770688-66-9

770688-66-9 structure

Name: LU-32-176B
Chemical Name: LU-32-176B
CAS Number: 770688-66-9
Molecular Formula: C₂₃H₂₄F₂N₂O₂
Molecular Weight: 398.45
Catalog: Signaling Pathways Membrane Transporter/Ion Channel GABA Receptor
Create Date: 2021-11-01 17:17:34
Modify Date: 2024-01-09 18:52:33
LU-32-176B, a GABA transporter 1(GAT1) selective inhibitor, is found to exert a synergistic anticonvulsant action with GAT2 transport inhibitor EF1502. LU-32-176B inhibits neurons, astrocytes and mGAT1 with the IC50 values of 2μM, 1μM, 4μM, respectively[1][2].

Name	LU-32-176B

Description	LU-32-176B, a GABA transporter 1(GAT1) selective inhibitor, is found to exert a synergistic anticonvulsant action with GAT2 transport inhibitor EF1502. LU-32-176B inhibits neurons, astrocytes and mGAT1 with the IC50 values of 2μM, 1μM, 4μM, respectively[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor Signaling Pathways >> Neuronal Signaling >> GABA Receptor
Target	LU-32-176B inhibits neurons, astrocytes and mGAT1 with the IC50 values of 2μM, 1μM, 4μM, respectively[1][2].
In Vivo	LU-32-176B (i.p.) and EF1502 can prevent sound-induced seizures in the Frings AGS-susceptible mouse model[1].
References	[1]. Schousboe A, et al. GABA transporters as drug targets for modulation of GABAergic activity. Biochem Pharmacol. 2004;68(8):1557-1563. [2]. White HS, et al. First demonstration of a functional role for central nervous system betaine/{gamma}-aminobutyric acid transporter (mGAT2) based on synergistic anticonvulsant action among inhibitors of mGAT1 and mGAT2. J Pharmacol Exp Ther. 2005;312(2):866-874.

Molecular Formula	C₂₃H₂₄F₂N₂O₂
Molecular Weight	398.45

Hazard Codes	Xi