Methoxsalen-d3

Modify Date: 2024-01-31 02:34:38

Methoxsalen-d3 Structure
Methoxsalen-d3 structure
Common Name Methoxsalen-d3
CAS Number 80386-99-8 Molecular Weight 219.20800
Density N/A Boiling Point N/A
Molecular Formula C12H5D3O4 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Methoxsalen-d3


Methoxsalen-d3 is the deuterium labeled Methoxsalen[1]. Methoxsalen (8-Methoxypsoralen) is a potent tricyclic furocoumarin suicide inhibitor of CYP (cytochrome P-450), is an agent used to treat psoriasis, eczema, vitiligo and some cutaneous Lymphomas in conjunction with exposing the skin to sunlight[2].

 Names

Name 9-[(2H3)Methyloxy]-7H-furo[3,2-g]chromen-7-one

 Methoxsalen-d3 Biological Activity

Description Methoxsalen-d3 is the deuterium labeled Methoxsalen[1]. Methoxsalen (8-Methoxypsoralen) is a potent tricyclic furocoumarin suicide inhibitor of CYP (cytochrome P-450), is an agent used to treat psoriasis, eczema, vitiligo and some cutaneous Lymphomas in conjunction with exposing the skin to sunlight[2].
Related Catalog
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  

[2]. Alsharari SD, et al. Pharmacokinetic and Pharmacodynamics Studies of Nicotine After Oral Administration in Mice: Effects of Methoxsalen, a CYP2A5/6 Inhibitor. Nicotine Tob Res. 2014 Jan;16(1):18-25.  

 Chemical & Physical Properties

Molecular Formula C12H5D3O4
Molecular Weight 219.20800
Exact Mass 219.06100
PSA 52.58000
LogP 2.54780