M1002

Modify Date: 2024-01-11 12:11:09

M1002 Structure
M1002 structure
Common Name M1002
CAS Number 823830-85-9 Molecular Weight 394.292
Density 1.6±0.1 g/cm3 Boiling Point 414.6±55.0 °C at 760 mmHg
Molecular Formula C15H8F6N2O2S Melting Point N/A
MSDS N/A Flash Point 204.6±31.5 °C

 Use of M1002


M1002 is a hypoxia-inducible factor-2 (HIF-2) agonist, and can enhance the expression of HIF-2 target genes. M1002 shows synergy with prolyl-hydroxylase domain (PHD) inhibitors[1].

 Names

Name N-[3,5-Bis(trifluoromethyl)phenyl]-1,2-benzothiazol-3-amine 1,1-dioxide
Synonym More Synonyms

 M1002 Biological Activity

Description M1002 is a hypoxia-inducible factor-2 (HIF-2) agonist, and can enhance the expression of HIF-2 target genes. M1002 shows synergy with prolyl-hydroxylase domain (PHD) inhibitors[1].
Related Catalog
In Vitro M1002 (10 μM; 24 h) enhances the expression of HIF-2 target genes with great efficacy[1]. M1002 (5 μM; 24 h) treatment shows synergy with prolyl hydroxylase domain (PHD) inhibitors[1]. RT-PCR[1] Cell Line: 786-O cells Concentration: 10 μM Incubation Time: 24 hours Result: Showed clear agonistic effects on the expression of HIF-2 target genes in 786-O cells as compared with the control. RT-PCR[1] Cell Line: Hep3B cells Concentration: 5 μM Incubation Time: 24 hours Result: Elevated the expression of EPO and NDRG1 by co-treatment of M1002 together with PHD inhibitors, compared with M1002 alone treatment.
References

[1]. Dalei Wu, et al. Bidirectional modulation of HIF-2 activity through chemical ligands. Nat Chem Biol. 2019 Apr;15(4):367-376.

 Chemical & Physical Properties

Density 1.6±0.1 g/cm3
Boiling Point 414.6±55.0 °C at 760 mmHg
Molecular Formula C15H8F6N2O2S
Molecular Weight 394.292
Flash Point 204.6±31.5 °C
Exact Mass 394.021057
LogP 5.15
Vapour Pressure 0.0±1.0 mmHg at 25°C
Index of Refraction 1.564

 Synonyms

1,2-Benzisothiazol-3-amine, N-[3,5-bis(trifluoromethyl)phenyl]-, 1,1-dioxide
MFCD05999002
N-[3,5-Bis(trifluoromethyl)phenyl]-1,2-benzothiazol-3-amine 1,1-dioxide