Albendazole sulfone

Modify Date: 2024-01-14 14:08:17

Albendazole sulfone structure	Common Name	Albendazole sulfone
	CAS Number	75184-71-3	Molecular Weight	297.33000
	Density	1.42g/cm3	Boiling Point	N/A
	Molecular Formula	C₁₂H₁₅N₃O₄S	Melting Point	290-292ºC
	MSDS	Chinese USA	Flash Point	N/A
	Symbol	GHS07, GHS08	Signal Word	Warning

Use of Albendazole sulfone

Albendazole sulfone is a metabolite of Albendazole, and exhibits anti-parasite effect against Echinococcus multilocularis Metacestodes[1][2].

Name	Albendazole sulfone
Synonym	More Synonyms

Description	Albendazole sulfone is a metabolite of Albendazole, and exhibits anti-parasite effect against Echinococcus multilocularis Metacestodes[1][2].
Related Catalog	Research Areas >> Infection
References	[1]. Ingold K, et, al. Efficacies of albendazole sulfoxide and albendazole sulfone against In vitro-cultivated Echinococcus multilocularis metacestodes. Antimicrob Agents Chemother. 1999 May;43(5):1052-61. [2]. Adas G, et, al. Use of albendazole sulfoxide, albendazole sulfone, and combined solutions as scolicidal agents on hydatid cysts (in vitro study). World J Gastroenterol. 2009 Jan 7;15(1):112-6.

Description

Albendazole sulfone is a metabolite of Albendazole, and exhibits anti-parasite effect against Echinococcus multilocularis Metacestodes[1][2].

Related Catalog

Research Areas >> Infection

References

[1]. Ingold K, et, al. Efficacies of albendazole sulfoxide and albendazole sulfone against In vitro-cultivated Echinococcus multilocularis metacestodes. Antimicrob Agents Chemother. 1999 May;43(5):1052-61.

[2]. Adas G, et, al. Use of albendazole sulfoxide, albendazole sulfone, and combined solutions as scolicidal agents on hydatid cysts (in vitro study). World J Gastroenterol. 2009 Jan 7;15(1):112-6.

Density	1.42g/cm3
Melting Point	290-292ºC
Molecular Formula	C₁₂H₁₅N₃O₄S
Molecular Weight	297.33000
Exact Mass	297.07800
PSA	109.53000
LogP	3.07870
Index of Refraction	1.619
Storage condition	-20°C Freezer
Water Solubility	Soluble in DMSO, and methanol.

Albendazole sulfone MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DD6520700

CHEMICAL NAME :: 2-Benzimidazolecarbamic acid, 5-(propylsulfonyl)-, methyl ester

CAS REGISTRY NUMBER :: 75184-71-3

LAST UPDATED :: 198910

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C12-H15-N3-O4-S

MOLECULAR WEIGHT :: 297.36

WISWESSER LINE NOTATION :: T56 BM DNJ CMVO1 GSW3

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 75 mg/kg

SEX/DURATION :: female 8-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Effects on Embryo or Fetus - fetal death Reproductive - Specific Developmental Abnormalities - musculoskeletal system

REFERENCE :: ARCVBP Annales Recherches Veterinaires. (Institut National de la Recherche Agronomique, Service des Publ., Route de Saint-Cyr, 78000 Versailles, France) V.1- 1970- Volume(issue)/page/year: 12,159,1981

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 75 mg/kg

SEX/DURATION :: female 8-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - other developmental abnormalities

REFERENCE :: ARCVBP Annales Recherches Veterinaires. (Institut National de la Recherche Agronomique, Service des Publ., Route de Saint-Cyr, 78000 Versailles, France) V.1- 1970- Volume(issue)/page/year: 12,159,1981

Symbol	GHS07, GHS08
Signal Word	Warning
Hazard Statements	H315-H319-H361d
Precautionary Statements	P281-P305 + P351 + P338
Hazard Codes	Xn
Risk Phrases	63-36/38
Safety Phrases	26-36/37
RIDADR	NONH for all modes of transport
RTECS	DD6520700
HS Code	29339900

Development and validation of an ultra high performance liquid chromatography tandem mass spectrometry method for simultaneous determination of sulfonamides, quinolones and benzimidazoles in bovine milk.

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 962 , 20-9, (2014)

A simple, sensitive and reliable analytical method was developed for the simultaneous determination of 38 veterinary drugs (18 sulfonamides, 11 quinolones and 9 benzimidazoles) and 8 metabolites of be...

Nickel Oxide Nanoparticle-Deposited Silica Composite Solid-Phase Extraction for Benzimidazole Residue Analysis in Milk and Eggs by Liquid Chromatography-Mass Spectrometry.

J. Agric. Food Chem. 64 , 356-63, (2016)

A novel nickel oxide nanoparticle-deposited silica (SiO2@NiO) composite was prepared via liquid-phase deposition (LPD) and then employed as a solid-phase extraction (SPE) sorbent. When the SPE was cou...

albendazole sulfone