Nepafenac

Modify Date: 2024-01-08 20:08:58

Nepafenac structure	Common Name	Nepafenac
	CAS Number	78281-72-8	Molecular Weight	254.284
	Density	1.3±0.1 g/cm3	Boiling Point	562.5±50.0 °C at 760 mmHg
	Molecular Formula	C₁₅H₁₄N₂O₂	Melting Point	177-181ºC
	MSDS	USA	Flash Point	294.0±30.1 °C
	Symbol	GHS09	Signal Word	Warning

Use of Nepafenac

Nepafenac(AHR 9434; AL 6515; Nevanac) is a selective COX-2 inhibitor; is prodrug of Amfenac.IC50 value:Target: COX-2Nepafenac is a NSAID (nonsteroidal anti inflammatory drug) that is routinely used in opthamology to control pain following cataract surgery.

Name	nepafenac
Synonym	More Synonyms

Description	Nepafenac(AHR 9434; AL 6515; Nevanac) is a selective COX-2 inhibitor; is prodrug of Amfenac.IC50 value:Target: COX-2Nepafenac is a NSAID (nonsteroidal anti inflammatory drug) that is routinely used in opthamology to control pain following cataract surgery.
Related Catalog	Research Areas >> Inflammation/Immunology
Target	COX-1:64.3 μM (IC50) COX-2
References	[1]. Gamache DA, Graff G, Brady MT et al. Nepafenac, a unique nonsteroidal prodrug with potential utility in the treatment of trauma-induced ocular inflammation: I. Assessment of anti-inflammatory efficacy. Inflammation. 2000 Aug;24(4):357-70. [2]. Ke TL, Graff G, Spellman JM, Yanni JM. Nepafenac, a unique nonsteroidal prodrug with potential utility in the treatment of trauma-induced ocular inflammation: II. In vitro bioactivation and permeation of external ocular barriers. Inflammation. 2000 Aug;24(4):371-84. [3]. Lindstrom R, Kim T. Ocular permeation and inhibition of retinal inflammation: an examination of data and expert opinion on the clinical utility of nepafenac. Curr Med Res Opin. 2006 Feb;22(2):397-404. [4]. Marshall JC, Fernandes BF, Di Cesare S et al. The use of a cyclooxygenase-2 inhibitor (Nepafenac) in an ocular and metastatic animal model of uveal melanoma. Carcinogenesis. 2007 Sep;28(9):2053-8. [5]. Singh R, Alpern L, Jaffe GJ et al. Evaluation of nepafenac in prevention of macular edema following cataract surgery in patients with diabetic retinopathy. Clin Ophthalmol. 2012;6:1259-69.

Density	1.3±0.1 g/cm3
Boiling Point	562.5±50.0 °C at 760 mmHg
Melting Point	177-181ºC
Molecular Formula	C₁₅H₁₄N₂O₂
Molecular Weight	254.284
Flash Point	294.0±30.1 °C
Exact Mass	254.105530
PSA	86.18000
LogP	0.73
Vapour Pressure	0.0±1.5 mmHg at 25°C
Index of Refraction	1.641
Storage condition	Refrigerator

Nepafenac MSDS(Chinese)

Symbol	GHS09
Signal Word	Warning
Hazard Statements	H400
Precautionary Statements	P273
Hazard Codes	N
Risk Phrases	50/53
Safety Phrases	60-61
RIDADR	UN 3077 9 / PGIII
HS Code	2924299090

2-Amino-3-benzo...

CAS#:78281-61-5

~84%

Nepafenac

CAS#:78281-72-8

Literature: Medichem, S.A. Patent: US2009/312575 A1, 2009 ; Location in patent: Page/Page column 5-6 ;

2-Aminobenzophenone

CAS#:2835-77-0

Nepafenac

CAS#:78281-72-8

Literature: Journal of Medicinal Chemistry, , vol. 33, # 8 p. 2296 - 2304

N/A

CAS#:173262-94-7

Nepafenac

CAS#:78281-72-8

Literature: US5475034 A1, ;

Precursor 2
CAS#:78281-61-5 2-Amino-3-benzo... CAS#:2835-77-0 2-Aminobenzophenone
DownStream 0

HS Code	2924299090
Summary	2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Use of nepafenac (Nevanac) in combination with intravitreal anti-VEGF agents in the treatment of recalcitrant exudative macular degeneration requiring monthly injections.

Clin. Ophthalmol. 4 , 1249-52, (2010)

The purpose of this study is to determine the efficacy of combining topical nepafenac with monthly intravitreal injections of ranibizumab or bevacizumab in the treatment of recalcitrant exudative macu...

Benzeneacetamide, 2-amino-3-benzoyl-

Nevanac

2-(2-Amino-3-benzoylphenyl)acetamide

Nepafenac

Nepafanac

2-Amino-3-benzoylbenzeneacetamide

2-[2-amino-3-(phénylcarbonyl)phényl]acétamide

AL 6515

AHR 9434

2-[2-Amino-3-(phenylcarbonyl)phenyl]acetamid

2-[2-amino-3-(phenylcarbonyl)phenyl]acetamide

2-Amino-3-benzoyl-phenylacetamide

DC Chemicals Limited
China
Product Name: Nepafenac
Price: $250.0/100mg $500.0/250mg $1000.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Zhejiang Hangyu API Co., Ltd
China
Product Name: Nepafenac
Price: ￥Inquiry/1kg
Purity: 99.5%
Stocking Period: Inquiry
Contact: Vinnie

Henan Tianfu Chemical Co., Ltd.
China
Product Name: nepafenac
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

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Price: $66/10mM*1mLinDMSO

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Nepafenac

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