Racecadotril

Modify Date: 2025-08-20 16:24:39

Racecadotril Structure
Racecadotril structure
 Common Name Racecadotril
CAS Number 81110-73-8 Molecular Weight 385.477
Density 1.2±0.1 g/cm3 Boiling Point 574.5±50.0 °C at 760 mmHg
Molecular Formula C21H23NO4S Melting Point 89ºC
MSDS Chinese USA Flash Point 301.2±30.1 °C
Symbol GHS07 GHS09
GHS07, GHS09		 Signal Word Warning

 Use of Racecadotril


Racecadotril (acetorphan), a potent enkephalinase inhibitor (IC50= 4.5 uM), protects endogenous enkephalins from degradation. IC50 value: 4.5 uMTarget: EnkephalinaseRacecadotril is a peripherally acting enkephalinase inhibitor with an IC50 of 4.5 uM. Unlike other medications used to treat diarrhea, which reduce intestinal motility, Racecadotril has an antisecretory effect-it reduces the secretion of water and electrolytes into the intestine. A small randomized controlled trial found Racecadotril to significantly reduce the duration and volume of watery diarrhea in children when given as an adjunct to oral rehydration therapy.

 Names

Name Racecadotril
Synonym More Synonyms

 Racecadotril Biological Activity

Description Racecadotril (acetorphan), a potent enkephalinase inhibitor (IC50= 4.5 uM), protects endogenous enkephalins from degradation. IC50 value: 4.5 uMTarget: EnkephalinaseRacecadotril is a peripherally acting enkephalinase inhibitor with an IC50 of 4.5 uM. Unlike other medications used to treat diarrhea, which reduce intestinal motility, Racecadotril has an antisecretory effect-it reduces the secretion of water and electrolytes into the intestine. A small randomized controlled trial found Racecadotril to significantly reduce the duration and volume of watery diarrhea in children when given as an adjunct to oral rehydration therapy.
Related Catalog
References

[1]. Marion Eberlin, Tobias Mück, Martin C. Michel, et al. A Comprehensive Review of the Pharmacodynamics, Pharmacokinetics, and Clinical Effects of the Neutral Endopeptidase Inhibitor Racecadotril. Front Pharmacol. 2012; 3: 93.

[2]. Wu HT, Chang CK, Cheng KC, et al. Increase of plasma insulin by racecadotril, an inhibitor of enkephalinase, in Wistar rats. Horm Metab Res. 2010 Apr;42(4):261-7.

[3]. Szajewska H, Ruszczyński M, Chmielewska A, Wieczorek J. Systematic review: racecadotril in the treatment of acute diarrhoea in children. Aliment Pharmacol Ther. 2007 Sep 15;26(6):807-13.

[4]. Schwartz JC. Racecadotril: a new approach to the treatment of diarrhoea. Int J Antimicrob Agents. 2000 Feb;14(1):75-9.

[5]. Racecadotril

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 574.5±50.0 °C at 760 mmHg
Melting Point 89ºC
Molecular Formula C21H23NO4S
Molecular Weight 385.477
Flash Point 301.2±30.1 °C
Exact Mass 385.134766
PSA 97.77000
LogP 3.44
Vapour Pressure 0.0±1.6 mmHg at 25°C
Index of Refraction 1.579
Storage condition Refrigerator

 Safety Information

Symbol GHS07 GHS09
GHS07, GHS09
Signal Word Warning
Hazard Statements H302-H400
Precautionary Statements P301 + P312 + P330
Hazard Codes Xn,N
Risk Phrases 22-50/53
Safety Phrases 60-61
RIDADR UN 3077 9 / PGIII
RTECS MB7606872
HS Code 2930909090

 Customs

HS Code 2930909090
Summary 2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

 Articles27

More Articles
A comparative study of racecadotril and single dose octreotide as an anti-secretory agent in acute infective diarrhoea.

J. Assoc. Physicians India 60 , 12-5, (2012)

To assess the efficacy of single dose of octreotide and compare it with another antisecretory agent racecadotril in the management of acute infective diarrhea.A randomized control study was done in th...

Racecadotril versus loperamide: antidiarrheal research revisited.

Dig. Dis. Sci. 48(2) , 239-50, (2003)

Racecadotril is an enkephalinase inhibitor, presented as a purely antisecretory agent with advantages over the opiate-receptor agonist loperamide in the treatment of diarrhea. A critical review of the...

Quantitative analysis of racecadotril metabolite in human plasma using a liquid chromatography/tandem mass spectrometry.

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 852(1-2) , 101-7, (2007)

Orally administered racecadotril is rapidly hydrolyzed to the more potent enkephalinase inhibitor thiorphan in vivo. A sensitive and specific liquid chromatography/tandem mass spectrometry method was ...

 Synonyms

Acetorphan
Tiorfan
Hidrasec
Tiorfix
Redotil
MFCD00865520
Benzyl N-[3-(acetylsulfanyl)-2-benzylpropanoyl]glycinate
Racecadotril
RACECADOTRIL: ACETORPHAN
RACECADORTRIL
Glycine, N-[3-(acetylthio)-1-oxo-2-(phenylmethyl)propyl]-, phenylmethyl ester
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Chemsrc provides Racecadotril(CAS#:81110-73-8) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Racecadotril are included as well.>> amp version: Racecadotril

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