Chloromethane

Modify Date: 2026-06-30 19:34:37

Chloromethane Structure
Chloromethane structure
 Common Name Chloromethane
CAS Number 74-87-3 Molecular Weight 50.487
Density 0.9±0.1 g/cm3 Boiling Point -24.5±3.0 °C at 760 mmHg
Molecular Formula CH3Cl Melting Point -97ºC
MSDS Chinese USA Flash Point -86.4±2.8 °C
Symbol GHS02 GHS07 GHS08
GHS02, GHS07, GHS08		 Signal Word Danger

 Names

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name ([(5-chlorothien-2-yl)methyl]thio)acetic acid
Synonym More Synonyms

 Chemical & Physical Properties

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Density 0.9±0.1 g/cm3
Boiling Point -24.5±3.0 °C at 760 mmHg
Melting Point -97ºC
Molecular Formula CH3Cl
Molecular Weight 50.487
Flash Point -86.4±2.8 °C
Exact Mass 49.992329
LogP 0.97
Vapour density 1.74 (vs air)
Vapour Pressure 4074.1±0.0 mmHg at 25°C
Index of Refraction 1.331
InChIKey NEHMKBQYUWJMIP-UHFFFAOYSA-N
SMILES CCl

 MSDS

This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.

 Toxicological Information

This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.

CHEMICAL IDENTIFICATION

RTECS NUMBER :
PA6300000
CHEMICAL NAME :
Methane, chloro-
CAS REGISTRY NUMBER :
74-87-3
LAST UPDATED :
199806
DATA ITEMS CITED :
70
MOLECULAR FORMULA :
C-H3-Cl
MOLECULAR WEIGHT :
50.49
WISWESSER LINE NOTATION :
G1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Human
DOSE/DURATION :
20000 ppm/2H
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - convulsions or effect on seizure threshold Gastrointestinal - nausea or vomiting
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1800 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
5300 mg/m3/4H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
2200 ppm/6H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
14661 ppm/6H
TOXIC EFFECTS :
Vascular - BP lowering not characterized in autonomic section Lungs, Thorax, or Respiration - respiratory depression Nutritional and Gross Metabolic - body temperature increase
TYPE OF TEST :
LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Mammal - cat
DOSE/DURATION :
129 mg/m3/4H
TOXIC EFFECTS :
Behavioral - general anesthetic Lungs, Thorax, or Respiration - respiratory depression
TYPE OF TEST :
LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
20000 ppm/2H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
3000 ppm/6H/5D-I
TOXIC EFFECTS :
Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - changes in testicular weight
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
41 mg/m3/4H/26W-I
TOXIC EFFECTS :
Liver - liver function tests impaired Blood - changes in erythrocyte (RBC) count Nutritional and Gross Metabolic - weight loss or decreased weight gain
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
150 ppm/22H/11D-C
TOXIC EFFECTS :
Behavioral - changes in motor activity (specific assay) Endocrine - changes in thymus weight Related to Chronic Data - death
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
500 ppm/24H/3D-C
TOXIC EFFECTS :
Brain and Coverings - other degenerative changes Behavioral - tremor Behavioral - ataxia
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
DOSE :
2000 ppm/6H
SEX/DURATION :
male 5 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
DOSE :
1500 ppm/6H
SEX/DURATION :
male 50 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
DOSE :
1500 ppm/6H
SEX/DURATION :
female 7-19 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
DOSE :
3000 ppm/6H
SEX/DURATION :
male 5 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
DOSE :
3000 ppm/6H
SEX/DURATION :
male 5 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females)
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
DOSE :
500 ppm/6H
SEX/DURATION :
female 6-17 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - cardiovascular (circulatory) system
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
DOSE :
750 ppm/6H
SEX/DURATION :
female 6-17 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetal death
TYPE OF TEST :
Dominant lethal test

