Notoginsenoside R1
Notoginsenoside R1 structure
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Common Name | Notoginsenoside R1 | ||
|---|---|---|---|---|
| CAS Number | 80418-24-2 | Molecular Weight | 933.127 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 1010.5±65.0 °C at 760 mmHg | |
| Molecular Formula | C47H80O18 | Melting Point | 218 °C | |
| MSDS | Chinese USA | Flash Point | 564.9±34.3 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of Notoginsenoside R1Notoginsenoside R1, the main bioactive component in panaxnotoginseng, is reported to have some neuronal protective, antihypertensive effects. IC50 value:Target:In vitro:In vivo: Notoginsenoside R1 significantly reduce blood pressure in spontaneously hypertensive rats and induce nitric oxide generation through increasing the phosphorylation of iNOS. Notoginsenoside R1 reduces the caudal blood pressure of spontaneously hypertensive rats through induction of iNOS regulated by long non-coding RNA AK094457 [1]. The mice with notoginsenoside R1 treatment showed significant amelioration in the cognitive function and increased choline acetyl transferase expression, as compared to the vehicle treated mice. Notoginsenoside R1 treatment inhibited Aβ accumulation and increased insulin degrading enzyme expression in both APP/PS1 mice and N2a-APP695sw cells [2]. In Notoginsenoside R1 treated rats, expression of TGF-β1and Smad3 at each time point was down-regulated, with statistical significance(P0.05) compared with that in the NDMA group [3]. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | notoginsenoside R1 |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | Notoginsenoside R1, the main bioactive component in panaxnotoginseng, is reported to have some neuronal protective, antihypertensive effects. IC50 value:Target:In vitro:In vivo: Notoginsenoside R1 significantly reduce blood pressure in spontaneously hypertensive rats and induce nitric oxide generation through increasing the phosphorylation of iNOS. Notoginsenoside R1 reduces the caudal blood pressure of spontaneously hypertensive rats through induction of iNOS regulated by long non-coding RNA AK094457 [1]. The mice with notoginsenoside R1 treatment showed significant amelioration in the cognitive function and increased choline acetyl transferase expression, as compared to the vehicle treated mice. Notoginsenoside R1 treatment inhibited Aβ accumulation and increased insulin degrading enzyme expression in both APP/PS1 mice and N2a-APP695sw cells [2]. In Notoginsenoside R1 treated rats, expression of TGF-β1and Smad3 at each time point was down-regulated, with statistical significance(P0.05) compared with that in the NDMA group [3]. |
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| Related Catalog | |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 1010.5±65.0 °C at 760 mmHg |
| Melting Point | 218 °C |
| Molecular Formula | C47H80O18 |
| Molecular Weight | 933.127 |
| Flash Point | 564.9±34.3 °C |
| Exact Mass | 932.534485 |
| PSA | 298.14000 |
| LogP | 4.42 |
| Appearance of Characters | white to off-white |
| Vapour Pressure | 0.0±0.6 mmHg at 25°C |
| Index of Refraction | 1.614 |
| InChIKey | LLPWNQMSUYAGQI-OOSPGMBYSA-N |
| SMILES | CC(C)=CCCC(C)(OC1OC(CO)C(O)C(O)C1O)C1CCC2(C)C1C(O)CC1C3(C)CCC(O)C(C)(C)C3C(OC3OC(CO)C(O)C(O)C3OC3OCC(O)C(O)C3O)CC12C |
| Storage condition | 2-8°C |
| Water Solubility | H2O: soluble1mg/mL, clear, colorless |
This table lists relevant public references with title, journal and publication metadata for this compound.
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Protective effect of panax notoginseng saponins on acute ethanol-induced liver injury is associated with ameliorating hepatic lipid accumulation and reducing ethanol-mediated oxidative stress.
J. Agric. Food Chem. 63(9) , 2413-22, (2015) The aim of present study was to evaluate the effects of Panax notoginseng saponins (PNS) against acute ethanol-induced liver injury and further to elucidate its probable mechanisms. Mice were treated ... |
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A comparative study of using in-line near-infrared spectra, ultraviolet spectra and fused spectra to monitor Panax notoginseng adsorption process.
J. Pharm. Biomed. Anal. 102 , 78-84, (2014) The step of enriching and purifying saponins by macroporous resin column chromatography is closely related to the safety and efficacy of Panax notoginseng products during their manufacturing processes... |
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Adulteration and cultivation region identification of American ginseng using HPLC coupled with multivariate analysis.
J. Pharm. Biomed. Anal. 99 , 8-15, (2014) American ginseng (Panax quinquefolius) is originally grown in North America. Due to price difference and supply shortage, American ginseng recently has been cultivated in northern China. Further, in t... |
This table contains target information, in‑vitro & in‑vivo assay data for this compound.
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Name: Induction of neurite outgrowth in human SK-N-SH cells at 100 uM after 5 days relative...
Source: ChEMBL
Target: SK-N-SH
External Id: CHEMBL1034181
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Name: Hepatoprotective activity against D-galactosamine/LPS-induced liver injury in ddY mou...
Source: ChEMBL
Target: Mus musculus
External Id: CHEMBL1016626
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Name: Hepatoprotective activity against D-galactosamine/LPS-induced liver injury in ddY mou...
Source: ChEMBL
Target: Mus musculus
External Id: CHEMBL1015786
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This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| notoginsenoside Rh1 |
| Sanchinoside R1 |
| NOTOGINSENOSIDE |
| notogisenoside R1 |
| Notoginsenoside R1 |
| (3β,6α,12β)-20-(β-D-Glucopyranosyloxy)-3,12-dihydroxydammar-24-en-6-yl 2-O-β-D-xylopyranosyl-β-D-glucopyranoside |
| ginsenoside-Rg2 |
| NotoginsenosideR1 |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What is the physical appearance of notoginsenoside R1? |
| A: notoginsenoside R1 appears as white to off-white. |
| Q: What is the CAS number of notoginsenoside R1? |
| A: CAS number of notoginsenoside R1 is 80418-24-2. |
| Q: What is the melting point of notoginsenoside R1? |
| A: Melting point of notoginsenoside R1 is 218 °C. |
| Q: What are the storage conditions for notoginsenoside R1? |
| A: Storage conditions for notoginsenoside R1: 2-8°C. |
| Q: What is the InChIKey of notoginsenoside R1? |
| A: InChIKey of notoginsenoside R1 is LLPWNQMSUYAGQI-OOSPGMBYSA-N. |
| Q: What is the molecular weight of notoginsenoside R1? |
| A: Molecular weight of notoginsenoside R1 is 933.127. |
| Q: What is the SMILES notation of notoginsenoside R1? |
| A: SMILES notation of notoginsenoside R1 is CC(C)=CCCC(C)(OC1OC(CO)C(O)C(O)C1O)C1CCC2(C)C1C(O)CC1C3(C)CCC(O)C(C)(C)C3C(OC3OC(CO)C(O)C(O)C3OC3OCC(O)C(O)C3O)CC12C. |
| Q: What is the boiling point of notoginsenoside R1? |
| A: Boiling point of notoginsenoside R1 is 1010.5±65.0 °C at 760 mmHg. |
| Q: What is the safety information for notoginsenoside R1? |
| A: Safety information for notoginsenoside R1: 24/25. |
| Q: What is the molecular formula of notoginsenoside R1? |
| A: Molecular formula of notoginsenoside R1 is C47H80O18. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| BioBioPha |
| Dayang Chem (Hangzhou) Co., Ltd. |
| naturewill |