DCPIB

Modify Date: 2025-08-25 18:22:17

DCPIB Structure
DCPIB structure
 Common Name DCPIB
CAS Number 82749-70-0 Molecular Weight 427.36
Density 1.263g/cm3 Boiling Point 593.835ºC at 760 mmHg
Molecular Formula C22H28Cl2O4 Melting Point N/A
MSDS N/A Flash Point 312.94ºC

 Use of DCPIB


DCPIB is a selective, reversible and potent inhibitor of volume-regulated anion channels (VRAC), voltage-dependently activates potassium channels TREK1 and TRAAK, inhibits TRESK, TASK1 and TASK3 (IC50s, 0.14, 0.95, 50.72 μM, respectively)[1]. DCPIB is also a selective blocker of swelling-induced chloride current (ICl,swell), with an IC50 of 4.1 μM in CPAE cells[2].

 Names

Name 4-[(2-butyl-6,7-dichloro-2-cyclopentyl-1-oxo-3H-inden-5-yl)oxy]butanoic acid
Synonym More Synonyms

 DCPIB Biological Activity

Description DCPIB is a selective, reversible and potent inhibitor of volume-regulated anion channels (VRAC), voltage-dependently activates potassium channels TREK1 and TRAAK, inhibits TRESK, TASK1 and TASK3 (IC50s, 0.14, 0.95, 50.72 μM, respectively)[1]. DCPIB is also a selective blocker of swelling-induced chloride current (ICl,swell), with an IC50 of 4.1 μM in CPAE cells[2].
Related Catalog
Target

IC50：0.14 μM (TRESK), 0.95 μM (TASK1), 50.72 μM (TASK3)[1], 4.1 μM (ICl,swell, CPAE cells)[2]

References

[1]. Lv J, et al. DCPIB, an Inhibitor of Volume-Regulated Anion Channels, Distinctly Modulates K2P Channels. ACS Chem Neurosci. 2019 Apr 17.

[2]. Decher N, et al. DCPIB is a novel selective blocker of I(Cl,swell) and prevents swelling-induced shortening of guinea-pig atrial action potential duration. Br J Pharmacol. 2001 Dec;134(7):1467-79.

 Chemical & Physical Properties

Density 1.263g/cm3
Boiling Point 593.835ºC at 760 mmHg
Molecular Formula C22H28Cl2O4
Molecular Weight 427.36
Flash Point 312.94ºC
Exact Mass 426.13600
PSA 63.60000
LogP 6.34260
Index of Refraction 1.564
Storage condition 2-8℃

 Synonyms

dcpib
hms3268c07
The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.
Top Suppliers:I want be here

Get all suppliers and price by the below link:

DCPIB suppliers

Price: ￥1210/10 mM * 1 mL in DMSO

Reference only. check more DCPIB price

Related Compounds: More...
Ethyl 4-{[(5-hydroxy-6,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidin-6-yl)acetyl]amino}benzoate
1209574-98-0
methyl [(4E)-5-oxo-1-phenyl-4-(1-{[2-(trifluoromethyl)phenyl]amino}ethylidene)-4,5-dihydro-1H-pyrazol-3-yl]acetate
1374510-78-7
2-(5-amino-1-methyl-1H-pyrazol-3-yl)phenol
1266365-70-1
2-{[4,5-bis(4-methoxyphenyl)-4H-1,2,4-triazol-3-yl]sulfanyl}-N'-[(1E)-1-(2-hydroxyphenyl)ethylidene]acetohydrazide
406464-65-1
(2E)-3-(furan-2-yl)-2-[2-(4-methoxyphenyl)hydrazin-1-ylidene]-3-oxopropanal
330574-84-0
3-(1H-benzotriazol-1-yl)-N'-[(1E)-1-(4-hydroxyphenyl)ethylidene]propanehydrazide
326002-11-3
(E)-N'-(1-(2-hydroxyphenyl)ethylidene)-3-(naphthalen-1-yl)-1H-pyrazole-5-carbohydrazide
1285630-44-5
4-(2,4-dichlorophenyl)-8-methyl-2-(morpholin-4-yl)-1,4-dihydro-6H-pyrimido[1,2-a][1,3,5]triazin-6-one
929818-43-9
1-(2,2-Difluoroethyl)-4-(difluoromethyl)-3-methyl-1H-pyrazolo[3,4-b]pyridin-6(7H)-one
1018142-26-1
2-(1-methyl-1H-pyrazol-5-yl)-1H-benzimidazole
953072-02-1
Chemsrc provides DCPIB(CAS#:82749-70-0) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of DCPIB are included as well.>> amp version: DCPIB

Home | MSDS/SDS Database Search | Journals | Product Classification | Biologically Active Compounds | Selling Leads | About Us | Disclaimer

Copyright © 2024 ChemSrc All Rights Reserved