(D-Ala2)-Leu-Enkephalin-Arg trifluoroacetate salt

Modify Date: 2024-01-05 12:22:35

(D-Ala2)-Leu-Enkephalin-Arg trifluoroacetate salt Structure
(D-Ala2)-Leu-Enkephalin-Arg trifluoroacetate salt structure
Common Name (D-Ala2)-Leu-Enkephalin-Arg trifluoroacetate salt
CAS Number 81733-79-1 Molecular Weight 725.83500
Density 1.363g/cm3 Boiling Point N/A
Molecular Formula C35H51N9O8 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of (D-Ala2)-Leu-Enkephalin-Arg trifluoroacetate salt


Dalargin is a potent δ-opioid receptor agonist. Dalargin mitigates Gentamicin (HY-A0276)-induced cell death. Dalargin shows nephroprotective effects on Gentamicin-induced kidney injury. Dalargin shows antiulcer activity[1][2][3].

 Names

Name (2S)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2R)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]-5-(diaminomethylideneamino)pentanoic acid
Synonym More Synonyms

  Biological Activity

Description Dalargin is a potent δ-opioid receptor agonist. Dalargin mitigates Gentamicin (HY-A0276)-induced cell death. Dalargin shows nephroprotective effects on Gentamicin-induced kidney injury. Dalargin shows antiulcer activity[1][2][3].
Related Catalog
Target

δ Opioid Receptor/DOR

In Vitro Dalargin (100 µg/mL; 1 h) 在体外减轻庆大霉素诱导的肾上皮细胞死亡[2]。 Cell Viability Assay[2] Cell Line: Kidney cells Concentration: 100 µg/mL Incubation Time: 1 h (prior to treatment with 1.2–2.5 mg/ml gentamicin for 24 h) Result: Reduced kidney cells death.
In Vivo Dalargin (25, 50 µg/kg; i.p.) 对庆大霉素诱导的大鼠肾损伤显示出肾脏保护作用[2]。 Animal Model: 290-350 g, White male rats[2] Dosage: 25, 50 µg/kg Administration: I.p. (3 h before each gentamicin injection) Result: Mitigated gentamicin-induced acutekidney injury, attenuated ROS generation and oxidative stress, alleviated histopathological changes in a renal tissue.
References

[1]. Titov MI, et al. Dalargin--a peptidnyĭ preparat s tsitoprotektivnym deĭstviem [Dalargin--a peptide preparation with cytoprotective action]. Biull Vsesoiuznogo Kardiol Nauchn Tsentra AMN SSSR. 1985;8(2):72-6.  

[2]. Plotnikov EY, et al. Nephroprotective effect of GSK-3β inhibition by lithium ions and δ-opioid receptor agonist dalargin on gentamicin-induced nephrotoxicity. Toxicol Lett. 2013 Jul 18;220(3):303-8.  

[3]. Polonskiĭ VM, et al. Mesto prilozheniia (tsentral'noe ili perifericheskoe) protivoiazvennogo deĭstviia sinteticheskogo analoga éndogennykh opioidov dalargina v éksperimental'noĭ modeli tsisteaminovykh duodenal'nykh iazv u krys [The site (central or peripheral) of the anti-ulcer action of dalargin, a synthetic analog of endogenous opioids in an experimental model of cysteamine-induced duodenal ulcer in rats]. Biull Eksp Biol Med. 1987 Apr;103(4):433-4.  

 Chemical & Physical Properties

Density 1.363g/cm3
Molecular Formula C35H51N9O8
Molecular Weight 725.83500
Exact Mass 725.38600
PSA 308.40000
LogP 5.06670

 Synonyms

Dalargin
H-Tyr-D-Ala-Gly-Phe-Leu-Arg-OH
(D-Ala2)-Leucine Enkephalin-Arg