DCPIB

• 常用名: DCPIB
• 英文名: DCPIB
• CAS号: 82749-70-0
• 分子量: 427.36
• 密度: 1.263g/cm3
• 沸点: 593.835ºC at 760 mmHg
• 分子式: C₂₂H₂₈Cl₂O₄
• 熔点: N/A
• 闪点: 312.94ºC

DCPIB用途

DCPIB 是一种选择性、可逆、有效的体积调节性阴离子通道 (VRAC) 抑制剂,能够电压依赖性激活钾离子通道 TREK1 和 TRAAK,抑制 TRESK,TASK1 和 TASK3,IC50 值分别为 0.14,0.95,50.72 μM。DCPIB 同时抑制肿胀激活氯电流 (ICl,swell),在 CPAE 细胞中,IC50 值为 4.1 μM。

DCPIB名称

• 中文名: DCPIB
• 英文名: 4-[(2-butyl-6,7-dichloro-2-cyclopentyl-1-oxo-3H-inden-5-yl)oxy]butanoic acid

DCPIB生物活性

• 描述: DCPIB 是一种选择性、可逆、有效的体积调节性阴离子通道 (VRAC) 抑制剂,能够电压依赖性激活钾离子通道 TREK1 和 TRAAK,抑制 TRESK,TASK1 和 TASK3,IC50 值分别为 0.14,0.95,50.72 μM。DCPIB 同时抑制肿胀激活氯电流 (ICl,swell),在 CPAE 细胞中,IC50 值为 4.1 μM。
• 相关类别:
  信号通路 >> 跨膜转运 >> 氯离子通道
  研究领域 >> 神经疾病
  信号通路 >> 跨膜转运 >> 钾通道
• 靶点实验:

  IC50：0.14 μM (TRESK), 0.95 μM (TASK1), 50.72 μM (TASK3)[1], 4.1 μM (ICl,swell, CPAE cells)[2]

• 参考文献:

  [1]. Lv J, et al. DCPIB, an Inhibitor of Volume-Regulated Anion Channels, Distinctly Modulates K2P Channels. ACS Chem Neurosci. 2019 Apr 17.

  [2]. Decher N, et al. DCPIB is a novel selective blocker of I(Cl,swell) and prevents swelling-induced shortening of guinea-pig atrial action potential duration. Br J Pharmacol. 2001 Dec;134(7):1467-79.

DCPIB物理化学性质

• 密度: 1.263g/cm3
• 沸点: 593.835ºC at 760 mmHg
• 分子式: C₂₂H₂₈Cl₂O₄
• 分子量: 427.36
• 闪点: 312.94ºC
• 精确质量: 426.13600
• PSA: 63.60000
• LogP: 6.34260
• InChIKey: KHKGTPJPBOQECW-UHFFFAOYSA-N
• SMILES: CCCCC1(C2CCCC2)Cc2cc(OCCCC(=O)O)c(Cl)c(Cl)c2C1=O
• 折射率: 1.564
• 储存条件: 2-8℃

DCPIB靶点实验

查看更多实验

实验名称：Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident pro... 来源：NCGC 靶标：N/A External Id：SERCaMPGLuc-p1-antagonist

实验名称：Distribution coefficient (D %) between octanol and buffer of pH 7.4 来源：ChEMBL 靶标：N/A External Id：CHEMBL622287

实验名称：Discovery of Small Molecules to Inhibit Human Cytomegalovirus Nuclear Egress 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：HCMV UL50 External Id：HMS1262

实验名称：Activation of TREK1 (unknown origin) expressed in COS7 cells assessed as increase in ... 来源：ChEMBL 靶标：Potassium channel subfamily K member 2 External Id：CHEMBL3819805

实验名称：Agonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation... 来源：ChEMBL 靶标：Leukotriene B4 receptor 2 External Id：CHEMBL4839253

实验名称：Rescue cell viability in cybrid cells with a genetic mutation in complex 1 of the mit... 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：N/A External Id：HMS1315

实验名称：qHTS for Inhibitors of Polymerase Kappa 来源：NCGC 靶标：DNA polymerase kappa [Homo sapiens] External Id：PolK100

实验名称：Dissociation constant (pKa) (determined in 30% EtOH) 来源：ChEMBL 靶标：N/A External Id：CHEMBL634293

实验名称：Tocris HTS for Inhibitors of Aerobactin Synthetase lucA 来源：23265 External Id：IucA Pilot Assay Tocris Library

实验名称：In vitro inhibition of HCO3- stimulated swelling in cat cerebrocortical tissue slice 来源：ChEMBL 靶标：Felis catus External Id：CHEMBL658990

共16条，当前第1页，共2页

1

2

DCPIB英文别名

• dcpib
• hms3268c07