78981-49-4

78981-49-4 structure

Name: BIM-23027
Chemical Name: BIM-23027
CAS Number: 78981-49-4
Molecular Formula: C₄₃H₅₄N₈O₇
Molecular Weight: 794.94
Catalog: Research Areas Neurological Disease
Create Date: 2023-03-07 10:05:29
Modify Date: 2024-04-05 18:43:28
BIM-23027 is a selective agonist of sst2 receptor (EC50=0.32 nM), with similar effect to somatostatin (SRIF), a cyclic tetradecapeptide. BIM-23027 stimulates dopamine release, which is mediated by a Glu-dependent mechanism[1][2].

Name	BIM-23027

Description	BIM-23027 is a selective agonist of sst2 receptor (EC50=0.32 nM), with similar effect to somatostatin (SRIF), a cyclic tetradecapeptide. BIM-23027 stimulates dopamine release, which is mediated by a Glu-dependent mechanism[1][2].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
Target	EC50: 0.32 nM (sst2)[2]
In Vitro	BIM-23027 (10,50 和 100 nM; 90分钟) 显著增加多巴胺水平[1]。 BIM-23027 (50 nM; 100 nM SRIF 处理前 15 分钟孵育) 显著减弱了天然肽的作用[1]。 BIM-23027 (30 nM; 30 分钟) 卡威酚刺激的基底鳞状细胞增加 60-70%，EC50 为 0.29 nM[2]。 BIM-23027 与大鼠结肠粘膜 [125I]Tyr11-SRIF 结合位点的亚群相互作用[2]。
References	[1]. Hathway GJ, et al. Evidence that somatostatin sst2 receptors mediate striatal dopamine release. Br J Pharmacol. 1999 Nov;128(6):1346-52. [2]. McKeen ES, et al. Somatostatin receptors mediating inhibition of basal and stimulated electrogenic ion transport in rat isolated distal colonic mucosa. Naunyn Schmiedebergs Arch Pharmacol. 1995 Oct;352(4):402-11.

Molecular Formula	C₄₃H₅₄N₈O₇
Molecular Weight	794.94