ML-T531

Modify Date: 2024-08-26 13:40:59

ML-T531 Structure
ML-T531 structure
Common Name ML-T531
CAS Number 791127-70-3 Molecular Weight 332.359
Density N/A Boiling Point N/A
Molecular Formula C20H16N2O3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of ML-T531


A potent, selective hERG potassium channel (Kv11.1) activator with EC50 of 3.13 uM; exhibits no potentiation for KCNQ1 and KCNE1, and no noticeable effects on other cardiac channels including Cav1.2, Kir2.1, Nav1.5, and Kv4.3; significantly potentiates hERG steady-state currents and tail currents in CHO cells at 10 uM, enhances voltage-dependent potassium current amplitudes in the presence of an Iks-specific inhibitor chromanol 293B; potentiates native potassium currents in iPSC-derived cardiomyocytes, shortens the APD90 of LQT1 cardiomyocytes with EC50 of 5.71 uM, normalizes the disease phenotype of cardiomycytes derived from a patient with LQT1.

 Names

Name ML-T531

 ML-T531 Biological Activity

Description A potent, selective hERG potassium channel (Kv11.1) activator with EC50 of 3.13 uM; exhibits no potentiation for KCNQ1 and KCNE1, and no noticeable effects on other cardiac channels including Cav1.2, Kir2.1, Nav1.5, and Kv4.3; significantly potentiates hERG steady-state currents and tail currents in CHO cells at 10 uM, enhances voltage-dependent potassium current amplitudes in the presence of an Iks-specific inhibitor chromanol 293B; potentiates native potassium currents in iPSC-derived cardiomyocytes, shortens the APD90 of LQT1 cardiomyocytes with EC50 of 5.71 uM, normalizes the disease phenotype of cardiomycytes derived from a patient with LQT1.
References References 1. Zhang H, et al. Proc Natl Acad Sci U S A. 2012 Jul 17;109(29):11866-71. 2. Yu Z, et al. Eur J Med Chem. 2015 Dec 1;106:50-9. 3. Yu Z, et al. Circ Arrhythm Electrophysiol. 2016 Apr;9(4):e003439. View Related Products by Target Potassium Channel

 Chemical & Physical Properties

Molecular Formula C20H16N2O3
Molecular Weight 332.359