2-DEMETHYLCOLCHICINE

Modify Date: 2025-08-27 14:42:58

2-DEMETHYLCOLCHICINE Structure
2-DEMETHYLCOLCHICINE structure
 Common Name 2-DEMETHYLCOLCHICINE
CAS Number 7336-36-9 Molecular Weight 385.41000
Density 1.31g/cm3 Boiling Point 766.1ºC at 760mmHg
Molecular Formula C21H23NO6 Melting Point N/A
MSDS N/A Flash Point 417.1ºC

 Names

Name 2-demethylcolchicine
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.31g/cm3
Boiling Point 766.1ºC at 760mmHg
Molecular Formula C21H23NO6
Molecular Weight 385.41000
Flash Point 417.1ºC
Exact Mass 385.15300
PSA 94.09000
LogP 2.95950
InChIKey DPOVAJCRYIUTBD-HNNXBMFYSA-N
SMILES COc1cc2c(c(OC)c1O)-c1ccc(OC)c(=O)cc1C(NC(C)=O)CC2

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
GH0880000
CHEMICAL NAME :
Colchicine, O(sup 2)-demethyl-
CAS REGISTRY NUMBER :
7336-36-9
LAST UPDATED :
199409
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C21-H23-N-O6
MOLECULAR WEIGHT :
385.45
WISWESSER LINE NOTATION :
L B677 MV&T&J CO1 DO1 EO1 JMV1 NO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intracerebral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
75 ug/kg
TOXIC EFFECTS :
Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - excitement
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 109,386,1957
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
19 mg/kg
TOXIC EFFECTS :
Behavioral - food intake (animal) Behavioral - muscle weakness Gastrointestinal - hypermotility, diarrhea
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 94,453,1953
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
16 mg/kg
TOXIC EFFECTS :
Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - excitement
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 109,386,1957
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intramuscular
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
16577 ug/kg
TOXIC EFFECTS :
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 24,257,1981

 Synthetic Route

Colchicine structure

Colchicine

CAS#:64-86-8

~46%

2-DEMETHYLCOLCHICINE Structure

2-DEMETHYLCOLCHICINE

CAS#:7336-36-9

Literature: Roesner, Manfred; Capraro, Hans-Georg; Jacobson, Arthur E.; Atwell, Louise; Brossi, Arnold; et al. Journal of Medicinal Chemistry, 1981 , vol. 24, # 3 p. 257 - 261
Colchicine structure

Colchicine

CAS#:64-86-8

~18%

2-DEMETHYLCOLCHICINE Structure

2-DEMETHYLCOLCHICINE

CAS#:7336-36-9

Acetamide,N-[(7S)-5,6,7,9-tetrahydro-2,3-dihydroxy-1,10-dimethoxy-9-oxobenzo[a]heptalen-7-yl] structure

Acetamide,N-[(7...

CAS#:57866-21-4

1, 2-Didemethylcolchicine structure

1, 2-Didemethyl...

CAS#:78231-83-1

Literature: Kitajima, Mariko; Tanaka, Akiko; Kogure, Noriyuki; Takayama, Hiromitsu Tetrahedron Letters, 2008 , vol. 49, # 2 p. 257 - 260
Colchicine structure

Colchicine

CAS#:64-86-8

~%

2-DEMETHYLCOLCHICINE Structure

2-DEMETHYLCOLCHICINE

CAS#:7336-36-9

1, 2-Didemethylcolchicine structure

1, 2-Didemethyl...

CAS#:78231-83-1

Literature: Roesner, Manfred; Hsu, Fu-Lian; Brossi, Arnold Journal of Organic Chemistry, 1981 , vol. 46, # 18 p. 3686 - 3688
diazomethane structure

diazomethane

CAS#:186581-53-3

N-[(7S)-2,10-dihydroxy-1,3-dimethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide structure

N-[(7S)-2,10-di...

CAS#:33530-04-0

~%

Colchicine structure

Colchicine

CAS#:64-86-8

2-DEMETHYLCOLCHICINE Structure

2-DEMETHYLCOLCHICINE

CAS#:7336-36-9

Detail
Literature: Chommadov, B. Ch.; Yusupov, M. K.; Aslanov, Kh. A. Chemistry of Natural Compounds, 1991 , vol. 27, # 1 p. 58 - 61 Khimiya Prirodnykh Soedinenii, 1991 , # 1 p. 67 - 71

 Synonyms

O2-Demethylcolchicin
2-O-demethylcolchicine
3-demethylcolchicine
The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.
Top Suppliers:I want be here

Get all suppliers and price by the below link:

2-DEMETHYLCOLCHICINE suppliers

2-DEMETHYLCOLCHICINE price

Related Compounds: More...
N-([1,3]dioxolo[4,5-f][1,3]benzothiazol-6-yl)-2-(2,5-dioxopyrrolidin-1-yl)acetamide
892851-42-2
N-(5-(2-((4-fluorophenyl)thio)acetyl)-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)-5-methylisoxazole-3-carboxamide
1396851-44-7
1-((3-chlorophenyl)sulfonyl)-3-(3-methoxypropyl)-2,3-dihydro-1H-imidazo[4,5-b]quinoxaline
847335-95-9
10-(1,3-benzodioxol-5-yl)-5H-benzo[c]furo[3,2-g]chromen-5-one
374760-18-6
N-(3,4-dichlorophenyl)-N'-methyl-N'-phenylpropanediamide
338392-29-3
3-(2,4-Dichlorobenzamido)benzofuran-2-carboxamide
477511-20-9
8-(4-benzylpiperazin-1-yl)-7-(2-ethoxyethyl)-3-methyl-1H-purine-2,6(3H,7H)-dione
442557-92-8
2-(3,5-dimethyl-4-nitropyrazol-1-yl)-N-[(E)-(5-methylfuran-2-yl)methylideneamino]acetamide
714941-31-8
6-chloro-3-(4-fluorophenyl)-2-methyl-5-propylpyrazolo[1,5-a]pyrimidin-7(4H)-one
879617-55-7
Etryptamine, (R)
10215-73-3
Chemsrc provides 2-DEMETHYLCOLCHICINE(CAS#:7336-36-9) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of 2-DEMETHYLCOLCHICINE are included as well.>> amp version: 2-DEMETHYLCOLCHICINE

Home | MSDS/SDS Database Search | Journals | Product Classification | Biologically Active Compounds | Selling Leads | About Us | Disclaimer

Copyright © 2026 ChemSrc All Rights Reserved