Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2

Modify Date: 2024-01-13 18:31:03

Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2 Structure
Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2 structure
 Common Name Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2
CAS Number 82188-67-8 Molecular Weight 985.10
Density N/A Boiling Point N/A
Molecular Formula C47H64N14O10 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2


Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2 is a melanotropin, a melanocyte-stimulating hormone. Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2 stimulates tyrosinase and exhibits thermoregulatory effect in rats model[1][2].

 Names

Name Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2

 Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2 Biological Activity

Description Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2 is a melanotropin, a melanocyte-stimulating hormone. Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2 stimulates tyrosinase and exhibits thermoregulatory effect in rats model[1][2].
Related Catalog
In Vitro Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2 (0.1 pM-1 μM; 48 h) stimulates tyrosinase activity in a dose-dependent manner in Cloudman S91 mouse melanoma cells[1].
In Vivo Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2 (0-50 pM; i.c.v.; single dose) exerts thermoregulatory effect in rats model[2]. Animal Model: Rat model[2] Dosage: 0, 0.5, 1, 5, 10, or 50 pM peptide in 0.5 μL sterile saline Administration: Intracerebroventricular injection in the anterior hypothalamic-preoptic area (AHPOA) of rats; single dose; recorded 0, 10, 20, 30, 40, 50, and 60 min after injection Result: Showed greater difference than mean temperatures of animals receiving sterile saline group.
References

[1]. Marwan MM, et al. Stimulation of S91 melanoma tyrosinase activity by superpotent alpha-melanotropins. Mol Cell Endocrinol. 1985 Jul;41(2-3):171-7.

[2]. Lyn H, et al. α-Melanocyte-stimulating hormone (MSH) and [Nle4, D-Phe7]-α-MSH: Effects on core temperature in rats. Pharmacology Biochemistry and Behavior. 1993;44(3):533-538.

 Chemical & Physical Properties

Molecular Formula C47H64N14O10
Molecular Weight 985.10
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Chemsrc provides Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2(CAS#:82188-67-8) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2 are included as well.>> amp version: Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2

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