin is a quinone-modified anthracycline that retains antitumor activity[1]. 5-Iminodaunorubicin produces protein-concealed DNA strand breaks in cancer cells[2].
Related Catalog
In Vitro In mouse leukemia L1210 cells, 5-Iminodaunorubicin produces protein-concealed DNA strand breaks. Many of the 5-iminodaunorubicin breaks may arise from apposed single-strand breaks (i.e., double-strand breaks)[2].
In Vivo In rat, 5-Iminodaunorubicin (5-ID; 1-16 mg/kg) treatment produces widening of the QRS complex, increased R- and S-wave voltage, and prolonged the Q alpha T interval. And the quinone redox cycling is suppressed in 5-Iminodaunorubicin. 5-Iminodaunorubicin shows lower cardiotoxic[1].
References

[1]. R A Jensen, et al. Electrocardiographic and transmembrane potential effects of 5-iminodaunorubicin in the rat. Cancer Res. 1984 Sep;44(9):4030-9.

[2]. L A Zwelling, et al. Cytotoxicity and DNA strand breaks by 5-iminodaunorubicin in mouse leukemia L1210 cells: comparison with adriamycin and 4'-(9-acridinylamino)methanesulfon-m-anisidide. Cancer Res. 1982 Jul;42(7):2687-91.

 Chemical & Physical Properties

Molecular Formula C27H30N2O9
Molecular Weight 526.54