ML 382
Modify Date: 2024-01-17 22:06:04
ML 382 structure
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Common Name | ML 382 | ||
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| CAS Number | 1646499-97-9 | Molecular Weight | 360.427 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C18H20N2O4S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of ML 382ML382 is a potent, selective, positive allosteric modulator of Mas-related G protein-coupled receptor X1 (MrgprX1) with EC50 of 190 nM in cell based Ca2+ imaging assay; displays >100-fold selectivity versus MrgX2; enhances the ability of BAM8-22 to inhibit high-voltage-activated Ca2+ channels and attenuates spinal nociceptive transmission; effectively attenuated evoked, persistent, and spontaneous pain without causing obvious side effects; attenuates both evoked pain hypersensitivity and spontaneous pain in MrgprX1 mice; an invaluable research tool to study the role of MrgprX1 in chronic pain. |
| Name | 2-[(Cyclopropylsulfonyl)amino]-N-(2-ethoxyphenyl)benzamide |
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| Synonym | More Synonyms |
| Description | ML382 is a potent, selective, positive allosteric modulator of Mas-related G protein-coupled receptor X1 (MrgprX1) with EC50 of 190 nM in cell based Ca2+ imaging assay; displays >100-fold selectivity versus MrgX2; enhances the ability of BAM8-22 to inhibit high-voltage-activated Ca2+ channels and attenuates spinal nociceptive transmission; effectively attenuated evoked, persistent, and spontaneous pain without causing obvious side effects; attenuates both evoked pain hypersensitivity and spontaneous pain in MrgprX1 mice; an invaluable research tool to study the role of MrgprX1 in chronic pain. |
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| References | References 1. Wen W, et al. ChemMedChem. 2015 Jan;10(1):57-61. 2. Li Z, et al. Proc Natl Acad Sci U S A. 2017 Mar 7;114(10):E1996-E2005. View Related Products by Target Other Targets |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Molecular Formula | C18H20N2O4S |
| Molecular Weight | 360.427 |
| Exact Mass | 360.114380 |
| LogP | 3.27 |
| Index of Refraction | 1.631 |
| MFCD30182354 |
| Benzamide, 2-[(cyclopropylsulfonyl)amino]-N-(2-ethoxyphenyl)- |
| 2-[(Cyclopropylsulfonyl)amino]-N-(2-ethoxyphenyl)benzamide |