Tocopheryl acetate

Modify Date: 2024-01-02 12:06:39

Tocopheryl acetate Structure
Tocopheryl acetate structure
Common Name Tocopheryl acetate
CAS Number 7695-91-2 Molecular Weight 472.743
Density 0.9±0.1 g/cm3 Boiling Point 485.3±0.0 °C at 760 mmHg
Molecular Formula C31H52O3 Melting Point -28ºC
MSDS Chinese USA Flash Point 235.6±24.7 °C

 Use of Tocopheryl acetate


(±)-α-Tocopherol acetate ((±)-Vitamin E acetate), is a orally active synthetic form of vitamin E. (±)-α-Tocopherol acetate is the ester of acetic acid and α-tocopherol. (±)-α-Tocopherol acetate can be used for the research of the susceptibility of farmed fish to infectious diseases[1].

 Names

Name Vitamin E Acetate
Synonym More Synonyms

 Tocopheryl acetate Biological Activity

Description (±)-α-Tocopherol acetate ((±)-Vitamin E acetate), is a orally active synthetic form of vitamin E. (±)-α-Tocopherol acetate is the ester of acetic acid and α-tocopherol. (±)-α-Tocopherol acetate can be used for the research of the susceptibility of farmed fish to infectious diseases[1].
Related Catalog
In Vivo (±)-α-Tocopherol acetate ((±)-Vitamin E acetate) (oral; 600 mg/kg, 1200 mg/kg, 1800 mg/kg; 15 d, 30 d and 45 d) exhibits significantly high complement activity[1]. (±)-α-Tocopherol acetate (oral; 600 mg/kg, 1200 mg/kg, 1800 mg/kg; 15 d, 30 d and 45 d) stimulates the seabream's non-specific immune system after 30 days of administration in the diet (1200 mg/kg)[1]. Animal Model: Gilthead seabream (Sparus aurata L.)[1] Dosage: 600 mg/kg, 1200 mg/kg, 1800 mg/kg Administration: oral; 600 mg/kg, 1200 mg/kg, 1800 mg/kg; 15 d,30 d and 45 d Result: Had a positive correlation with serum α-tocopherol levels and the increase being linked to both the dosage and length of use. Showed no enhancement in any of their immune parameters, while those fed the diet supplemented with 1200 mg/kg presented a slightly higher (but not statistically significant) specific growth rate than fish fed the other diets. Enhanced the serum haemolytic activity and the phagocytosis of head-kidney leucocytes by the dietary intake of 1200 mg/kg after 30 and 45 days, although leucocyte migration and respiratory burst activity remained unaffected. Provoked no immunostimulation in 1800 mg/kg.
References

[1]. J Ortuño, et al. High dietary intake of alpha-tocopherol acetate enhances the non-specific immune response of gilthead seabream (Sparus aurata L.). Fish Shellfish Immunol. 2000 May;10(4):293-307

 Chemical & Physical Properties

Density 0.9±0.1 g/cm3
Boiling Point 485.3±0.0 °C at 760 mmHg
Melting Point -28ºC
Molecular Formula C31H52O3
Molecular Weight 472.743
Flash Point 235.6±24.7 °C
Exact Mass 472.391632
PSA 35.53000
LogP 12.07
Vapour Pressure 0.0±1.2 mmHg at 25°C
Index of Refraction 1.488
Storage condition 2-8°C

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
GA8747000
CHEMICAL NAME :
6-Chromanol, 2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-, acetate
CAS REGISTRY NUMBER :
7695-91-2
BEILSTEIN REFERENCE NO. :
0097512
LAST UPDATED :
199707
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C31-H52-O3
MOLECULAR WEIGHT :
472.83
WISWESSER LINE NOTATION :
T66 BOT&J C3Y1&3Y1&3Y1&1 C1 G1 HOV1 I1 J1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
500 mg/kg
SEX/DURATION :
female 1-22 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

MUTATION DATA

TEST SYSTEM :
Rodent - rat
DOSE/DURATION :
2500 ug/kg
REFERENCE :
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975- Volume(issue)/page/year: 25,163,1984

 Safety Information

Personal Protective Equipment Eyeshields;Gloves
Safety Phrases S24/25
RIDADR NONH for all modes of transport
WGK Germany 1
RTECS GA8747000
HS Code 29362800

 Customs

HS Code 29362800

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 Synonyms

(2R)-2,5,7,8-Tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydro-2H-chromen-6-yl acetate
a-Tocopheryl Acetate
Vitamin E acetate
[2R*(4R*,8R*)]-3,4-Dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-ol Acetate
EINECS 231-710-0
Eprolin
Tocopheryl acetate
E-Vimin
Evion
MFCD00072042
2H-1-Benzopyran-6-ol, 3,4-dihydro-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-, acetate, (2R)-
Vitamin- E acetate
D-α-Tocopheryl acetate
a-Tocopherol Acetate
TOCOPHEROL ACETATE
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