2-methylbenzohydrazide

Modify Date: 2026-06-30 10:51:45

2-methylbenzohydrazide Structure
2-methylbenzohydrazide structure
Common Name 2-methylbenzohydrazide
CAS Number 7658-80-2 Molecular Weight 150.18
Density 1.3±0.1 g/cm3 Boiling Point 448.5±45.0 °C at 760 mmHg
Molecular Formula C8H10N2O Melting Point 121-125 °C
MSDS N/A Flash Point 225.1±28.7 °C

 Names

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name 2-Methylbenzohydrazide
Synonym More Synonyms

 Chemical & Physical Properties

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Density 1.3±0.1 g/cm3
Boiling Point 448.5±45.0 °C at 760 mmHg
Melting Point 121-125 °C
Molecular Formula C8H10N2O
Molecular Weight 150.18
Flash Point 225.1±28.7 °C
Exact Mass 150.079312947
PSA 55.12000
LogP 2.42
Vapour Pressure 0.0±1.1 mmHg at 25°C
Index of Refraction 1.626
InChIKey KFXLXEQCRFGDRU-UHFFFAOYSA-N
SMILES CC1=CC=CC=C1C(=O)NN
Storage condition 2-8°C

 MSDS

This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.

Name: o-Toluic hydrazide Material Safety Data Sheet
Synonym:
CAS: 7658-80-2
Section 1 - Chemical Product MSDS Name:o-Toluic hydrazide Material Safety Data Sheet
Synonym:

Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
CAS# Chemical Name content EINECS#
7658-80-2 o-Toluic hydrazide 231-623-8
Hazard Symbols: XI
Risk Phrases: 36/37/38

Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Irritating to eyes, respiratory system and skin.
Potential Health Effects
Eye:
Causes eye irritation.
Skin:
Causes skin irritation. May be harmful if absorbed through the skin.
Ingestion:
May cause irritation of the digestive tract. May be harmful if swallowed.
Inhalation:
Causes respiratory tract irritation. May be harmful if inhaled.
Chronic:
Not available.

Section 4 - FIRST AID MEASURES
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Ingestion:
Get medical aid. Wash mouth out with water.
Inhalation:
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:
Treat symptomatically and supportively.

Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear.
Extinguishing Media:
Use water spray, dry chemical, carbon dioxide, or chemical foam.

Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal container. Avoid generating dusty conditions.

Section 7 - HANDLING and STORAGE
Handling:
Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes.
Storage:
Store in a cool, dry place. Store in a tightly closed container.

Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 7658-80-2: Personal Protective Equipment Eyes: Not available.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Solid
Color: Not available.
Odor: Not available.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: 122 - 124 deg C
Autoignition Temperature: Not available.
Flash Point: Not available.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water:
Specific Gravity/Density:
Molecular Formula: C8H10N2O
Molecular Weight: 150.18

Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Incompatible materials.
Incompatibilities with Other Materials:
Strong oxidizing agents.
Hazardous Decomposition Products:
Nitrogen oxides, carbon monoxide, carbon dioxide.
Hazardous Polymerization: Has not been reported

Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 7658-80-2 unlisted.
LD50/LC50:
Not available.
Carcinogenicity:
o-Toluic hydrazide - Not listed by ACGIH, IARC, or NTP.

Section 12 - ECOLOGICAL INFORMATION


Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

Section 14 - TRANSPORT INFORMATION

IATA
No information available.
IMO
No information available.
RID/ADR
No information available.

Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: XI
Risk Phrases:
R 36/37/38 Irritating to eyes, respiratory system
and skin.
Safety Phrases:
S 26 In case of contact with eyes, rinse immediately
with plenty of water and seek medical advice.
S 37/39 Wear suitable gloves and eye/face
protection.
WGK (Water Danger/Protection)
CAS# 7658-80-2: No information available.
Canada
None of the chemicals in this product are listed on the DSL/NDSL list.
CAS# 7658-80-2 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 7658-80-2 is not listed on the TSCA inventory.
It is for research and development use only.


SECTION 16 - ADDITIONAL INFORMATION
N/A

 Safety Information

This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.

