PBP 10

Modify Date: 2025-09-19 08:41:42

PBP 10 Structure
PBP 10 structure
Common Name PBP 10
CAS Number 794466-43-6 Molecular Weight 1713.06
Density N/A Boiling Point N/A
Molecular Formula C84H127N24O15 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of PBP 10


PBP10 is a cell permeable and selective gelsolin-derived peptide inhibitor of formyl peptide receptor 2 (FPR2) over FPR1[1]. PBP10 is a 10-AA peptide with rhodamine conjugated at its N terminus, exerts bactericidal activity against gram-positive and gram-negative bacteria and limits microbial-induced inflammatory effects[2].

 Names

Name PBP10

 PBP 10 Biological Activity

Description PBP10 is a cell permeable and selective gelsolin-derived peptide inhibitor of formyl peptide receptor 2 (FPR2) over FPR1[1]. PBP10 is a 10-AA peptide with rhodamine conjugated at its N terminus, exerts bactericidal activity against gram-positive and gram-negative bacteria and limits microbial-induced inflammatory effects[2].
Related Catalog
Target

IC50: formyl peptide receptor 2 (FPR2)[1]

References

[1]. C C Cunningham, et al.Cell permeant polyphosphoinositide-binding peptides that block cell motility and actin assembly. J Biol Chem

[2]. Ewelina Piktel, et al. Inhibition of inflammatory response in human keratinocytes by magnetic nanoparticles functionalized with PBP10 peptide derived from the PIP2-binding site of human plasma gelsolin. J Nanobiotechnology. 2019 Feb 2;17(1):22.

 Chemical & Physical Properties

Molecular Formula C84H127N24O15
Molecular Weight 1713.06
InChIKey XKUIQFSLYNIFAC-XADHZNKISA-N
SMILES CCN(CC)c1ccc2c(-c3ccccc3C(=O)NC(CCC(N)=O)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC(C)C)C(=O)NC(Cc3ccccc3)C(=O)NC(CCC(N)=O)C(=O)NC(C(=O)NC(CCCCN)C(=O)NCC(=O)NC(CCCNC(=N)N)C(=O)NC(CCCNC(=N)N)C(=O)O)C(C)C)c3ccc(N(CC)CC)cc3[o+]c2c1.[Cl-]
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