Dexpanthenol

Modify Date: 2024-01-02 12:47:57

Dexpanthenol Structure
Dexpanthenol structure
Common Name Dexpanthenol
CAS Number 81-13-0 Molecular Weight 205.251
Density 1.2±0.1 g/cm3 Boiling Point 483.6±45.0 °C at 760 mmHg
Molecular Formula C9H19NO4 Melting Point N/A
MSDS Chinese USA Flash Point 246.3±28.7 °C

 Use of Dexpanthenol


D-Panthenol is the biologically-active alcohol of pantothenic acid, which leads to an elevation in the amount of coenzyme A in the cell.

 Names

Name pantothenol
Synonym More Synonyms

 Dexpanthenol Biological Activity

Description D-Panthenol is the biologically-active alcohol of pantothenic acid, which leads to an elevation in the amount of coenzyme A in the cell.
Related Catalog
References

[1]. Oguz A, et al. Topical N-acetylcysteine improves wound healing comparable to dexpanthenol: an experimental study. Int Surg. 2015 Apr;100(4):656-61.

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 483.6±45.0 °C at 760 mmHg
Molecular Formula C9H19NO4
Molecular Weight 205.251
Flash Point 246.3±28.7 °C
Exact Mass 205.131409
PSA 89.79000
LogP -0.92
Vapour Pressure 0.0±2.8 mmHg at 25°C
Index of Refraction 1.502

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
ES4316000
CHEMICAL NAME :
Butyramide, 2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethyl-, D-(+)-
CAS REGISTRY NUMBER :
81-13-0
BEILSTEIN REFERENCE NO. :
1724947
LAST UPDATED :
199701
DATA ITEMS CITED :
9
MOLECULAR FORMULA :
C9-H19-N-O4
MOLECULAR WEIGHT :
205.29
WISWESSER LINE NOTATION :
Q3MVYQX1&1&1Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
REFERENCE :
JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. Volume(issue)/page/year: 6(1),139,1987
TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
REFERENCE :
JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. Volume(issue)/page/year: 6(1),139,1987 ** ACUTE TOXICITY DATA **
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
15 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. Volume(issue)/page/year: 6(1),139,1987
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
9 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information, see FRMCE8 Volume(issue)/page/year: 14,43,1959
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
7 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 73,292,1950
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
4 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 73,292,1950 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80472 No. of Facilities: 1172 (estimated) No. of Industries: 7 No. of Occupations: 16 No. of Employees: 8069 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 80472 No. of Facilities: 2510 (estimated) No. of Industries: 4 No. of Occupations: 7 No. of Employees: 46519 (estimated) No. of Female Employees: 36944 (estimated)

 Safety Information

Personal Protective Equipment Eyeshields;Gloves
Hazard Codes Xn: Harmful;
Risk Phrases R36/37/38
Safety Phrases S24/25
RIDADR UN 2583 8/PG 2
WGK Germany 1
RTECS ES4316000
HS Code 2924199090

 Synthetic Route

~%

Dexpanthenol Structure

Dexpanthenol

CAS#:81-13-0

Literature: Barell-Festschr. S.86 US2413077 , ; CH227706 , ; CH239754 , ;

 Customs

HS Code 2924199090
Summary 2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

 Articles12

More Articles
Release of betaine and dexpanthenol from vitamin E modified silicone-hydrogel contact lenses.

Curr. Eye Res. 40(3) , 267-73, (2015)

To develop a contact lens system that will control the release of an osmoprotectant and a moisturizing agent with the aim to reduce symptoms of ocular dryness.Profiles of the release of osmoprotectant...

Cystoid macular oedema following Descemet membrane endothelial keratoplasty.

Br. J. Ophthalmol. 99(1) , 98-102, (2015)

To determine the incidence and potential risk factors of cystoid macular oedema (CMO) following Descemet membrane endothelial keratoplasty (DMEK) with or without simultaneous cataract surgery.In this ...

Characterization of a novel standardized human three-dimensional skin wound healing model using non-sequential fractional ultrapulsed CO2 laser treatments.

Lasers Surg. Med. 47(3) , 257-65, (2015)

At present, there is no standardized in vitro human skin model for wound healing. Therefore, our aim was to establish and characterize an in vitro/ex vivo three-dimensional (3D) wound healing model, w...

 Synonyms

Dexpanthenol
synapan
Ilopan
Cozyme
Panadon
Urupan
Proleus
D-pantothenyl alcohol
Intrapan
Motilyn
Pantol
MFCD00065006
Bepantol
Vitamin B5
D-panthenol
D-(+)-2,4-Dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutyramide
EINECS 201-327-3
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