Name | brevetoxin b |
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Synonyms |
brevetoxin-B
gb2 btx-b PBTX-2 toxint-34 t4-7 GBTX-2 t4-7toxin gb2toxin BREVETOXIN 2 |
Description | Brevetoxin B (Brevetoxin-2; PbTx-2) is a polyketide neurotoxin produced by Karenia species and other dinoflagellates. Brevetoxin B binds to site 5 on the alpha subunit of voltage-gated sodium channels (IC50=15 nM) on neurons at the neuromuscular junction, causing the channel to open irreversibly at potentials more negative than normal, discharging action potentials repetitively. Brevetoxin B is ichthyotoxic at nanomolar concentrations and is responsible for an illness described as neurotoxic shellfish poisoning. |
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Related Catalog |
Density | 1.188g/cm3 |
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Molecular Formula | C50H70O14 |
Molecular Weight | 895.08200 |
Exact Mass | 894.47700 |
PSA | 155.90000 |
LogP | 5.47210 |
Index of Refraction | 1.522 |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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Hazard Codes | T+: Very toxic; |
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Risk Phrases | 26/27/28 |
Safety Phrases | 22-36/37/39-45 |
RIDADR | UN 2811 6.1/PG 2 |
Hazard Class | 6.1(a) |
~% 79580-28-2 |
Literature: Kadota, Isao; Takamura, Hiroyoshi; Nishii, Hiroki; Yamamoto, Yoshinori Journal of the American Chemical Society, 2005 , vol. 127, # 25 p. 9246 - 9250 |
Precursor 1 | |
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DownStream 0 |