Nepafenac
Nepafenac structure
|
Common Name | Nepafenac | ||
|---|---|---|---|---|
| CAS Number | 78281-72-8 | Molecular Weight | 254.284 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 562.5±50.0 °C at 760 mmHg | |
| Molecular Formula | C15H14N2O2 | Melting Point | 177-181ºC | |
| MSDS | USA | Flash Point | 294.0±30.1 °C | |
| Symbol |
GHS09 |
Signal Word | Warning | |
Use of NepafenacNepafenac(AHR 9434; AL 6515; Nevanac) is a selective COX-2 inhibitor; is prodrug of Amfenac.IC50 value:Target: COX-2Nepafenac is a NSAID (nonsteroidal anti inflammatory drug) that is routinely used in opthamology to control pain following cataract surgery. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | nepafenac |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | Nepafenac(AHR 9434; AL 6515; Nevanac) is a selective COX-2 inhibitor; is prodrug of Amfenac.IC50 value:Target: COX-2Nepafenac is a NSAID (nonsteroidal anti inflammatory drug) that is routinely used in opthamology to control pain following cataract surgery. |
|---|---|
| Related Catalog | |
| Target |
COX-1:64.3 μM (IC50) COX-2 |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 562.5±50.0 °C at 760 mmHg |
| Melting Point | 177-181ºC |
| Molecular Formula | C15H14N2O2 |
| Molecular Weight | 254.284 |
| Flash Point | 294.0±30.1 °C |
| Exact Mass | 254.105530 |
| PSA | 86.18000 |
| LogP | 0.73 |
| Vapour Pressure | 0.0±1.5 mmHg at 25°C |
| Index of Refraction | 1.641 |
| InChIKey | QEFAQIPZVLVERP-UHFFFAOYSA-N |
| SMILES | NC(=O)Cc1cccc(C(=O)c2ccccc2)c1N |
| Storage condition | Refrigerator |
This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.
This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| Symbol |
GHS09 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H400 |
| Precautionary Statements | P273 |
| Hazard Codes | N |
| Risk Phrases | 50/53 |
| Safety Phrases | 60-61 |
| RIDADR | UN 3077 9 / PGIII |
| HS Code | 2924299090 |
This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.
|
~84%
Nepafenac CAS#:78281-72-8 |
| Literature: Medichem, S.A. Patent: US2009/312575 A1, 2009 ; Location in patent: Page/Page column 5-6 ; |
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~%
Nepafenac CAS#:78281-72-8 |
| Literature: Journal of Medicinal Chemistry, , vol. 33, # 8 p. 2296 - 2304 |
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Nepafenac CAS#:78281-72-8 |
| Literature: US5475034 A1, ; |
This table lists upstream starting materials and downstream derivative products related to this chemical.
| Precursor 2 | |
|---|---|
| DownStream 0 | |
This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.
| HS Code | 2924299090 |
|---|---|
| Summary | 2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
This table lists relevant public references with title, journal and publication metadata for this compound.
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Use of nepafenac (Nevanac) in combination with intravitreal anti-VEGF agents in the treatment of recalcitrant exudative macular degeneration requiring monthly injections.
Clin. Ophthalmol. 4 , 1249-52, (2010) The purpose of this study is to determine the efficacy of combining topical nepafenac with monthly intravitreal injections of ranibizumab or bevacizumab in the treatment of recalcitrant exudative macu... |
This table contains target information, in‑vitro & in‑vivo assay data for this compound.
This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| Nevanac |
| 2-(2-Amino-3-benzoylphenyl)acetamide |
| Nepafenac |
| Nepafanac |
| 2-Amino-3-benzoylbenzeneacetamide |
| 2-[2-amino-3-(phénylcarbonyl)phényl]acétamide |
| AL 6515 |
| AHR 9434 |
| 2-[2-Amino-3-(phenylcarbonyl)phenyl]acetamid |
| 2-[2-amino-3-(phenylcarbonyl)phenyl]acetamide |
| 2-Amino-3-benzoyl-phenylacetamide |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What is the polar surface area (PSA) of nepafenac? |
| A: Polar surface area (PSA) of nepafenac is 86.18000. |
| Q: What is the LogP of nepafenac? |
| A: LogP of nepafenac is 0.73. |
| Q: What is the molecular weight of nepafenac? |
| A: Molecular weight of nepafenac is 254.284. |
| Q: What are the storage conditions for nepafenac? |
| A: Storage conditions for nepafenac: Refrigerator. |
| Q: What are the upstream materials of nepafenac? |
| A: Related upstream materials(CAS) of nepafenac: 78281-61-5;2835-77-0. |
| Q: What English synonyms does nepafenac have? |
| A: English synonyms of nepafenac: Nevanac, 2-(2-Amino-3-benzoylphenyl)acetamide, Nepafenac, Nepafanac, 2-Amino-3-benzoylbenzeneacetamide, 2-[2-amino-3-(phénylcarbonyl)phényl]acétamide, AL 6515, AHR 9434, 2-[2-Amino-3-(phenylcarbonyl)phenyl]acetamid, 2-[2-amino-3-(phenylcarbonyl)phenyl]acetamide, 2-Amino-3-benzoyl-phenylacetamide. |
| Q: What is the SMILES notation of nepafenac? |
| A: SMILES notation of nepafenac is NC(=O)Cc1cccc(C(=O)c2ccccc2)c1N. |
| Q: What are the uses of nepafenac? |
| A: Main uses of nepafenac: Nepafenac(AHR 9434; AL 6515; Nevanac) is a selective COX-2 inhibitor; is prodrug of Amfenac.IC50 value:Target: COX-2Nepafenac is a NSAID (nonsteroidal anti inflammatory drug) that is routinely used in opthamology to control pain following cataract surgery. |
| Q: What is the CAS number of nepafenac? |
| A: CAS number of nepafenac is 78281-72-8. |
| Q: What is the InChIKey of nepafenac? |
| A: InChIKey of nepafenac is QEFAQIPZVLVERP-UHFFFAOYSA-N. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| Henan Tianfu Chemical Co., Ltd. |