MUTATION DATA

TYPE OF TEST :
Morphological transformation
TEST SYSTEM :
Rodent - hamster Embryo
REFERENCE :
EVSRBT Environmental Science Research. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) V.1- 1972- Volume(issue)/page/year: 25,75,1982 *** REVIEWS *** ACGIH TLV-Not classifiable as a human carcinogen DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-STEL 207 mg/m3 (100 ppm) (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 103 mg/m3 (50 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 41,161,1986 IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 41,161,1986 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,246,1987 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD:air-CL 100 ppm (210 mg/m3) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,160,1971 OSHA PEL (Gen Indu):8H TWA 100 ppm;CL 200;Pk 300/5M/3H CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 100 ppm (210 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 100 ppm (210 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):CL 100 ppm (210 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-ARAB Republic of Egypt:TWA 50 ppm (105 mg/m3) JAN 1993 OEL-AUSTRALIA:TWA 50 ppm (105 mg/m3);STEL 100 ppm (205 mg/m3) JAN 1993 OEL-AUSTRIA:TWA 50 ppm (105 mg/m3) JAN 1993 OEL-BELGIUM:TWA 50 ppm (103 mg/m3);STEL 100 ppm (207 mg/m3) JAN 1993 OEL-DENMARK:TWA 50 ppm (105 mg/m3) JAN 1993 OEL-FINLAND:TWA 50 ppm (105 mg/m3);STEL 75 ppm (160 mg/m3) JAN 1993 OEL-FRANCE:TWA 50 ppm (105 mg/m3);STEL 100 ppm (210 mg/m3) JAN 1993 OEL-GERMANY:TWA 50 ppm (105 mg/m3);Carcinogen JAN 1993 OEL-HUNGARY:TWA 20 mg/m3;STEL 40 mg/m3 JAN 1993 OEL-JAPAN:TWA 50 ppm (100 mg/m3) JAN 1993 OEL-THE NETHERLANDS:TWA 50 ppm (105 mg/m3) JAN 1993 OEL-THE PHILIPPINES:TWA 100 ppm (210 mg/m3) JAN 1993 OEL-POLAND:TWA 20 mg/m3 JAN 1993 OEL-RUSSIA:TWA 50 ppm;STEL 5 mg/m3 JAN 1993 OEL-SWEDEN:TWA 50 ppm (100 mg/m3);STEL 100 ppm (200 mg/m3) JAN 1993 OEL-SWITZERLAND:TWA 50 ppm (105 mg/m3);STEL 100 ppm (210 mg/m3) JAN 1993 OEL-THAILAND:TWA 100 mg/m3;STEL 200 mg/m3 JAN 1993 OEL-TURKEY:TWA 100 ppm (210 mg/m3) JAN 1993 OEL-UNITED KINGDOM:TWA 50 ppm (105 mg/m3);STEL 100 ppm JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO METHYL CHLORIDE-air:CA lowest feasible concentration REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M0421 No. of Facilities: 1937 (estimated) No. of Industries: 32 No. of Occupations: 29 No. of Employees: 8804 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M0421 No. of Facilities: 596 (estimated) No. of Industries: 18 No. of Occupations: 38 No. of Employees: 10003 (estimated) No. of Female Employees: 571 (estimated)

 Safety Information

This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.

Symbol GHS02 GHS07 GHS08
GHS02, GHS07, GHS08
Signal Word Danger
Hazard Statements H225-H315-H351-H361fd
Supplemental HS May form explosive peroxides., Repeated exposure may cause skin dryness or cracking.
Precautionary Statements P210-P281
Personal Protective Equipment Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes F+;Xn
Risk Phrases R12
Safety Phrases 9-16-33
RIDADR UN 1993 3
WGK Germany 2
RTECS PA6300000
Hazard Class 2.1
HS Code 2903110000

 Customs

This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.

HS Code 2903110000
Summary 2903110000 chloroethane。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。Lowest tariff:5.5%。General tariff:30.0%

 Articles63

More Articles

This table lists relevant public references with title, journal and publication metadata for this compound.

Nox2-dependent glutathionylation of endothelial NOS leads to uncoupled superoxide production and endothelial barrier dysfunction in acute lung injury.

