5'-O-DMT-2'-O-iBu-N-Bz-Guanosine

Modify Date: 2024-01-07 09:04:54

5'-O-DMT-2'-O-iBu-N-Bz-Guanosine Structure
5'-O-DMT-2'-O-iBu-N-Bz-Guanosine structure
Common Name 5'-O-DMT-2'-O-iBu-N-Bz-Guanosine
CAS Number 81279-39-2 Molecular Weight 769.95800
Density 1.25 Boiling Point N/A
Molecular Formula C41H51N5O8Si Melting Point N/A
MSDS N/A Flash Point N/A

 Use of 5'-O-DMT-2'-O-iBu-N-Bz-Guanosine


5'-O-DMT-2'-O-iBu-N-Bz-Guanosine could be used for silyl protection of ribonucleosides[1].

 Names

Name N-[9-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3-[tert-butyl(dimethyl)silyl]oxy-4-hydroxyoxolan-2-yl]-6-oxo-3H-purin-2-yl]-2-methylpropanamide
Synonym More Synonyms

 5'-O-DMT-2'-O-iBu-N-Bz-Guanosine Biological Activity

Description 5'-O-DMT-2'-O-iBu-N-Bz-Guanosine could be used for silyl protection of ribonucleosides[1].
Related Catalog
References

[1]. Thomas P Blaisdell, et al. Practical silyl protection of ribonucleosides. Org Lett. 2013 Sep 20;15(18):4710-3.

 Chemical & Physical Properties

Density 1.25
Molecular Formula C41H51N5O8Si
Molecular Weight 769.95800
Exact Mass 769.35100
PSA 159.31000
LogP 6.87400

 Safety Information

Hazard Codes Xi

 Synthetic Route

~61%

5'-O-DMT-2'-O-iBu-N-Bz-Guanosine Structure

5'-O-DMT-2'-O-i...

CAS#:81279-39-2

Literature: Wexselblatt, Ezequiel; Katzhendler, Jehoshua; Saleem-Batcha, Raspudin; Hansen, Guido; Hilgenfeld, Rolf; Glaser, Gad; Vidavski, Roee R. Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 12 p. 4485 - 4497

~74%

5'-O-DMT-2'-O-iBu-N-Bz-Guanosine Structure

5'-O-DMT-2'-O-i...

CAS#:81279-39-2

Literature: Blaisdell, Thomas P.; Lee, Sunggi; Kasaplar, Pinar; Sun, Xixi; Tan, Kian L. Organic Letters, 2013 , vol. 15, # 18 p. 4710 - 4713

~88%

5'-O-DMT-2'-O-iBu-N-Bz-Guanosine Structure

5'-O-DMT-2'-O-i...

CAS#:81279-39-2

Literature: Serebryany; Beigelman Nucleosides, nucleotides and nucleic acids, 2003 , vol. 22, # 5-8 p. 1007 - 1009

~%

5'-O-DMT-2'-O-iBu-N-Bz-Guanosine Structure

5'-O-DMT-2'-O-i...

CAS#:81279-39-2

Literature: Serebryany; Beigelman Nucleosides, nucleotides and nucleic acids, 2003 , vol. 22, # 5-8 p. 1007 - 1009

~%

5'-O-DMT-2'-O-iBu-N-Bz-Guanosine Structure

5'-O-DMT-2'-O-i...

CAS#:81279-39-2

Literature: Serebryany; Beigelman Nucleosides, nucleotides and nucleic acids, 2003 , vol. 22, # 5-8 p. 1007 - 1009

~%

5'-O-DMT-2'-O-iBu-N-Bz-Guanosine Structure

5'-O-DMT-2'-O-i...

CAS#:81279-39-2

Literature: Serebryany; Beigelman Nucleosides, nucleotides and nucleic acids, 2003 , vol. 22, # 5-8 p. 1007 - 1009

~%

5'-O-DMT-2'-O-iBu-N-Bz-Guanosine Structure

5'-O-DMT-2'-O-i...

CAS#:81279-39-2

Literature: Serebryany; Beigelman Nucleosides, nucleotides and nucleic acids, 2003 , vol. 22, # 5-8 p. 1007 - 1009

~%

5'-O-DMT-2'-O-iBu-N-Bz-Guanosine Structure

5'-O-DMT-2'-O-i...

CAS#:81279-39-2

Literature: Glaser, Gad; Katzhendler, Jehoshua; Hilgenfeld, Rolf; Vidavski, Roee; Wexselblatt, Ezequiel; Prez-Menahemov, Tamar; Kaspy, Ilana Patent: US2011/86813 A1, 2011 ;

 Synonyms

5'-dimethoxytrityl 2'-tert-butyldimethyl silyl N-isobutyrylguanosine
(2)N-isobutyryl-5'O-dimetoxytrityl-3'O-tert-butyldimethylsilyl guanosine
5'-O-DMT-2'-O-iBu-N-Bz-Guanosine
5'-O-DMT-N-isobutyryl-2'-O-TBDMS-guanosine
N2-isobutyryl-5'-O-(4,4'-dimethoxytrityl)-2'-O-tert-butyldimethylsilyl guanosine
N-(9-((2R,3R,4R,5R)-5-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-((tert-butyldimethylsilyl)oxy)-4-hydroxytetrahydrofuran-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)isobutyramide
2-N-isobutyryl-2'-O-tert-butyldimethylsilyl-5'-O-(4,4'-dimethoxytrityl)guanosine
5'-O-dimethoxytrityl-2'-O-tert-butyldimethylsilyl-N2-isobutyryl guanosine
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