NSC348884
Modify Date: 2024-01-11 01:00:49
NSC348884 structure
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Common Name | NSC348884 | ||
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| CAS Number | 81624-55-7 | Molecular Weight | 636.791 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 1001.7±65.0 °C at 760 mmHg | |
| Molecular Formula | C38H40N10 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 559.6±34.3 °C | |
Use of NSC348884NSC348884 is a nucleophosmin inhibitor disrupts oligomer formation and induces apoptosis, inhibits cell proliferation at an IC50 of 1.7-4.0 μM in distinct cancer cell lines.Target: nucleophosminin vitro: NSC348884 is a putative nucleophosmin small molecular inhibitor that disrupts a defined hydrophobic pocket required for oligomerization. NSC348884 disrupts nucleophosmin oligomer formation by native polyacrylamide gel electrophoresis assay. NSC348884 upregulates p53. NSC348884 induces apoptosis.[1] |
| Name | N,N,N',N'-tetrakis[(6-methyl-1H-benzimidazol-2-yl)methyl]ethane-1,2-diamine |
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| Synonym | More Synonyms |
| Description | NSC348884 is a nucleophosmin inhibitor disrupts oligomer formation and induces apoptosis, inhibits cell proliferation at an IC50 of 1.7-4.0 μM in distinct cancer cell lines.Target: nucleophosminin vitro: NSC348884 is a putative nucleophosmin small molecular inhibitor that disrupts a defined hydrophobic pocket required for oligomerization. NSC348884 disrupts nucleophosmin oligomer formation by native polyacrylamide gel electrophoresis assay. NSC348884 upregulates p53. NSC348884 induces apoptosis.[1] |
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| Related Catalog | |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 1001.7±65.0 °C at 760 mmHg |
| Molecular Formula | C38H40N10 |
| Molecular Weight | 636.791 |
| Flash Point | 559.6±34.3 °C |
| Exact Mass | 636.343750 |
| PSA | 121.20000 |
| LogP | 4.74 |
| Vapour Pressure | 0.0±0.3 mmHg at 25°C |
| Index of Refraction | 1.768 |
| Storage condition | 2-8°C |
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NSC348884 CAS#:81624-55-7 |
| Literature: US2008/221146 A1, ; Page/Page column 7-8 ; |
| Precursor 2 | |
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| DownStream 0 | |
| N,N,N',N'-Tetrakis[(6-methyl-1H-benzimidazol-2-yl)methyl]-1,2-ethanediamine |
| 1,2-Ethanediamine, N,N,N,N-tetrakis[(6-methyl-1H-benzimidazol-2-yl)methyl]- |
| NSC348884 |