Quinacrine Dihydrochloride Dihydrate

Modify Date: 2026-07-11 19:01:10

Quinacrine Dihydrochloride Dihydrate structure	Common Name	Quinacrine Dihydrochloride Dihydrate
	CAS Number	83-89-6	Molecular Weight	399.96
	Density	1.156 g/cm3	Boiling Point	557.1ºC at 760 mmHg
	Molecular Formula	C₂₃H₃₀ClN₃O	Melting Point	247-250ºC
	MSDS	N/A	Flash Point	290.7ºC

Use of Quinacrine Dihydrochloride Dihydrate

Quinacrine (Acriquine) is an antimalarial and anti-cancer agent. Quinacrine also inhibits human aldehyde oxidase (IC50: 3.3 μM). Quinacrine has affinity for nucleic acids, and stains DNA and RNA in fixed cells (Ex/Em: 436/525 nm)[1][2][3][4][7].

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name	quinacrine
Synonym	More Synonyms

This table contains bioactivity, target information and biological‑assay experimental data of this compound.

Description	Quinacrine (Acriquine) is an antimalarial and anti-cancer agent. Quinacrine also inhibits human aldehyde oxidase (IC50: 3.3 μM). Quinacrine has affinity for nucleic acids, and stains DNA and RNA in fixed cells (Ex/Em: 436/525 nm)[1][2][3][4][7].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel Research Areas >> Cancer Research Areas >> Infection Research Areas >> Neurological Disease
In Vitro	Quinacrine 抑制人和兔醛氧化酶，IC50 分别为 3.3 μM 和 10 μM[2]。 Quinacrine 阻断电压依赖性钠通道 (IC50: 3.3 μM)[3]。 Quinacrine (100 μM) 也是一种 PLA2 抑制剂[4]。 Quinacrine (0-20 μM, 24 h) 抑制 SGC-7901 细胞的生长，并诱导细胞凋亡[7]。 Cell Viability AssayQuinacrine 抑制人和兔醛氧化酶，IC50 分别为 3.3 μM 和 10 μM[2]。 Cell Line: SGC-7901 cell Concentration: 0, 5, 10, 15, 20 μM Incubation Time: 24 h Result: Inhibited cell growth with an IC50 value of 16.18 μM.
In Vivo	Quinacrine (3-30 mg/kg，i.p.，每日一次，连续三天) 对甘油诱导的大鼠急性肾损伤具有保护作用[5]。 Quinacrine (2.5-10 mg/kg，i.p.，每天一次，连续八周) 对环孢菌素引起的大鼠肾毒性具有保护作用[6]。 Animal Model: Acute kidney injury rat model[5] Dosage: 3-30 mg/kg Administration: i.p. Result: Attenuated glycerol induced structural and functional changes in kidney.
References	[1]. Vogtherr M, et al. Antimalarial drug quinacrine binds to C-terminal helix of cellular prion protein. J Med Chem. 2003 Aug 14;46(17):3563-4. [2]. Pryde DC, et al. Aldehyde oxidase: an enzyme of emerging importance in drug discovery. J Med Chem. 2010 Dec 23;53(24):8441-60. [3]. McNeal ET, et al. [3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs. J Med Chem. 1985 Mar;28(3):381-8. [4]. Caro AA,et al. Role of phospholipase A2 activation and calcium in CYP2E1-dependent toxicity in HepG2 cells. J Biol Chem. 2003 Sep 5;278(36):33866-77. [5]. Al Asmari AK, et al. Protective effect of quinacrine against glycerol-induced acute kidney injury in rats. BMC Nephrol. 2017 Jan 28;18(1):41. [6]. al Khader A, et al. Quinacrine attenuates cyclosporine-induced nephrotoxicity in rats. Transplantation. 1996 Aug 27;62(4):427-35. [7]. Wu X, et al. Quinacrine Inhibits Cell Growth and Induces Apoptosis in Human Gastric Cancer Cell Line SGC-7901. Curr Ther Res Clin Exp. 2012 Feb;73(1-2):52-64.

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Density	1.156 g/cm3
Boiling Point	557.1ºC at 760 mmHg
Melting Point	247-250ºC
Molecular Formula	C₂₃H₃₀ClN₃O
Molecular Weight	399.96
Flash Point	290.7ºC
Exact Mass	399.20800
PSA	37.39000
LogP	6.04540
InChIKey	GPKJTRJOBQGKQK-UHFFFAOYSA-N
SMILES	CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12

This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AR7700000

CHEMICAL NAME :: Acridine, 6-chloro-9-((4-(diethylamino)-1-methylbutyl)amino)-2- methoxy-

CAS REGISTRY NUMBER :: 83-89-6

LAST UPDATED :: 199710

DATA ITEMS CITED :: 26

MOLECULAR FORMULA :: C23-H30-Cl-N3-O

MOLECULAR WEIGHT :: 400.01

WISWESSER LINE NOTATION :: T C666 BNJ EG IMY1&3N2&2 LO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1320 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 239 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 50 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 10 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 75 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 8 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - chicken

