NCI-83633

Modify Date: 2025-08-25 10:39:14

NCI-83633 Structure
NCI-83633 structure
Common Name NCI-83633
CAS Number 732-85-4 Molecular Weight 256.34300
Density 1.128 g/cm3 Boiling Point 467ºC at 760 mmHg
Molecular Formula C16H20N2O Melting Point N/A
MSDS Chinese USA Flash Point 236.2ºC
Symbol GHS08
GHS08
Signal Word Warning

 Use of NCI-83633


A small molecule inhibitor of PP2C that activates extensive 3' cleavage at a concentration 50-fold below that required by fluoride or CP..

 Names

Name L-LEUCINE β-NAPHTHYLAMIDE
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.128 g/cm3
Boiling Point 467ºC at 760 mmHg
Molecular Formula C16H20N2O
Molecular Weight 256.34300
Flash Point 236.2ºC
Exact Mass 256.15800
PSA 55.12000
LogP 3.92500
Index of Refraction 1.625
InChIKey JWHURRLUBVMKOT-HNNXBMFYSA-N
SMILES CC(C)CC(N)C(=O)Nc1ccc2ccccc2c1
Storage condition 20°C

 Safety Information

Symbol GHS08
GHS08
Signal Word Warning
Hazard Statements H351
Precautionary Statements P281
Personal Protective Equipment Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes Xn: Harmful;
Risk Phrases R40
Safety Phrases 22-36
RIDADR NONH for all modes of transport

 Synthetic Route

~%

NCI-83633 Structure

NCI-83633

CAS#:732-85-4

Literature: Tuppy; Nesvadba Monatshefte fuer Chemie, 1957 , vol. 88, p. 977,983

~%

NCI-83633 Structure

NCI-83633

CAS#:732-85-4

Literature: Tuppy; Nesvadba Monatshefte fuer Chemie, 1957 , vol. 88, p. 977,983

~%

NCI-83633 Structure

NCI-83633

CAS#:732-85-4

Literature: Green et al. Archives of Biochemistry, 1955 , vol. 57, p. 458,460

 Articles14

More Articles
[Changes in the aminopeptidase activity in the brain neurons of rats subjected long-term to alcoholic intoxication].

Tsitologiia 32(10) , 1006-9, (1990)

A histochemical investigation was made of aminopeptidase activities using L-leucine-beta-naphthylamide and D, L-alanine-beta-naphthylamine as respective substrates in the rat's sensomotor cortex neuro...

Subcellular distribution of soluble and membrane-bound Leu-, Arg- and Asp-beta-naphthylamide-hydrolysing activities in rat brain.

Cell Mol. Biol. 36(2) , 175-9, (1990)

Subcellular distribution of soluble and membrane-bound Leu-, Arg- and Asp-beta-naphthylamide hydrolysing activities (arylamidase activity) was studied from left and right rat brains, each including he...

The aminopeptidase N-encoding pepN gene of Streptomyces lividans 66.

Gene 141(1) , 115-9, (1994)

The gene (pepN) encoding an aminopeptidase N (PepN) has been cloned from Streptomyces lividans. This was done using either leucine-beta-naphthylamide or arginine-beta-naphthylamide in a liquid overlay...

 NCI-83633Bioassay

View more

Name: Lysozyme-conjugated prodrugs: in vitro stability at pH 5
Source: ChEMBL
Target: Rattus norvegicus
External Id: CHEMBL801909
Name: Lysozyme-conjugated prodrugs: in vitro stability at pH 7.4
Source: ChEMBL
Target: Rattus norvegicus
External Id: CHEMBL801907
Name: Lysozyme-conjugated prodrugs: in vitro stability at pH 5
Source: ChEMBL
Target: Rattus norvegicus
External Id: CHEMBL803510
Name: Lysozyme-conjugated prodrugs: in vitro stability at pH 7.4
Source: ChEMBL
Target: Rattus norvegicus
External Id: CHEMBL797903
Name: Lysozyme-conjugated prodrugs: in vitro stability at pH 5
Source: ChEMBL
Target: Rattus norvegicus
External Id: CHEMBL801905
Name: Lysozyme-conjugated prodrugs: in vitro stability at pH 7.4
Source: ChEMBL
Target: Rattus norvegicus
External Id: CHEMBL803512
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 Synonyms

H-LEU-BETANA
LEUCINE-BETANA
H-Leu-bNA
L-Leucin-[2]naphthylamid
(S)-2-amino-4-methyl-pentanoic acid naphthalene-2-ylamide
L-Leu-NNap
L-LEUCINE-2-NAPHTHYLAMIDE
EINECS 211-990-0
MFCD00055914
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