2-DEMETHYLCOLCHICINE

Modify Date: 2025-08-27 14:42:58

2-DEMETHYLCOLCHICINE Structure
2-DEMETHYLCOLCHICINE structure
 Common Name 2-DEMETHYLCOLCHICINE
CAS Number 7336-36-9 Molecular Weight 385.41000
Density 1.31g/cm3 Boiling Point 766.1ºC at 760mmHg
Molecular Formula C21H23NO6 Melting Point N/A
MSDS N/A Flash Point 417.1ºC

 Names

Name 2-demethylcolchicine
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.31g/cm3
Boiling Point 766.1ºC at 760mmHg
Molecular Formula C21H23NO6
Molecular Weight 385.41000
Flash Point 417.1ºC
Exact Mass 385.15300
PSA 94.09000
LogP 2.95950
InChIKey DPOVAJCRYIUTBD-HNNXBMFYSA-N
SMILES COc1cc2c(c(OC)c1O)-c1ccc(OC)c(=O)cc1C(NC(C)=O)CC2

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
GH0880000
CHEMICAL NAME :
Colchicine, O(sup 2)-demethyl-
CAS REGISTRY NUMBER :
7336-36-9
LAST UPDATED :
199409
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C21-H23-N-O6
MOLECULAR WEIGHT :
385.45
WISWESSER LINE NOTATION :
L B677 MV&T&J CO1 DO1 EO1 JMV1 NO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intracerebral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
75 ug/kg
TOXIC EFFECTS :
Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - excitement
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 109,386,1957
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
19 mg/kg
TOXIC EFFECTS :
Behavioral - food intake (animal) Behavioral - muscle weakness Gastrointestinal - hypermotility, diarrhea
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 94,453,1953
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
16 mg/kg
TOXIC EFFECTS :
Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - excitement
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 109,386,1957
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intramuscular
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
16577 ug/kg
TOXIC EFFECTS :
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 24,257,1981

 Synthetic Route

Colchicine structure

Colchicine

CAS#:64-86-8

~46%

2-DEMETHYLCOLCHICINE Structure

2-DEMETHYLCOLCHICINE

CAS#:7336-36-9

Literature: Roesner, Manfred; Capraro, Hans-Georg; Jacobson, Arthur E.; Atwell, Louise; Brossi, Arnold; et al. Journal of Medicinal Chemistry, 1981 , vol. 24, # 3 p. 257 - 261
Colchicine structure

Colchicine

CAS#:64-86-8

~18%

2-DEMETHYLCOLCHICINE Structure

2-DEMETHYLCOLCHICINE

CAS#:7336-36-9

Acetamide,N-[(7S)-5,6,7,9-tetrahydro-2,3-dihydroxy-1,10-dimethoxy-9-oxobenzo[a]heptalen-7-yl] structure

Acetamide,N-[(7...

CAS#:57866-21-4

1, 2-Didemethylcolchicine structure

1, 2-Didemethyl...

CAS#:78231-83-1

Literature: Kitajima, Mariko; Tanaka, Akiko; Kogure, Noriyuki; Takayama, Hiromitsu Tetrahedron Letters, 2008 , vol. 49, # 2 p. 257 - 260
Colchicine structure

Colchicine

CAS#:64-86-8

~%

2-DEMETHYLCOLCHICINE Structure

2-DEMETHYLCOLCHICINE

CAS#:7336-36-9

1, 2-Didemethylcolchicine structure

1, 2-Didemethyl...

CAS#:78231-83-1

Literature: Roesner, Manfred; Hsu, Fu-Lian; Brossi, Arnold Journal of Organic Chemistry, 1981 , vol. 46, # 18 p. 3686 - 3688
diazomethane structure

diazomethane

CAS#:186581-53-3

N-[(7S)-2,10-dihydroxy-1,3-dimethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide structure

N-[(7S)-2,10-di...

CAS#:33530-04-0

~%

Colchicine structure

Colchicine

CAS#:64-86-8

2-DEMETHYLCOLCHICINE Structure

2-DEMETHYLCOLCHICINE

CAS#:7336-36-9

Detail
Literature: Chommadov, B. Ch.; Yusupov, M. K.; Aslanov, Kh. A. Chemistry of Natural Compounds, 1991 , vol. 27, # 1 p. 58 - 61 Khimiya Prirodnykh Soedinenii, 1991 , # 1 p. 67 - 71

 Synonyms

O2-Demethylcolchicin
2-O-demethylcolchicine
3-demethylcolchicine
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