LU-32-176B

Modify Date: 2024-01-09 18:52:33

LU-32-176B Structure
LU-32-176B structure
 Common Name LU-32-176B
CAS Number 770688-66-9 Molecular Weight 398.45
Density N/A Boiling Point N/A
Molecular Formula C23H24F2N2O2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of LU-32-176B


LU-32-176B, a GABA transporter 1(GAT1) selective inhibitor, is found to exert a synergistic anticonvulsant action with GAT2 transport inhibitor EF1502. LU-32-176B inhibits neurons, astrocytes and mGAT1 with the IC50 values of 2μM, 1μM, 4μM, respectively[1][2].

 Names

Name LU-32-176B

 LU-32-176B Biological Activity

Description LU-32-176B, a GABA transporter 1(GAT1) selective inhibitor, is found to exert a synergistic anticonvulsant action with GAT2 transport inhibitor EF1502. LU-32-176B inhibits neurons, astrocytes and mGAT1 with the IC50 values of 2μM, 1μM, 4μM, respectively[1][2].
Related Catalog
Target

LU-32-176B inhibits neurons, astrocytes and mGAT1 with the IC50 values of 2μM, 1μM, 4μM, respectively[1][2].

In Vivo LU-32-176B (i.p.) and EF1502 can prevent sound-induced seizures in the Frings AGS-susceptible mouse model[1].
References

[1]. Schousboe A, et al. GABA transporters as drug targets for modulation of GABAergic activity. Biochem Pharmacol. 2004;68(8):1557-1563.

[2]. White HS, et al. First demonstration of a functional role for central nervous system betaine/{gamma}-aminobutyric acid transporter (mGAT2) based on synergistic anticonvulsant action among inhibitors of mGAT1 and mGAT2. J Pharmacol Exp Ther. 2005;312(2):866-874.

 Chemical & Physical Properties

Molecular Formula C23H24F2N2O2
Molecular Weight 398.45

 Safety Information

Hazard Codes Xi
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Chemsrc provides LU-32-176B(CAS#:770688-66-9) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of LU-32-176B are included as well.>> amp version: LU-32-176B

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