Oncrasin-1
Modify Date: 2024-01-05 12:34:59
Oncrasin-1 structure
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Common Name | Oncrasin-1 | ||
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| CAS Number | 75629-57-1 | Molecular Weight | 269.72600 | |
| Density | 1.21g/cm3 | Boiling Point | 465.5ºC at 760 mmHg | |
| Molecular Formula | C16H12ClNO | Melting Point | 117 °C | |
| MSDS | USA | Flash Point | 235.3ºC | |
Use of Oncrasin-1Oncrasin-1 is a potent and effective anticancer inhibitor that kills various human lung cancer cells with K-Ras mutations at low or submicromolar concentrations; also led to abnormal aggregationof PKCι in nucleus of sensitive cells but not in resistant cells.IC50 value: 1.0 μM(A549, K-ras 12H and p53 Wt) [1]Target: human lung cancer cells with K-Ras mutation; K-Ras/PKCiota pathway inhibitorin vitro: effectively kills various human lung cancer cells with K-Ras mutations at low or submicromolar concentrations. The cytotoxic effects correlated with apoptosis inductionas was evidenced by increase of apoptotic cells and activation of caspase-3 and caspase-8 upon the treatment of oncrasin-1 in sensitive cells.Treatment with oncrasin-1 also led to abnormal aggregationof PKCι in nucleus of sensitive cells but not in resistant cells. Furthermore, oncrasin-1 induced apoptosis was blocked by siRNA of K-Ras or PKCι suggesting that oncrasin-1 is targeted to a novel K-Ras/PKCι pathway [1]. oncrasin-1 treatment led to coaggregation of PKCiota and splicing factors into megaspliceosomes but had no obvious effects on the DNA repair molecule Rad51. Moreover, oncrasin-1 treatment suppressed the phosphorylation of the largest subunit of RNA polymerase II and the expression of intronless reporter genes in sensitive cells but not in resistant cells [2]. in vivo: The in vivo administration of oncrasin-1 suppressed the growth of K-ras mutant human lung tumor xenografts by >70% and prolonged the survival of nude mice bearing these tumors, without causing detectable toxicity [1]. |
| Name | 1-[(4-chlorophenyl)methyl]indole-3-carbaldehyde |
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| Synonym | More Synonyms |
| Description | Oncrasin-1 is a potent and effective anticancer inhibitor that kills various human lung cancer cells with K-Ras mutations at low or submicromolar concentrations; also led to abnormal aggregationof PKCι in nucleus of sensitive cells but not in resistant cells.IC50 value: 1.0 μM(A549, K-ras 12H and p53 Wt) [1]Target: human lung cancer cells with K-Ras mutation; K-Ras/PKCiota pathway inhibitorin vitro: effectively kills various human lung cancer cells with K-Ras mutations at low or submicromolar concentrations. The cytotoxic effects correlated with apoptosis inductionas was evidenced by increase of apoptotic cells and activation of caspase-3 and caspase-8 upon the treatment of oncrasin-1 in sensitive cells.Treatment with oncrasin-1 also led to abnormal aggregationof PKCι in nucleus of sensitive cells but not in resistant cells. Furthermore, oncrasin-1 induced apoptosis was blocked by siRNA of K-Ras or PKCι suggesting that oncrasin-1 is targeted to a novel K-Ras/PKCι pathway [1]. oncrasin-1 treatment led to coaggregation of PKCiota and splicing factors into megaspliceosomes but had no obvious effects on the DNA repair molecule Rad51. Moreover, oncrasin-1 treatment suppressed the phosphorylation of the largest subunit of RNA polymerase II and the expression of intronless reporter genes in sensitive cells but not in resistant cells [2]. in vivo: The in vivo administration of oncrasin-1 suppressed the growth of K-ras mutant human lung tumor xenografts by >70% and prolonged the survival of nude mice bearing these tumors, without causing detectable toxicity [1]. |
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| Related Catalog | |
| References |
| Density | 1.21g/cm3 |
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| Boiling Point | 465.5ºC at 760 mmHg |
| Melting Point | 117 °C |
| Molecular Formula | C16H12ClNO |
| Molecular Weight | 269.72600 |
| Flash Point | 235.3ºC |
| Exact Mass | 269.06100 |
| PSA | 22.00000 |
| LogP | 4.15550 |
| Index of Refraction | 1.62 |
| Hazard Codes | Xi |
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| RIDADR | NONH for all modes of transport |
| HS Code | 2933990090 |
![3-[(1-pyrrolidinyl)methylene]-3H-indole structure](https://www.chemsrc.com/caspic/025/75629-45-7.png)
![1-[(4-CHLOROPHENYL)METHYL]-1H-INDOLE-3-METHANOL structure](https://www.chemsrc.com/caspic/179/92407-91-5.png)
CAS#:92407-91-5| HS Code | 2933990090 |
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| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
| Oncrasin 1 |
| 1-(4-Chlorobenzyl)-1H-indole-3-carbaldehyde |
| Oncrasin-1 |