2-Thiophenecarboxamide, 5-chloro-N-[(1R)-1-(methoxymethyl)-2-[[3-methyl-4-(3-oxo-4-morpholinyl)phenyl]amino]-2-oxoethyl]-

Modify Date: 2024-09-16 18:28:48

2-Thiophenecarboxamide, 5-chloro-N-[(1R)-1-(methoxymethyl)-2-[[3-methyl-4-(3-oxo-4-morpholinyl)phenyl]amino]-2-oxoethyl]- structure	Common Name	2-Thiophenecarboxamide, 5-chloro-N-[(1R)-1-(methoxymethyl)-2-[[3-methyl-4-(3-oxo-4-morpholinyl)phenyl]amino]-2-oxoethyl]-
	CAS Number	811811-33-3	Molecular Weight	451.92
	Density	1.393g/cm3	Boiling Point	786.902ºC at 760 mmHg
	Molecular Formula	C₂₀H₂₂ClN₃O₅S	Melting Point	N/A
	MSDS	N/A	Flash Point	429.703ºC

Use of 2-Thiophenecarboxamide, 5-chloro-N-[(1R)-1-(methoxymethyl)-2-[[3-methyl-4-(3-oxo-4-morpholinyl)phenyl]amino]-2-oxoethyl]-

EMD 495235 is a potent and orally active coagulation factor Xa inhibitor with an IC50 of 5.5 nM and a Ki of 6.8 nM. EMD 495235 shows anticoagulant activities[1].

Name	2-Thiophenecarboxamide, 5-chloro-N-[(1R)-1-(methoxymethyl)-2-[[3-methyl-4-(3-oxo-4-morpholinyl)phenyl]amino]-2-oxoethyl]

Description	EMD 495235 is a potent and orally active coagulation factor Xa inhibitor with an IC50 of 5.5 nM and a Ki of 6.8 nM. EMD 495235 shows anticoagulant activities[1].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Metabolic Enzyme/Protease >> Factor Xa
Target	IC50: 5.5 nM (factor Xa)[1]. Ki: 6.8 nM (human factor Xa)[1].
References	[1]. Werner W K R Mederski, et al. Chlorothiophenecarboxamides as P1 surrogates of inhibitors of blood coagulation factor Xa. Bioorg Med Chem Lett. 2004 Dec 6;14(23):5817-22.

Density	1.393g/cm3
Boiling Point	786.902ºC at 760 mmHg
Molecular Formula	C₂₀H₂₂ClN₃O₅S
Molecular Weight	451.92
Flash Point	429.703ºC
Exact Mass	451.09700
PSA	125.21000
LogP	2.98550
Index of Refraction	1.625

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