KP136
KP136 structure
|
Common Name | KP136 | ||
|---|---|---|---|---|
| CAS Number | 76239-32-2 | Molecular Weight | 314.33900 | |
| Density | 1.289g/cm3 | Boiling Point | 556.9ºC at 760 mmHg | |
| Molecular Formula | C16H18N4O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 290.6ºC | |
Use of KP136KP136 is an orally effective antiallergic agent. The IC50 is 76.1 μg/mL for histamine release and 63 ug/mL for degranulation. |
Summary: KP136, also known as 8-hexoxy-3-(2H-tetrazol-5-yl)chromen-2-one, has a CAS number of 76239-32-2, with a molecular formula of C16H18N4O3 and a molecular weight of 314.33900. It is an orally effective antihistamine, inhibiting histamine release and cell degranulation with IC50 values of 76.1 μg/mL and 63 μg/mL respectively. For research-use only, not for medical or clinical usage.
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | 8-hexoxy-3-(2H-tetrazol-5-yl)chromen-2-one |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | KP136 is an orally effective antiallergic agent. The IC50 is 76.1 μg/mL for histamine release and 63 ug/mL for degranulation. |
|---|---|
| Related Catalog | |
| Target |
Histamine release[1] |
| In Vitro | KP136 (0.01 μg/mL) inhibits this histamine release and degranulation in a dose-dependent manner, confirming that it is an inhibitor of mast cell activation. The IC50 is 76.1 μg/mL for histamine release and 63 ug/mL for degranulation[1]. |
| In Vivo | C4C at 0.2 mg/kg produces an equipotent effect to 1 mg/kg KP136 (KP-136) or 5 mg/kg DSCG. However, C4C is less effective by the oral route because it only produces a maximum inhibition of about 35% even at the high dose of 100 mg/kg, whereas KP136 shows an overt inhibitory effect of about 66% at the oral dose of 2 mg/kg. On the other hand, KP136 (1 mg/kg, i.v.) also remarkably inhibits 5-h homologous PCA, having an activity similar to that of C4C[1]. |
| Kinase Assay | The sensitized peritoneal exudate cells are taken from rats weighing 140-180 g with a 24-hr latent period, into which anti-DNP-As serum (0.1 mL) is injected in traperitoneally and suspended at a density of 5×104 mast cells/mL in PBS, pH 7.2 [137 mM NaCl, 2.7 mM KCl, 1 mM CaCl2, 1 mM MgCl2 6H20, 5.6 mM glucose and 5% (v/v) of 0.1 M phosphate buffer]. For histamine release assay, 2.5 mL of the cell suspension are mixed with 0.5 mL of PBS containing a test compound and DNP-As. The mixture is incubated at 37°C for 10 min and centrifuged at 670× g for 10 min. The histamine contents of the precipitate and the supernatant are measured by the fluorometric method. The mast cell degranulaton assay is carried out. The sensitized cell suspension (50 μL) is mixed with 50 μL of PBS containing a test compound and DNP-As in a Bellco micro-slide culture chamber. The chamber is incubated at 37°C for 10 min, and the cells on microscope slides are fixed and stained by the addition (100 μL/chamber) of 20% neutral formalin solution containing 0.2% toluidine blue. The proportion of mast cells undergoing degranulation is assessed for about 200 mast cells under microscopic observation[1]. |