DOSE/DURATION :: 714 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - coma Lungs, Thorax, or Respiration - other changes

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intrauterine

DOSE :: 13600 ug/kg

SEX/DURATION :: female 1 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Maternal Effects - uterus, cervix, vagina

TYPE OF TEST :: Specific locus test

MUTATION DATA

TYPE OF TEST :: Unscheduled DNA synthesis

TEST SYSTEM :: Mammal - species unspecified Lymphocyte

DOSE/DURATION :: 1 umol/L

REFERENCE :: CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1969- Volume(issue)/page/year: 8,113,1974 *** REVIEWS *** TOXICOLOGY REVIEW 32XPAD "Teratology," Berry, C.L., and D.E. Poswillo, eds., New York, Springer, 1975 Volume(issue)/page/year: -,49,1975 TOXICOLOGY REVIEW ARVPAX Annual Review of Pharmacology. (Palo Alto, CA) V.1-15, 1961-75. For publisher information, see ARPTDI. Volume(issue)/page/year: 5,447,1965

This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.

Hazard Codes	Xn: Harmful;
Risk Phrases	R36/37/38

This table contains target information, in‑vitro & in‑vivo assay data for this compound.

Name: Primary qHTS assay for inhibitors of alpha-synuclein gene (SNCA) expression
Source: NCGC
External Id: SNCA-p-activity-luciferase

Name: Inhibition of rabbit aldehyde oxidase
Source: ChEMBL
Target: Aldehyde oxidase 1
External Id: CHEMBL1640081

Name: NOVARTIS: Antimalarial liver stage activity measured as reduction in Plasmodium yoeli...
Source: ChEMBL
Target: Plasmodium yoelii
External Id: CHEMBL1789906

Name: NOVARTIS: Antimalarial liver stage activity measured as a greater than 50% reduction ...
Source: ChEMBL
Target: Plasmodium yoelii
External Id: CHEMBL1789905

Name: Antioxidant activity assessed as trolox equivalent of ABTS radical scavenging activit...
Source: ChEMBL
Target: NON-PROTEIN TARGET
External Id: CHEMBL3242317

Name: Increase the activity of the Burkholderia fixLJ 2-component system
Source: ICCB-Longwood/NSRB Screening Facility, Harvard Medical School
Target: Burkholderia multivorans
External Id: HMS1625

Name: Cytotoxicity against human HepG2 cells assessed as cell viability after 48 hrs by ala...
Source: ChEMBL
Target: NON-PROTEIN TARGET
External Id: CHEMBL3878513

Name: Binding affinity to Ebola virus glycoprotein assessed as dissociation constant incuba...
Source: ChEMBL
Target: N/A
External Id: CHEMBL4622624

Name: Inhibition of mouse Ido2 transfected in HEK293T cells using L-tryptophan as substrate...
Source: ChEMBL
Target: Indoleamine 2,3-dioxygenase 2
External Id: CHEMBL2210856

Name: Primary qHTS for inhibitors of NSP2Pro chikungunya virus (CHIKV)
Source: NCGC
External Id: APP-Toga-CHIKV-nsp2-p

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This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

Quinacrine Dihydrochloride Dihydrate

2-methoxy-6-chloro-9-(1-methyl-4-diethylaminobutylamino)-acridine

2-methoxy-6-(trifluoromethyl)nicotinic acid

2-METHOXY-6-(TRIFLUOROMETHYL)-3-PYRIDINECARBOXYLIC ACID

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What English synonyms does quinacrine have?

A: English synonyms of quinacrine: Quinacrine Dihydrochloride Dihydrate, 2-methoxy-6-chloro-9-(1-methyl-4-diethylaminobutylamino)-acridine, 2-methoxy-6-(trifluoromethyl)nicotinic acid, 2-METHOXY-6-(TRIFLUOROMETHYL)-3-PYRIDINECARBOXYLIC ACID.

Q: What is the melting point of quinacrine?

A: Melting point of quinacrine is 247-250ºC.

Q: What is the SMILES notation of quinacrine?

A: SMILES notation of quinacrine is CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12.

Q: What is the molecular formula of quinacrine?

A: Molecular formula of quinacrine is C23H30ClN3O.

Q: What is the molecular weight of quinacrine?

A: Molecular weight of quinacrine is 399.96.

Q: What is the LogP of quinacrine?

A: LogP of quinacrine is 6.04540.

Q: What is the InChIKey of quinacrine?

A: InChIKey of quinacrine is GPKJTRJOBQGKQK-UHFFFAOYSA-N.

Q: What is the CAS number of quinacrine?

A: CAS number of quinacrine is 83-89-6.

Q: What is the English name of quinacrine?

A: The English name of quinacrine is quinacrine.

Q: What is the boiling point of quinacrine?

A: Boiling point of quinacrine is 557.1ºC at 760 mmHg.

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

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Quinacrine Dihydrochloride Dihydrate

Use of Quinacrine Dihydrochloride Dihydrate

Names