3,5-Dichloro-4-fluorobenzotrifluoride structure
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Common Name | 3,5-Dichloro-4-fluorobenzotrifluoride | ||
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CAS Number | 77227-81-7 | Molecular Weight | 232.990 | |
Density | 1.5±0.1 g/cm3 | Boiling Point | 166.0±35.0 °C at 760 mmHg | |
Molecular Formula | C7H2Cl2F4 | Melting Point | N/A | |
MSDS | Chinese USA | Flash Point | 63.5±19.4 °C | |
Symbol |
GHS05, GHS06 |
Signal Word | Danger |
Name | 3,5-Dichloro-4-Fluorobenzotrifluoride |
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Synonym | More Synonyms |
Density | 1.5±0.1 g/cm3 |
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Boiling Point | 166.0±35.0 °C at 760 mmHg |
Molecular Formula | C7H2Cl2F4 |
Molecular Weight | 232.990 |
Flash Point | 63.5±19.4 °C |
Exact Mass | 231.946960 |
LogP | 4.76 |
Vapour Pressure | 2.4±0.3 mmHg at 25°C |
Index of Refraction | 1.455 |
Synonym:1,3-Dichloro-2-fluoro-5-(trifluoromethyl)-benzene; 3,5-Dichloro-4-fluoro-alpha,alpha,alpha-trifluorotoluen Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
Risk Phrases: 36/37/38 Section 3 - HAZARDS IDENTIFICATION EMERGENCY OVERVIEW
Irritating to eyes, respiratory system and skin. Potential Health Effects Eye: Causes eye irritation. Skin: Causes skin irritation. Ingestion: May cause gastrointestinal irritation with nausea, vomiting and diarrhea. Inhalation: Causes respiratory tract irritation. Chronic: No information found. Section 4 - FIRST AID MEASURES Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid. Skin: Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. Ingestion: Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water. Inhalation: Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. Notes to Physician: Treat symptomatically and supportively. Antidote: None reported. Section 5 - FIRE FIGHTING MEASURES General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use water spray to keep fire-exposed containers cool. Combustible liquid. Vapors may be heavier than air. They can spread along the ground and collect in low or confined areas. Containers may explode when heated. Extinguishing Media: In case of fire, use water, dry chemical, chemical foam, or alcohol-resistant foam. Use water spray to cool fire-exposed containers. Use water spray, dry chemical, carbon dioxide, or appropriate foam. Section 6 - ACCIDENTAL RELEASE MEASURES General Information: Use proper personal protective equipment as indicated in Section 8. Spills/Leaks: Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Clean up spills immediately, observing precautions in the Protective Equipment section. Remove all sources of ignition. Use a spark-proof tool. Provide ventilation. Section 7 - HANDLING and STORAGE Handling: Wash thoroughly after handling. Avoid contact with eyes, skin, and clothing. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Keep container tightly closed. Keep away from heat, sparks and flame. Avoid ingestion and inhalation. Use with adequate ventilation. Wash clothing before reuse. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames. Storage: Keep away from heat, sparks, and flame. Keep away from sources of ignition. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION Engineering Controls: Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low. Exposure Limits CAS# 77227-81-7: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure. Respirators: A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant respirator use. Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced. Section 9 - PHYSICAL AND CHEMICAL PROPERTIES Physical State: Liquid Color: colorless Odor: Not available. pH: Not available. Vapor Pressure: Not available. Viscosity: Not available. Boiling Point: 166 - 168 deg C Freezing/Melting Point: Not available. Autoignition Temperature: Not available. Flash Point: 73 deg C ( 163.40 deg F) Explosion Limits, lower: Not available. Explosion Limits, upper: Not available. Decomposition Temperature: Solubility in water: Specific Gravity/Density: 1.5550g/cm3 Molecular Formula: C7H2Cl2F4 Molecular Weight: 232.99 Section 10 - STABILITY AND REACTIVITY Chemical Stability: Stable at room temperature in closed containers under normal storage and handling conditions. Conditions to Avoid: Incompatible materials, ignition sources, excess heat. Incompatibilities with Other Materials: Strong oxidizing agents. Hazardous Decomposition Products: Carbon monoxide, irritating and toxic fumes and gases, carbon dioxide. Hazardous Polymerization: Has not been reported Section 11 - TOXICOLOGICAL INFORMATION RTECS#: CAS# 77227-81-7 unlisted. LD50/LC50: Not available. Carcinogenicity: 3,5-Dichloro-4-fluorobenzotrifluoride - Not listed by ACGIH, IARC, or NTP. Section 12 - ECOLOGICAL INFORMATION Section 13 - DISPOSAL CONSIDERATIONS Dispose of in a manner consistent with federal, state, and local regulations. Section 14 - TRANSPORT INFORMATION IATA Not regulated as a hazardous material. IMO Not regulated as a hazardous material. RID/ADR Not regulated as a hazardous material. Section 15 - REGULATORY INFORMATION European/International Regulations European Labeling in Accordance with EC Directives Hazard Symbols: XI Risk Phrases: R 36/37/38 Irritating to eyes, respiratory system and skin. Safety Phrases: S 26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S 37/39 Wear suitable gloves and eye/face protection. WGK (Water Danger/Protection) CAS# 77227-81-7: No information available. Canada None of the chemicals in this product are listed on the DSL/NDSL list. CAS# 77227-81-7 is not listed on Canada's Ingredient Disclosure List. US FEDERAL TSCA CAS# 77227-81-7 is not listed on the TSCA inventory. It is for research and development use only. SECTION 16 - ADDITIONAL INFORMATION N/A |
Symbol |
GHS05, GHS06 |
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Signal Word | Danger |
Hazard Statements | H301-H318 |
Precautionary Statements | P280-P301 + P310-P305 + P351 + P338 |
Personal Protective Equipment | Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter |
Hazard Codes | Xn:Harmful; |
Risk Phrases | R22;R41 |
Safety Phrases | S26-S36 |
RIDADR | UN 2810 6.1/PG 3 |
WGK Germany | 3 |
HS Code | 2903999090 |
~% 3,5-Dichloro-4-... CAS#:77227-81-7 |
Literature: WO2008/113660 A1, ; Page/Page column 11 ; |
~% 3,5-Dichloro-4-... CAS#:77227-81-7 |
Literature: US4388472 A1, ; |
HS Code | 2903999090 |
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Summary | 2903999090 halogenated derivatives of aromatic hydrocarbons VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0% |
Synthesis of a tritium-labeled, fipronil-based, highly potent, photoaffinity probe for the GABA receptor.
J. Org. Chem. 68(21) , 8075-9, (2003) 3-[4-[1-(2,6-dichloro-4-trifluoromethylphenyl)pyrazolo]]-3-(trifluoromethyl)diazirine is a fipronil-based (i.e. fiprole), high-affinity probe for the GABA receptor. For synthesis of the tritium-labele... |
1,3-Dichloro-2-fluoro-5-(trifluoromethyl)benzene |
Benzene, 1,3-dichloro-2-fluoro-5-(trifluoromethyl)- |
MFCD00068183 |
3,5-Dichloro-4-fluorobenzotrifluoride |