Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2
Modify Date: 2025-09-18 14:14:57
![Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2 Structure](https://image.chemsrc.com/caspic/174/82188-67-8.png)
Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2 structure
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Common Name | Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2 | ||
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| CAS Number | 82188-67-8 | Molecular Weight | 985.10 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C47H64N14O10 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2 is a melanotropin, a melanocyte-stimulating hormone. Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2 stimulates tyrosinase and exhibits thermoregulatory effect in rats model[1][2]. |
| Name | Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2 |
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| Description | Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2 is a melanotropin, a melanocyte-stimulating hormone. Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2 stimulates tyrosinase and exhibits thermoregulatory effect in rats model[1][2]. |
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| Related Catalog | |
| In Vitro | Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2 (0.1 pM-1 μM; 48 h) stimulates tyrosinase activity in a dose-dependent manner in Cloudman S91 mouse melanoma cells[1]. |
| In Vivo | Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2 (0-50 pM; i.c.v.; single dose) exerts thermoregulatory effect in rats model[2]. Animal Model: Rat model[2] Dosage: 0, 0.5, 1, 5, 10, or 50 pM peptide in 0.5 μL sterile saline Administration: Intracerebroventricular injection in the anterior hypothalamic-preoptic area (AHPOA) of rats; single dose; recorded 0, 10, 20, 30, 40, 50, and 60 min after injection Result: Showed greater difference than mean temperatures of animals receiving sterile saline group. |
| References |
| Molecular Formula | C47H64N14O10 |
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| Molecular Weight | 985.10 |
| InChIKey | ZHFBHJALAOQGNU-ZPRVLUMXSA-N |
| SMILES | CCCCC(NC(C)=O)C(=O)NC(CCC(=O)O)C(=O)NC(Cc1cnc[nH]1)C(=O)NC(Cc1ccccc1)C(=O)NC(CCCN=C(N)N)C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NCC(N)=O |