4-Hydroxyphenyl-dimethyl-phenylsilan

Modify Date: 2024-02-27 18:09:02

4-Hydroxyphenyl-dimethyl-phenylsilan Structure
4-Hydroxyphenyl-dimethyl-phenylsilan structure
 Common Name 4-Hydroxyphenyl-dimethyl-phenylsilan
CAS Number 74027-99-9 Molecular Weight 228.36200
Density N/A Boiling Point N/A
Molecular Formula C14H16OSi Melting Point N/A
MSDS N/A Flash Point N/A

 Use of 4-Hydroxyphenyl-dimethyl-phenylsilan


Estrogen receptor-IN-1 (compound 16) is a potent estrogen receptor (ER) inhibitor with IC50s of 13, 5µM for ERα and Erβ, respectively[1].

 Names

Name 4-Hydroxyphenyl-dimethyl-phenylsilan
Synonym More Synonyms

 4-Hydroxyphenyl-dimethyl-phenylsilan Biological Activity

Description Estrogen receptor-IN-1 (compound 16) is a potent estrogen receptor (ER) inhibitor with IC50s of 13, 5µM for ERα and Erβ, respectively[1].
Related Catalog
Target

ERα:13 μM (IC50)

ERβ:5 μM (IC50)

References

[1]. Saito H, et al. Phosphine boranes as less hydrophobic building blocks than alkanes and silanes: Structure-property relationship and estrogen-receptor-modulating potency of 4-phosphinophenol derivatives. Bioorg Med Chem. 2020 Feb 15;28(4):115310.

 Chemical & Physical Properties

Molecular Formula C14H16OSi
Molecular Weight 228.36200
Exact Mass 228.09700
PSA 20.23000
LogP 2.21480
InChIKey QXIQBDCQUFEYPC-UHFFFAOYSA-N
SMILES C[Si](C)(c1ccccc1)c1ccc(O)cc1

 Synonyms

4-phenyldimethylsilylphenole
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