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79580-28-2

79580-28-2 structure
79580-28-2 structure
  • Name: Brevetoxin2(PbTx-2)
  • Chemical Name: brevetoxin b
  • CAS Number: 79580-28-2
  • Molecular Formula: C50H70O14
  • Molecular Weight: 895.08200
  • Catalog: Signaling Pathways Membrane Transporter/Ion Channel Sodium Channel
  • Create Date: 2018-09-10 16:32:18
  • Modify Date: 2024-01-05 11:42:17
  • Brevetoxin B (Brevetoxin-2; PbTx-2) is a polyketide neurotoxin produced by Karenia species and other dinoflagellates. Brevetoxin B binds to site 5 on the alpha subunit of voltage-gated sodium channels (IC50=15 nM) on neurons at the neuromuscular junction, causing the channel to open irreversibly at potentials more negative than normal, discharging action potentials repetitively. Brevetoxin B is ichthyotoxic at nanomolar concentrations and is responsible for an illness described as neurotoxic shellfish poisoning.

Name brevetoxin b
Synonyms brevetoxin-B
gb2
btx-b
PBTX-2
toxint-34
t4-7
GBTX-2
t4-7toxin
gb2toxin
BREVETOXIN 2
Description Brevetoxin B (Brevetoxin-2; PbTx-2) is a polyketide neurotoxin produced by Karenia species and other dinoflagellates. Brevetoxin B binds to site 5 on the alpha subunit of voltage-gated sodium channels (IC50=15 nM) on neurons at the neuromuscular junction, causing the channel to open irreversibly at potentials more negative than normal, discharging action potentials repetitively. Brevetoxin B is ichthyotoxic at nanomolar concentrations and is responsible for an illness described as neurotoxic shellfish poisoning.
Related Catalog
Density 1.188g/cm3
Molecular Formula C50H70O14
Molecular Weight 895.08200
Exact Mass 894.47700
PSA 155.90000
LogP 5.47210
Index of Refraction 1.522

CHEMICAL IDENTIFICATION

RTECS NUMBER :
XW5886000
CHEMICAL NAME :
Toxin T-34
CAS REGISTRY NUMBER :
79580-28-2
LAST UPDATED :
198909
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C50-H70-O14
MOLECULAR WEIGHT :
895.20

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
6600 ug/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - fasciculations Behavioral - tremor Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
TOXIA6 Toxicon. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW, UK) V.1- 1962- Volume(issue)/page/year: 20,457,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
200 ug/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - fasciculations Behavioral - tremor Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
TOXIA6 Toxicon. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW, UK) V.1- 1962- Volume(issue)/page/year: 20,457,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
200 ug/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - fasciculations Behavioral - tremor Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
TOXIA6 Toxicon. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW, UK) V.1- 1962- Volume(issue)/page/year: 20,457,1982
Hazard Codes T+: Very toxic;
Risk Phrases 26/27/28
Safety Phrases 22-36/37/39-45
RIDADR UN 2811 6.1/PG 2
Hazard Class 6.1(a)

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79580-28-2 structure

79580-28-2

Literature: Kadota, Isao; Takamura, Hiroyoshi; Nishii, Hiroki; Yamamoto, Yoshinori Journal of the American Chemical Society, 2005 , vol. 127, # 25 p. 9246 - 9250
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