ACRIFLAVINE

Modify Date: 2024-01-02 11:56:26

ACRIFLAVINE Structure
ACRIFLAVINE structure
 Common Name ACRIFLAVINE
CAS Number 8048-52-0 Molecular Weight 259.73
Density N/A Boiling Point N/A
Molecular Formula C14H14ClN3 Melting Point 179-181 °C
MSDS Chinese USA Flash Point N/A
Symbol GHS07
GHS07		 Signal Word Warning

 Use of ACRIFLAVINE


Acriflavine is a fluorescent dye for labeling high molecular weight RNA. It is also a topical antiseptic.

 Names

Name acriflavine
Synonym More Synonyms

 ACRIFLAVINE Biological Activity

Description Acriflavine is a fluorescent dye for labeling high molecular weight RNA. It is also a topical antiseptic.
Related Catalog
In Vitro Acriflavine is identified as a potent inhibitor of the MCT4 that can inhibit the binding between Basigin and MCT4. Acriflavine significantly inhibits growth and self-renewal potential of several glioblastoma neurosphere lines[1]. The HIF-1 inhibitor acriflavine decreases survival and growth of CML cells. It targets stem cell potential of CML cells[2].
In Vivo Acriflavine treatment inhibits intratumoral expression of VEGF and tumor vascularization[1]. In a murine CML model, acriflavine decreases leukemia development and reduces LSC maintenance[2]. Acriflavine retards tumor growth in a murine model of breast cancer. The combination of sunitinib with acriflavine significantly decreases vascular endothelial growth factor and TGF-β expression and reduces tumor vasculature followed by increased intratumor necrosis and apoptosis[3].
Animal Admin Mice: CML mice are treated daily with acriflavine (8 mg/kg) or PBS via intraperitoneal injection, for 10 days starting from day 7 after bone marrow transplantation[2].
References

[1]. Voss DM, et al. Disruption of the monocarboxylate transporter-4-basigin interaction inhibits the hypoxic response, proliferation, and tumor progression. Sci Rep. 2017 Jun 27;7(1):4292.

[2]. Cheloni G, et al. Targeting chronic myeloid leukemia stem cells with the hypoxia-inducible factor inhibitor acriflavine. Blood. 2017 Jun 2. pii: blood-2016-10-745588.

[3]. Yin T, et al. HIF-1 Dimerization Inhibitor Acriflavine Enhances Antitumor Activity of Sunitinib in Breast Cancer Model. Oncol Res. 2014;22(3):139-45.

 Chemical & Physical Properties

Melting Point 179-181 °C
Molecular Formula C14H14ClN3
Molecular Weight 259.73
PSA 120.85000
LogP 3.86310

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
AR9660000
CHEMICAL NAME :
Acridinium, 3,6-diamino-10-methyl-, chloride mixed with 3,6-acridinediamine
CAS REGISTRY NUMBER :
8048-52-0
LAST UPDATED :
199706
DATA ITEMS CITED :
18
MOLECULAR FORMULA :
C14-H14-N3.Cl.C13-H11-N3
MOLECULAR WEIGHT :
469.03
WISWESSER LINE NOTATION :
T C666 BKJ B1 EZ MZ &G &T C666 BNJ EZ MZ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
160 mg/kg/60W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Tumorigenic - tumors at site of application
TYPE OF TEST :
Dominant lethal test

MUTATION DATA

TYPE OF TEST :
Morphological transformation
TEST SYSTEM :
Rodent - hamster Kidney
DOSE/DURATION :
25 mg/L
REFERENCE :
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 19,55,1981 *** REVIEWS *** IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 13,31,1977 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 13,31,1977 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X1531 No. of Facilities: 10 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 40 (estimated) No. of Female Employees: 10 (estimated)

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302-H315-H319-H335
Precautionary Statements P261-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xn:Harmful;N:Dangerousfortheenvironment;
Risk Phrases R22;R37/38;R41;R50/53
Safety Phrases S26-S39-S60-S61
RIDADR UN 3077 9/PG 3
WGK Germany 3
RTECS AR9660000
HS Code 38249064

 Customs

HS Code 38249064

 Articles41

More Articles
Bilobalide attenuates hypoxia induced oxidative stress, inflammation, and mitochondrial dysfunctions in 3T3-L1 adipocytes via its antioxidant potential.

Free Radic. Res. 48(10) , 1206-17, (2014)

Excessive expansion of white adipose tissue leads to hypoxia which is considered as a key factor responsible for adipose tissue dysfunction in obesity. Hypoxia induces inflammation, insulin resistance...

Vacuolar ATPase depletion affects mitochondrial ATPase function, kinetoplast dependency, and drug sensitivity in trypanosomes.

Proc. Natl. Acad. Sci. U. S. A. 112 , 9112-7, (2015)

Kinetoplastid parasites cause lethal diseases in humans and animals. The kinetoplast itself contains the mitochondrial genome, comprising a huge, complex DNA network that is also an important drug tar...

The efflux pump inhibitor timcodar improves the potency of antimycobacterial agents.

Antimicrob. Agents Chemother. 59(3) , 1534-41, (2015)

Previous studies indicated that inhibition of efflux pumps augments tuberculosis therapy. In this study, we used timcodar (formerly VX-853) to determine if this efflux pump inhibitor could increase th...

 Synonyms

ACRIFLAVINE
EUFLAVINE
3,6-Diamino-10-methylacridinium chloride - 3,6-acridinediamine (1:1:1)
3,6-Diamino-10-methylacridinium Chloride mixt with 3,6-Acridine Diamine
3,6-Diamino-10-methylacridinium chloride 3,6-acridinediamine (1:1:1)
diacrid
3,6-Diamino-10-methylacridinium chloride 3,6-acridinediamine (1:1)
flavipin
Trypaflavine
Acridinium, 3,6-diamino-10-methyl-, chloride, mixt. with 3,6-acridinediamine
gonacin
3,6-Diamino-10-methylacridinium chloride - acridine-3,6-diamine (1:1:1)
flavine
Neutroflavine
EUFLAVIN
angiflan
Neutral Acriflavine
flavisept
isravin
MFCD00064307
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Related Compounds: More...
Acriflavine
65589-70-0
ACRIFLAVINE HCL
8063-24-9
Acriflavine hydrochloride
69235-50-3
Acriflavine (component of)
86-40-8
Chemsrc provides ACRIFLAVINE(CAS#:8048-52-0) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of ACRIFLAVINE are included as well.>> amp version: ACRIFLAVINE

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