APD 668
Modify Date: 2025-08-22 07:58:35
APD 668 structure
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Common Name | APD 668 | ||
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| CAS Number | 832714-46-2 | Molecular Weight | 477.509 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 611.6±55.0 °C at 760 mmHg | |
| Molecular Formula | C21H24FN5O5S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 323.7±31.5 °C | |
Use of APD 668APD668 is a potent GPR119 agonist with EC50 of 2.7 nM and 33 nM for hGPR119 and ratGPR119 respectively..IC50 value: 2.7 nM (EC50) [1]Target: GPR119Chronic treatment withAPD668 showed for the first time that blood glucose and glycated hemoglobin (HbA1c) levels could be significantly reduced in Zucker Diabetic Fatty (ZDF) rats over several weeks of dosing. APD668 was the ?rst compound with thismechanism of action to be progressed into clinical development for the treatment of diabetes. |
| Name | Isopropyl 4-({1-[2-fluoro-4-(methylsulfonyl)phenyl]-1H-pyrazolo[3 ,4-d]pyrimidin-4-yl}oxy)-1-piperidinecarboxylate |
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| Synonym | More Synonyms |
| Description | APD668 is a potent GPR119 agonist with EC50 of 2.7 nM and 33 nM for hGPR119 and ratGPR119 respectively..IC50 value: 2.7 nM (EC50) [1]Target: GPR119Chronic treatment withAPD668 showed for the first time that blood glucose and glycated hemoglobin (HbA1c) levels could be significantly reduced in Zucker Diabetic Fatty (ZDF) rats over several weeks of dosing. APD668 was the ?rst compound with thismechanism of action to be progressed into clinical development for the treatment of diabetes. |
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| Related Catalog | |
| References |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 611.6±55.0 °C at 760 mmHg |
| Molecular Formula | C21H24FN5O5S |
| Molecular Weight | 477.509 |
| Flash Point | 323.7±31.5 °C |
| Exact Mass | 477.148224 |
| PSA | 124.89000 |
| LogP | 1.99 |
| Appearance of Characters | white solid |
| Vapour Pressure | 0.0±1.8 mmHg at 25°C |
| Index of Refraction | 1.658 |
| Storage condition | -20℃ |
| Isopropyl 4-({1-[2-fluoro-4-(methylsulfonyl)phenyl]-1H-pyrazolo[3,4-d]pyrimidin-4-yl}oxy)-1-piperidinecarboxylate |
| 1-Piperidinecarboxylic acid, 4-[[1-[2-fluoro-4-(methylsulfonyl)phenyl]-1H-pyrazolo[3,4-d]pyrimidin-4-yl]oxy]-, 1-methylethyl ester |
| APD 668 |
| APD668 |