Am. J. Physiol. Lung Cell. Mol. Physiol. 307(12) , L987-97, (2014)

Microvascular barrier integrity is dependent on bioavailable nitric oxide (NO) produced locally by endothelial NO synthase (eNOS). Under conditions of limited substrate or cofactor availability or by ...

Effects of nitric oxide synthase deficiency on a disintegrin and metalloproteinase domain-containing protein 12 expression in mouse brain samples.

Mol. Med. Report. 12 , 2253-62, (2015)

A disintegrin and metalloproteinase domain-containing protein 12 (ADAM12) belongs to the ADAM family of transmembrane proteins. Via proteolysis, cell adhesion, cell-cell fusion, cell-matrix interactio...

Theoretical and experimental studies of the dechlorination mechanism of carbon tetrachloride on a vivianite ferrous phosphate surface.

J. Phys. Chem. A 119 , 5714-22, (2015)

Chlorinated organics are the principal and most frequently found contaminants in soil and groundwater, generating significant environmental problems. Over the past several decades, Fe-containing miner...

 Synonyms

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

Artic
Freon 40
EINECS 200-817-4
METHYL CHLORIDE
MFCD00000872
MONOCHLOROMETHANE
Chloride, Methyl
Chloromethane

 Chloromethane | FAQ

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What is the LogP of ([(5-chlorothien-2-yl)methyl]thio)acetic acid?
A: LogP of ([(5-chlorothien-2-yl)methyl]thio)acetic acid is 0.97.
Q: What are the downstream products of ([(5-chlorothien-2-yl)methyl]thio)acetic acid?
A: Related downstream products(CAS) of ([(5-chlorothien-2-yl)methyl]thio)acetic acid: 64-17-5;925-93-9;1111-89-3;74-89-5;34557-54-5;10574-37-5;24910-63-2;105701-76-6;40872-87-5.
Q: What is the English name of ([(5-chlorothien-2-yl)methyl]thio)acetic acid?
A: The English name of ([(5-chlorothien-2-yl)methyl]thio)acetic acid is ([(5-chlorothien-2-yl)methyl]thio)acetic acid.
Q: What is the molecular formula of ([(5-chlorothien-2-yl)methyl]thio)acetic acid?
A: Molecular formula of ([(5-chlorothien-2-yl)methyl]thio)acetic acid is CH3Cl.
Q: What is the CAS number of ([(5-chlorothien-2-yl)methyl]thio)acetic acid?
A: CAS number of ([(5-chlorothien-2-yl)methyl]thio)acetic acid is 74-87-3.
Q: What English synonyms does ([(5-chlorothien-2-yl)methyl]thio)acetic acid have?
A: English synonyms of ([(5-chlorothien-2-yl)methyl]thio)acetic acid: Artic, Freon 40, EINECS 200-817-4, METHYL CHLORIDE, MFCD00000872, MONOCHLOROMETHANE, Chloride, Methyl, Chloromethane.
Q: What is the melting point of ([(5-chlorothien-2-yl)methyl]thio)acetic acid?
A: Melting point of ([(5-chlorothien-2-yl)methyl]thio)acetic acid is -97ºC.
Q: What is the molecular weight of ([(5-chlorothien-2-yl)methyl]thio)acetic acid?
A: Molecular weight of ([(5-chlorothien-2-yl)methyl]thio)acetic acid is 50.487.
Q: What is the safety information for ([(5-chlorothien-2-yl)methyl]thio)acetic acid?
A: Safety information for ([(5-chlorothien-2-yl)methyl]thio)acetic acid: 9-16-33.
Q: What is the SMILES notation of ([(5-chlorothien-2-yl)methyl]thio)acetic acid?
A: SMILES notation of ([(5-chlorothien-2-yl)methyl]thio)acetic acid is CCl.

 Chloromethanefactory

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Shanghai Nianxing Industrial Co., Ltd
Dayang Chem (Hangzhou) Co., Ltd.
Henan Tianfu Chemical Co., Ltd.
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Chemsrc provides Chloromethane(CAS#:74-87-3) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Chloromethane are included as well.>> amp version: Chloromethane

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