Brevetoxin2(PbTx-2)

Modify Date: 2024-01-05 11:42:17

Brevetoxin2(PbTx-2) structure	Common Name	Brevetoxin2(PbTx-2)
	CAS Number	79580-28-2	Molecular Weight	895.08200
	Density	1.188g/cm3	Boiling Point	N/A
	Molecular Formula	C₅₀H₇₀O₁₄	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Brevetoxin2(PbTx-2)

Brevetoxin B (Brevetoxin-2; PbTx-2) is a polyketide neurotoxin produced by Karenia species and other dinoflagellates. Brevetoxin B binds to site 5 on the alpha subunit of voltage-gated sodium channels (IC50=15 nM) on neurons at the neuromuscular junction, causing the channel to open irreversibly at potentials more negative than normal, discharging action potentials repetitively. Brevetoxin B is ichthyotoxic at nanomolar concentrations and is responsible for an illness described as neurotoxic shellfish poisoning.

Name	brevetoxin b
Synonym	More Synonyms

Description	Brevetoxin B (Brevetoxin-2; PbTx-2) is a polyketide neurotoxin produced by Karenia species and other dinoflagellates. Brevetoxin B binds to site 5 on the alpha subunit of voltage-gated sodium channels (IC50=15 nM) on neurons at the neuromuscular junction, causing the channel to open irreversibly at potentials more negative than normal, discharging action potentials repetitively. Brevetoxin B is ichthyotoxic at nanomolar concentrations and is responsible for an illness described as neurotoxic shellfish poisoning.
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel

Description

Related Catalog

Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel

Density	1.188g/cm3
Molecular Formula	C₅₀H₇₀O₁₄
Molecular Weight	895.08200
Exact Mass	894.47700
PSA	155.90000
LogP	5.47210
Index of Refraction	1.522

Brevetoxin2(PbTx-2) MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XW5886000

CHEMICAL NAME :: Toxin T-34

CAS REGISTRY NUMBER :: 79580-28-2

LAST UPDATED :: 198909

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C50-H70-O14

MOLECULAR WEIGHT :: 895.20

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 6600 ug/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - fasciculations Behavioral - tremor Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: TOXIA6 Toxicon. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW, UK) V.1- 1962- Volume(issue)/page/year: 20,457,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 200 ug/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - fasciculations Behavioral - tremor Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: TOXIA6 Toxicon. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW, UK) V.1- 1962- Volume(issue)/page/year: 20,457,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 200 ug/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - fasciculations Behavioral - tremor Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: TOXIA6 Toxicon. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW, UK) V.1- 1962- Volume(issue)/page/year: 20,457,1982

Hazard Codes	T+: Very toxic;
Risk Phrases	26/27/28
Safety Phrases	22-36/37/39-45
RIDADR	UN 2811 6.1/PG 2
Hazard Class	6.1(a)

Brevetoxin-3

CAS#:85079-48-7

Brevetoxin2(PbTx-2)

CAS#:79580-28-2

Literature: Kadota, Isao; Takamura, Hiroyoshi; Nishii, Hiroki; Yamamoto, Yoshinori Journal of the American Chemical Society, 2005 , vol. 127, # 25 p. 9246 - 9250

Precursor 1
CAS#:85079-48-7 Brevetoxin-3
DownStream 0

brevetoxin-B

gb2

btx-b

PBTX-2

toxint-34

t4-7

GBTX-2

t4-7toxin

gb2toxin

BREVETOXIN 2

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Brevetoxin2（PbTx-2）
Price: Click To Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: Brevetoxin B
Price: $Inquiry/250mg $Inquiry/100mg $Inquiry/1g
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

Get all suppliers and price by the below link:

Brevetoxin2(PbTx-2) suppliers

Brevetoxin2(PbTx-2) price

Brevetoxin2(PbTx-2)

Use of Brevetoxin2(PbTx-2)

Names