Hazard Codes Xi:Irritant;
Risk Phrases R36/37/38
Safety Phrases S37/39-S26
HS Code 2928000090

 Synthetic Route

This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.

~94%

2-methylbenzohydrazide Structure

2-methylbenzohy...

CAS#:7658-80-2

Learn More
Literature: Macaev, Fliur; Rusu, Ghenadie; Pogrebnoi, Serghei; Gudima, Alexandru; Stingaci, Eugenia; Vlad, Ludmila; Shvets, Nathaly; Kandemirli, Fatma; Dimoglo, Anatholy; Reynolds, Robert Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 16 p. 4842 - 4850

~%

2-methylbenzohydrazide Structure

2-methylbenzohy...

CAS#:7658-80-2

Learn More
Literature: Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 349 - 355

~83%

2-methylbenzohydrazide Structure

2-methylbenzohy...

CAS#:7658-80-2

Learn More
Literature: Saha, Ajoy; Kumar, Rajesh; Kumar, Rajendra; Devakumar Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2010 , vol. 49, # 4 p. 526 - 531

~%

2-methylbenzohydrazide Structure

2-methylbenzohy...

CAS#:7658-80-2

Learn More
Literature: Journal of Medicinal Chemistry, , vol. 26, # 8 p. 1187 - 1192

 Customs

This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.

HS Code 2928000090
Summary 2928000090 other organic derivatives of hydrazine or of hydroxylamine VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%

 2-methylbenzohydrazideBioassay

View more

This table contains target information, in‑vitro & in‑vivo assay data for this compound.

Name: NCI human tumor cell line growth inhibition assay. Data for the MCF7 Non-Small Cell L...
Source: DTP/NCI
Target: N/A
External Id: MCF7_OneDose
Name: NCI human tumor cell line growth inhibition assay. Data for the IGROV1 Non-Small Cell...
Source: DTP/NCI
Target: N/A
External Id: IGROV1_OneDose
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 Synonyms

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

6-{(E)-[(4-Methylphenyl)imino]methyl}-1,3-benzodioxol-5-amine
2-methylbenzohydrazide
MFCD00014756
EINECS 231-623-8

 2-methylbenzohydrazide | FAQ

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What is the polar surface area (PSA) of 2-Methylbenzohydrazide?
A: Polar surface area (PSA) of 2-Methylbenzohydrazide is 55.12000.
Q: What is the LogP of 2-Methylbenzohydrazide?
A: LogP of 2-Methylbenzohydrazide is 2.42.
Q: What is the safety information for 2-Methylbenzohydrazide?
A: Safety information for 2-Methylbenzohydrazide: S37/39-S26.
Q: What is the CAS number of 2-Methylbenzohydrazide?
A: CAS number of 2-Methylbenzohydrazide is 7658-80-2.
Q: What English synonyms does 2-Methylbenzohydrazide have?
A: English synonyms of 2-Methylbenzohydrazide: 6-{(E)-[(4-Methylphenyl)imino]methyl}-1,3-benzodioxol-5-amine, 2-methylbenzohydrazide, MFCD00014756, EINECS 231-623-8.
Q: What is the InChIKey of 2-Methylbenzohydrazide?
A: InChIKey of 2-Methylbenzohydrazide is KFXLXEQCRFGDRU-UHFFFAOYSA-N.
Q: What is the SMILES notation of 2-Methylbenzohydrazide?
A: SMILES notation of 2-Methylbenzohydrazide is CC1=CC=CC=C1C(=O)NN.
Q: What is the melting point of 2-Methylbenzohydrazide?
A: Melting point of 2-Methylbenzohydrazide is 121-125 °C.
Q: What is the molecular weight of 2-Methylbenzohydrazide?
A: Molecular weight of 2-Methylbenzohydrazide is 150.18.
Q: What are the storage conditions for 2-Methylbenzohydrazide?
A: Storage conditions for 2-Methylbenzohydrazide: 2-8°C.

 2-methylbenzohydrazidefactory

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Shanghai Nianxing Industrial Co., Ltd
Dayang Chem (Hangzhou) Co., Ltd.
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