(-)-Bicuculline methobromide
Modify Date: 2026-07-05 05:05:06
(-)-Bicuculline methobromide structure
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Common Name | (-)-Bicuculline methobromide | ||
|---|---|---|---|---|
| CAS Number | 73604-30-5 | Molecular Weight | 462.29100 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C21H20BrNO6 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of (-)-Bicuculline methobromide(-)-Bicuculline methobromide (l-Bicuculline methobromide) is a potent GABAA receptor antagonist. (-)-Bicuculline methobromide blocks afterhyperpolarizations (AHPs) mediated by Ca2+-activated K+ channels in various types of neurons[1]. |
| Name | 6-(6,6-dimethyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-6-ium-5-yl)-6H-furo[3,4-g][1,3]benzodioxol-8-one,bromide |
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| Synonym | More Synonyms |
| Description | (-)-Bicuculline methobromide (l-Bicuculline methobromide) is a potent GABAA receptor antagonist. (-)-Bicuculline methobromide blocks afterhyperpolarizations (AHPs) mediated by Ca2+-activated K+ channels in various types of neurons[1]. |
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| Related Catalog | |
| Target |
GABAA[1] |
| In Vivo | (-)-Bicuculline methobromide (0.6 nmol/rat) attenuates the antiallodynic effect of Neurotropin[2]. Animal Model: Rat L5-SNL model[2] Dosage: 0.6 nmol/rat Administration: Intrathecal injection, 5 minutes before administration of Neurotropin (100 NU/kg, i.v.) Result: Attenuated the antiallodynic effect of Neurotropin. |
| References |
| Molecular Formula | C21H20BrNO6 |
|---|---|
| Molecular Weight | 462.29100 |
| Exact Mass | 461.04700 |
| PSA | 63.22000 |
| InChIKey | BWXCECYGGMGBHD-UHFFFAOYSA-M |
| SMILES | C[N+]1(C)CCc2cc3c(cc2C1C1OC(=O)c2c1ccc1c2OCO1)OCO3.[Br-] |
| Safety Phrases | S24/25 |
|---|---|
| RIDADR | UN 1544 6.1/PG 2 |
| Packaging Group | III |
| Hazard Class | 6.1(b) |
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Name: qHTS for Inhibitors of Polymerase Iota
Source: NCGC
Target: DNA polymerase iota [Homo sapiens]
External Id: PolI100
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Name: A screen for compounds that inhibit growth of Escherichia coli
Source: ICCB-Longwood/NSRB Screening Facility, Harvard Medical School
Target: N/A
External Id: HMS1158_MLP
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Name: qHTS for Inhibitors of Polymerase Eta
Source: NCGC
Target: DNA polymerase eta [Homo sapiens]
External Id: PolE100
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Name: Quantitative high throughput screen for delayed death inhibitors of the malarial para...
Source: NCGC
Target: N/A
External Id: DDV248
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Name: qHTS Assay for Small Molecule Inhibitors of the Human hERG Channel Activity
Source: NCGC
External Id: HERG01
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Name: A screen for compounds that are lethal to S. aureus RN4220
Source: ICCB-Longwood/NSRB Screening Facility, Harvard Medical School
Target: N/A
External Id: HMS1364-MLP_WT
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|
Name: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1):...
Source: NCGC
Target: thioredoxin reductase [Rattus norvegicus]
External Id: TRXR100
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|
Name: Quantitative high throughput screen for delayed death inhibitors of the malarial para...
Source: NCGC
Target: N/A
External Id: DDV296
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|
Name: Validation screen for small molecules that induce DNA re-replication in MCF 10A norma...
Source: NCGC
Target: geminin [Homo sapiens]
External Id: NUC309
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Name: A screen for compounds that are lethal to S. aureus RN4220 with the processive glycos...
Source: ICCB-Longwood/NSRB Screening Facility, Harvard Medical School
Target: N/A
External Id: HMS1364-MLP_ugtP
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