Albendazole sulfone

Modify Date: 2024-01-14 14:08:17

Albendazole sulfone Structure
Albendazole sulfone structure
Common Name Albendazole sulfone
CAS Number 75184-71-3 Molecular Weight 297.33000
Density 1.42g/cm3 Boiling Point N/A
Molecular Formula C12H15N3O4S Melting Point 290-292ºC
MSDS Chinese USA Flash Point N/A
Symbol GHS07 GHS08
GHS07, GHS08
Signal Word Warning

 Use of Albendazole sulfone


Albendazole sulfone is a metabolite of Albendazole, and exhibits anti-parasite effect against Echinococcus multilocularis Metacestodes[1][2].

 Names

Name Albendazole sulfone
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.42g/cm3
Melting Point 290-292ºC
Molecular Formula C12H15N3O4S
Molecular Weight 297.33000
Exact Mass 297.07800
PSA 109.53000
LogP 3.07870
Index of Refraction 1.619
Storage condition -20°C Freezer
Water Solubility Soluble in DMSO, and methanol.

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DD6520700
CHEMICAL NAME :
2-Benzimidazolecarbamic acid, 5-(propylsulfonyl)-, methyl ester
CAS REGISTRY NUMBER :
75184-71-3
LAST UPDATED :
198910
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C12-H15-N3-O4-S
MOLECULAR WEIGHT :
297.36
WISWESSER LINE NOTATION :
T56 BM DNJ CMVO1 GSW3

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
75 mg/kg
SEX/DURATION :
female 8-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Effects on Embryo or Fetus - fetal death Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
ARCVBP Annales Recherches Veterinaires. (Institut National de la Recherche Agronomique, Service des Publ., Route de Saint-Cyr, 78000 Versailles, France) V.1- 1970- Volume(issue)/page/year: 12,159,1981
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
75 mg/kg
SEX/DURATION :
female 8-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - other developmental abnormalities
REFERENCE :
ARCVBP Annales Recherches Veterinaires. (Institut National de la Recherche Agronomique, Service des Publ., Route de Saint-Cyr, 78000 Versailles, France) V.1- 1970- Volume(issue)/page/year: 12,159,1981

 Safety Information

Symbol GHS07 GHS08
GHS07, GHS08
Signal Word Warning
Hazard Statements H315-H319-H361d
Precautionary Statements P281-P305 + P351 + P338
Hazard Codes Xn
Risk Phrases 63-36/38
Safety Phrases 26-36/37
RIDADR NONH for all modes of transport
RTECS DD6520700
HS Code 29339900

 Articles2

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J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 962 , 20-9, (2014)

A simple, sensitive and reliable analytical method was developed for the simultaneous determination of 38 veterinary drugs (18 sulfonamides, 11 quinolones and 9 benzimidazoles) and 8 metabolites of be...

Nickel Oxide Nanoparticle-Deposited Silica Composite Solid-Phase Extraction for Benzimidazole Residue Analysis in Milk and Eggs by Liquid Chromatography-Mass Spectrometry.

J. Agric. Food Chem. 64 , 356-63, (2016)

A novel nickel oxide nanoparticle-deposited silica (SiO2@NiO) composite was prepared via liquid-phase deposition (LPD) and then employed as a solid-phase extraction (SPE) sorbent. When the SPE was cou...

 Synonyms

albendazole sulfone