BIM-23027
Modify Date: 2024-04-05 18:43:28
BIM-23027 structure
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Common Name | BIM-23027 | ||
|---|---|---|---|---|
| CAS Number | 78981-49-4 | Molecular Weight | 794.94 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C43H54N8O7 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of BIM-23027BIM-23027 is a selective agonist of sst2 receptor (EC50=0.32 nM), with similar effect to somatostatin (SRIF), a cyclic tetradecapeptide. BIM-23027 stimulates dopamine release, which is mediated by a Glu-dependent mechanism[1][2]. |
| Name | BIM-23027 |
|---|
| Description | BIM-23027 is a selective agonist of sst2 receptor (EC50=0.32 nM), with similar effect to somatostatin (SRIF), a cyclic tetradecapeptide. BIM-23027 stimulates dopamine release, which is mediated by a Glu-dependent mechanism[1][2]. |
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| Related Catalog | |
| Target |
EC50: 0.32 nM (sst2)[2] |
| In Vitro | BIM-23027 (10,50 和 100 nM; 90分钟) 显著增加多巴胺水平[1]。 BIM-23027 (50 nM; 100 nM SRIF 处理前 15 分钟孵育) 显著减弱了天然肽的作用[1]。 BIM-23027 (30 nM; 30 分钟) 卡威酚刺激的基底鳞状细胞增加 60-70%，EC50 为 0.29 nM[2]。 BIM-23027 与大鼠结肠粘膜 [125I]Tyr11-SRIF 结合位点的亚群相互作用[2]。 |
| References |
| Molecular Formula | C43H54N8O7 |
|---|---|
| Molecular Weight | 794.94 |