7-[(4-aminophenyl)methyl]pyrrolo[3,2-f]quinazoline-1,3-diamine

Modify Date: 2024-09-13 14:12:57

7-[(4-aminophenyl)methyl]pyrrolo[3,2-f]quinazoline-1,3-diamine structure	Common Name	7-[(4-aminophenyl)methyl]pyrrolo[3,2-f]quinazoline-1,3-diamine
	CAS Number	77681-42-6	Molecular Weight	340.81000
	Density	1.5g/cm3	Boiling Point	710.3ºC at 760 mmHg
	Molecular Formula	C₁₇H₁₇ClN₆	Melting Point	N/A
	MSDS	N/A	Flash Point	383.4ºC

Use of 7-[(4-aminophenyl)methyl]pyrrolo[3,2-f]quinazoline-1,3-diamine

NSC309401 is an inhibitor of E. coli DHFR (IC50: 189 nM, KD: 14.57 nM)[1].

Name	7-[(4-aminophenyl)methyl]pyrrolo[3,2-f]quinazoline-1,3-diamine

Description	NSC309401 is an inhibitor of E. coli DHFR (IC50: 189 nM, KD: 14.57 nM)[1].
Related Catalog	Research Areas >> Inflammation/Immunology Signaling Pathways >> Anti-infection >> Bacterial
Target	189 nM (E. coli DHFR)[1]
References	[1]. Srinivasan B, et al. Insights into the slow-onset tight-binding inhibition of Escherichia coli dihydrofolate reductase: detailed mechanistic characterization of pyrrolo [3,2-f] quinazoline-1,3-diamine and its derivatives as novel tight-binding inhibitors. FEBS J. 2015 May;282(10):1922-38.

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