Asiaol-Gm1-tetrasaccharide
Modify Date: 2024-01-03 12:13:46
Asiaol-Gm1-tetrasaccharide structure
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Common Name | Asiaol-Gm1-tetrasaccharide | ||
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| CAS Number | 75645-24-8 | Molecular Weight | 707.63000 | |
| Density | 1.72g/cm3 | Boiling Point | 1173.6ºC at 760 mmHg | |
| Molecular Formula | C26H45NO21 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 663.6ºC | |
Use of Asiaol-Gm1-tetrasaccharideGangliotetraose (Gg4) is a tetrasccharide, exhibits major components including GM1 and its sialylated derivatives. GM1 facilitates efflux of nuclear Ca2+ and reduces the level of nuclear Ca2+ that characterizes the differentiated neuron. GM1 affects neuronal plasticity and repair mechanisms, as well as neurotrophin release in the brain[1][2]. |
| Name | Gangliotetraose |
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| Description | Gangliotetraose (Gg4) is a tetrasccharide, exhibits major components including GM1 and its sialylated derivatives. GM1 facilitates efflux of nuclear Ca2+ and reduces the level of nuclear Ca2+ that characterizes the differentiated neuron. GM1 affects neuronal plasticity and repair mechanisms, as well as neurotrophin release in the brain[1][2]. |
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| Related Catalog | |
| Target |
Akt, ERK1/2[3]; amyloid β-protein[4] |
| In Vitro | Gangliotetraose (GM1) (10 μM; 1 h) increases the viability of pheochromocytoma PC12 cells exposed to hydrogen peroxide (1 mM; 2 h) and diminishes the accumulation of reactive oxygen species and oxidative inactivation of Na+, K+-ATPase[3]. Gangliotetraose (GM1) (100 nM and 10 μM; ) increases the basal activity of Akt and ERK1/2, without changing Akt activity in PC12 cells exposed to hydrogen peroxide[3]. Gangliotetraose (GM1) (50 μM; 24 h) binds the midportion of Aβ to produce Aβ oligomers, GM1 bound Aβ (GAβ). GAβ is endogenously generated in the brain and accelerates Aβ assembly by acting as a seed[4]. Cell Viability Assay[3] Cell Line: Rat pheochromocytoma PC12 cells Concentration: 1 nM, 10 nM, 100 nM, 1 μM, 10 μM, 50 μM Incubation Time: 1 hour (preincubation); started 24 h after the transfer of the cells to the plates; exposed to 1 mM H2O2 for 2 h later Result: Showed protective effect (rescue rates, %) on PC12 cells exposed to H2O2 in a dose-dependent manner. The rescue rates ranged from 2.7% to 76% with concentration of 1 nM-50 μM. |
| In Vivo | Gangliotetraose (GM1) (30 mg/kg; i.p.; 5, 11, 42, and 73 d) stimulates the regeneration of nigrostriatal dopaminergic neurons in the central nervous system of rats after unilateral hemitransection[5]. Animal Model: Unilateral semi-transection model in Sprague-Dawley rats (170-190 g)[5] Dosage: 5 mg/kg; 30 mg/kg Administration: Intraperitoneal injection; 5, 11, 42, 73 days; started on day 2 after surgery and finished 24 h before sacrifice Result: Increased the Vmax of tyrosine hydroxylase (TH) in the lesioned side starting on day 14 dose-dependently with 73% (5 mg/kg/d) and 85% (30 mg/kg/d) of that of the unlesioned side, respectively. |
| References |
| Density | 1.72g/cm3 |
|---|---|
| Boiling Point | 1173.6ºC at 760 mmHg |
| Molecular Formula | C26H45NO21 |
| Molecular Weight | 707.63000 |
| Flash Point | 663.6ºC |
| Exact Mass | 707.24800 |
| PSA | 356.70000 |
| Index of Refraction | 1.652 |