81624-55-7
81624-55-7 structure
- Name: NSC348884
- Chemical Name: N,N,N',N'-tetrakis[(6-methyl-1H-benzimidazol-2-yl)methyl]ethane-1,2-diamine
- CAS Number: 81624-55-7
- Molecular Formula: C38H40N10
- Molecular Weight: 636.791
- Catalog: Signaling Pathways Apoptosis Apoptosis
- Create Date: 2018-12-31 13:01:27
- Modify Date: 2026-07-02 15:12:40
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NSC348884 is a nucleophosmin inhibitor disrupts oligomer formation and induces apoptosis, inhibits cell proliferation at an IC50 of 1.7-4.0 μM in distinct cancer cell lines.Target: nucleophosminin vitro: NSC348884 is a putative nucleophosmin small molecular inhibitor that disrupts a defined hydrophobic pocket required for oligomerization. NSC348884 disrupts nucleophosmin oligomer formation by native polyacrylamide gel electrophoresis assay. NSC348884 upregulates p53. NSC348884 induces apoptosis.[1]
| Name | N,N,N',N'-tetrakis[(6-methyl-1H-benzimidazol-2-yl)methyl]ethane-1,2-diamine |
|---|---|
| Synonyms |
NSC348884;NSC-348884;NSC
lymphoma,cancer,inhibit,SKOV3,MOSEC/Luc cell,NSC-348884,NSC 348884,LNCaP,doxorubicin,NSC348884,Inhibitor,ES2,small molecul,p53,Apoptosis 1,2-Ethanediamine, N1,N1,N2,N2-tetrakis[(6-methyl-1H-benzimidazol-2-yl)methyl] NSC 348884/NSC N1,N1,N2,N2-Tetrakis[(6-methyl-1H-benzimidazol-2-yl)methyl]-1,2-ethanediamine N,N,N',N'-Tetrakis[(6-methyl-1H-benzimidazol-2-yl)methyl]-1,2-ethanediamine NSC-348884 NSC348884 ，S8149 NSC348884, 10 mM in DMSO 1,2-EthanediaMine, N,N,N',N'-tetrakis[(5-Methyl-1H-benziMidazol-2-yl)Methyl]- (9CI) |
| Description | NSC348884 is a nucleophosmin inhibitor disrupts oligomer formation and induces apoptosis, inhibits cell proliferation at an IC50 of 1.7-4.0 μM in distinct cancer cell lines.Target: nucleophosminin vitro: NSC348884 is a putative nucleophosmin small molecular inhibitor that disrupts a defined hydrophobic pocket required for oligomerization. NSC348884 disrupts nucleophosmin oligomer formation by native polyacrylamide gel electrophoresis assay. NSC348884 upregulates p53. NSC348884 induces apoptosis.[1] |
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| Related Catalog | |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 1001.7±65.0 °C at 760 mmHg |
| Molecular Formula | C38H40N10 |
| Molecular Weight | 636.791 |
| Flash Point | 559.6±34.3 °C |
| Exact Mass | 636.343750 |
| PSA | 121.20000 |
| LogP | 4.74 |
| Vapour Pressure | 0.0±0.3 mmHg at 25°C |
| Index of Refraction | 1.768 |
| Storage condition | 2-8°C |