| Animal Admin | Pigs[1] The trachea is taken from male guinea pigs, weighing 500-590 g, that are sacrificed by bleeding and then cut into 1.5 mm wide to make tracheal rings. Five specimens are tied at cartilage sites crossing each smooth muscle layer. This preparation is incubated in Tyrode's solution at 37°C, which is bubbled with 95% O2/5% CO2. The tension change of the tracheal muscle preparation is recorded through an isotonic transducer. C4C and KP136 in 0.5% KHCO3 or isoproterenol in saline is added cumulatively to the Tyrode's solution at a 1/200 volume. Relaxation percentage is calculated from the maximum relaxation value (100%) produces by re placement of the bathing medium with Tyrode's solution containing no CaCl2. |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 1.289g/cm3 |
|---|---|
| Boiling Point | 556.9ºC at 760 mmHg |
| Molecular Formula | C16H18N4O3 |
| Molecular Weight | 314.33900 |
| Flash Point | 290.6ºC |
| Exact Mass | 314.13800 |
| PSA | 93.90000 |
| LogP | 2.93220 |
| Index of Refraction | 1.594 |
| InChIKey | GUIWTWATPUPDDY-UHFFFAOYSA-N |
| SMILES | CCCCCCOc1cccc2cc(-c3nn[nH]n3)c(=O)oc12 |
| Storage condition | 2-8℃ |
This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| 8-(Hexyloxy)-3-(1H-tetrazol-5-yl)-2H-1-benzopyran-2-one |
| 2H-1-Benzopyran-2-one,8-(hexyloxy)-3-(1H-tetrazol-5-yl) |
| AL 136 |
| 8-n-Hexyloxy-3-(1H-tetrazol-5-yl)coumarin |
| KP 136 |
| KP136 |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What are the uses of 8-hexoxy-3-(2H-tetrazol-5-yl)chromen-2-one? |
| A: Main uses of 8-hexoxy-3-(2H-tetrazol-5-yl)chromen-2-one: KP136 is an orally effective antiallergic agent. The IC50 is 76.1 μg/mL for histamine release and 63 ug/mL for degranulation. |
| Q: What is the SMILES notation of 8-hexoxy-3-(2H-tetrazol-5-yl)chromen-2-one? |
| A: SMILES notation of 8-hexoxy-3-(2H-tetrazol-5-yl)chromen-2-one is CCCCCCOc1cccc2cc(-c3nn[nH]n3)c(=O)oc12. |
| Q: What is the English name of 8-hexoxy-3-(2H-tetrazol-5-yl)chromen-2-one? |
| A: The English name of 8-hexoxy-3-(2H-tetrazol-5-yl)chromen-2-one is 8-hexoxy-3-(2H-tetrazol-5-yl)chromen-2-one. |
| Q: What is the Chinese name of 76239-32-2? |
| A: Chinese name of 76239-32-2 is KP136. |
| Q: What is the molecular formula of 8-hexoxy-3-(2H-tetrazol-5-yl)chromen-2-one? |
| A: Molecular formula of 8-hexoxy-3-(2H-tetrazol-5-yl)chromen-2-one is C16H18N4O3. |
| Q: What is the molecular weight of 8-hexoxy-3-(2H-tetrazol-5-yl)chromen-2-one? |
| A: Molecular weight of 8-hexoxy-3-(2H-tetrazol-5-yl)chromen-2-one is 314.33900. |
| Q: What are the storage conditions for 8-hexoxy-3-(2H-tetrazol-5-yl)chromen-2-one? |
| A: Storage conditions for 8-hexoxy-3-(2H-tetrazol-5-yl)chromen-2-one: 2-8℃. |
| Q: What English synonyms does 8-hexoxy-3-(2H-tetrazol-5-yl)chromen-2-one have? |
| A: English synonyms of 8-hexoxy-3-(2H-tetrazol-5-yl)chromen-2-one: 8-(Hexyloxy)-3-(1H-tetrazol-5-yl)-2H-1-benzopyran-2-one, 2H-1-Benzopyran-2-one,8-(hexyloxy)-3-(1H-tetrazol-5-yl), AL 136, 8-n-Hexyloxy-3-(1H-tetrazol-5-yl)coumarin, KP 136, KP136. |
| Q: What is the boiling point of 8-hexoxy-3-(2H-tetrazol-5-yl)chromen-2-one? |
| A: Boiling point of 8-hexoxy-3-(2H-tetrazol-5-yl)chromen-2-one is 556.9ºC at 760 mmHg. |
| Q: What is the CAS number of 8-hexoxy-3-(2H-tetrazol-5-yl)chromen-2-one? |
| A: CAS number of 8-hexoxy-3-(2H-tetrazol-5-yl)chromen-2-one is 76239-32-2. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |