Z-Leu-OH

Modify Date: 2024-01-02 10:54:48

Z-Leu-OH Structure
Z-Leu-OH structure
Common Name Z-Leu-OH
CAS Number 2018-66-8 Molecular Weight 265.305
Density 1.2±0.1 g/cm3 Boiling Point 442.8±38.0 °C at 760 mmHg
Molecular Formula C14H19NO4 Melting Point N/A
MSDS Chinese USA Flash Point 221.6±26.8 °C
Symbol GHS02 GHS08
GHS02, GHS08
Signal Word Warning

 Use of Z-Leu-OH


N-[(Phenylmethoxy)carbonyl]-L-leucine is a leucine derivative[1].

 Names

Name N-benzyloxycarbonyl-L-leucine
Synonym More Synonyms

 Z-Leu-OH Biological Activity

Description N-[(Phenylmethoxy)carbonyl]-L-leucine is a leucine derivative[1].
Related Catalog
In Vitro Amino acids and amino acid derivatives have been commercially used as ergogenic supplements. They influence the secretion of anabolic hormones, supply of fuel during exercise, mental performance during stress related tasks and prevent exercise induced muscle damage. They are recognized to be beneficial as ergogenic dietary substances[1].
References

[1]. Luckose F, et al. Effects of amino acid derivatives on physical, mental, and physiological activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-1144.

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 442.8±38.0 °C at 760 mmHg
Molecular Formula C14H19NO4
Molecular Weight 265.305
Flash Point 221.6±26.8 °C
Exact Mass 265.131409
PSA 75.63000
LogP 3.12
Vapour Pressure 0.0±1.1 mmHg at 25°C
Index of Refraction 1.528
Storage condition 2~8°C

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
OH2921000
CHEMICAL NAME :
Leucine, N-carboxy-, N-benzyl ester, L-
CAS REGISTRY NUMBER :
2018-66-8
BEILSTEIN REFERENCE NO. :
1253861
LAST UPDATED :
199612
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C14-H19-N-O4
MOLECULAR WEIGHT :
265.34

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravaginal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 68,696,1979 ** REPRODUCTIVE DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravaginal
DOSE :
280 mg/kg
SEX/DURATION :
female 28 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated)
REFERENCE :
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 68,696,1979

 Safety Information

Symbol GHS02 GHS08
GHS02, GHS08
Signal Word Warning
Hazard Statements H226-H351-H361d
Precautionary Statements P281
Personal Protective Equipment Eyeshields;Gloves
Hazard Codes Xn:Harmful
Risk Phrases R10;R20/22;R37/38;R40;R41
Safety Phrases S16-S26-S36/37/39-S45
RIDADR UN 1993 3/PG 3
WGK Germany 3
RTECS OH2921000
HS Code 2924299090

 Customs

HS Code 2924299090
Summary 2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

 Synonyms

N-[(Benzyloxy)carbonyl]-L-leucine
N-(Benzyloxycarbonyl)-L-leucine (N-(Benzyloxycarbonyl)leucine
Z-L-Leucine
EINECS 217-960-3
N-Carbobenzyloxy-L-leucine
(2S)-4-methyl-2-(phenylmethoxycarbonylamino)pentanoic acid
N-Benzyloxycarbonyl-L-leucine
Cbz-L-Leu-OH
Carbobenzoxyleucine
Benzyloxycarbonylleucine
dl-Leucine, N-[(phenylmethoxy)carbonyl]-
N-(Benzyloxycarbonyl)-L-leucine N-(B
(S)-2-(((Benzyloxy)carbonyl)amino)-4-methylpentanoic acid
Z-Leu-OH
N-Benzyloxycarbonylleucine
L-Leucine, N-[(phenylmethoxy)carbonyl]-
N-Cbz-L-leucine
N-[(Benzyloxy)carbonyl]leucine
MFCD00026494
Cbz-L-leucine
Leucine, N-[(phenylmethoxy)carbonyl]-
Benzyloxycarbonyl-L-leucine
N-Carbobenzoxy-L-leucine
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