APD668

• 常用名: APD668
• 英文名: APD 668
• CAS号: 832714-46-2
• 分子量: 477.509
• 密度: 1.5±0.1 g/cm3
• 沸点: 611.6±55.0 °C at 760 mmHg
• 分子式: C₂₁H₂₄FN₅O₅S
• 熔点: N/A
• 闪点: 323.7±31.5 °C

APD668用途

APD668是GPR119激动剂，对人GPR119和大鼠GPR119的EC50分别为2.7 nM和33 nM。

APD668名称

• 中文名: APD668
• 英文名: Isopropyl 4-({1-[2-fluoro-4-(methylsulfonyl)phenyl]-1H-pyrazolo[3 ,4-d]pyrimidin-4-yl}oxy)-1-piperidinecarboxylate

APD668生物活性

• 描述: APD668是GPR119激动剂,对人GPR119和大鼠GPR119的EC50分别为2.7 nM和33 nM。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> GPR119
  研究领域 >> 代谢疾病
• 参考文献:

  [1]. Semple G, et al. Discovery of fused bicyclic agonists of the orphan G-protein coupled receptor GPR119 with in vivo activity in rodent models of glucose control. Bioorg Med Chem Lett. 2011 May 15;21(10):3134-41.

APD668物理化学性质

• 密度: 1.5±0.1 g/cm3
• 沸点: 611.6±55.0 °C at 760 mmHg
• 分子式: C₂₁H₂₄FN₅O₅S
• 分子量: 477.509
• 闪点: 323.7±31.5 °C
• 精确质量: 477.148224
• PSA: 124.89000
• LogP: 1.99
• InChIKey: XTRUQJBVQBUKSQ-UHFFFAOYSA-N
• SMILES: CC(C)OC(=O)N1CCC(Oc2ncnc3c2cnn3-c2ccc(S(C)(=O)=O)cc2F)CC1
• 外观性状: white solid
• 蒸汽压: 0.0±1.8 mmHg at 25°C
• 折射率: 1.658
• 储存条件: -20℃

APD668靶点实验

查看更多实验

实验名称：Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (... 来源：NCGC External Id：IP6K1-p1

实验名称：Thermal Shift Assay. Domain: start/stop: M1-L298 来源：ChEMBL 靶标：Cyclin-dependent kinase 2 External Id：CHEMBL5062802

实验名称：Cytochrome P450 family 3 subfamily A member 4 (CYP3A4) small molecule antagonists: lu... 来源：NCGC External Id：CYP3A4437

实验名称：Cytochrome P450 family 2 subfamily D member 6 (CYP2D6) small molecule antagonists: lu... 来源：NCGC External Id：CYP2D6395

实验名称：Thermal Shift Assay. Domain: start/stop: M1-K294 来源：ChEMBL 靶标：Casein kinase I isoform delta External Id：CHEMBL5064328

实验名称：Cytochrome P450 family 2 subfamily C member 9 (CYP2C9) small molecule antagonists: lu... 来源：NCGC External Id：CYP2C9536

实验名称：Incucyte cell viability with HEK293T 来源：ChEMBL 靶标：HEK-293T External Id：CHEMBL5058565

实验名称：A screen for small molecules that modulate mitochondrial supercomplex formation 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：N/A External Id：HMS1482

实验名称：Thermal Shift Assay. Domain: start/stop: M1-K294 来源：ChEMBL 靶标：Casein kinase I isoform delta External Id：CHEMBL5063801

实验名称：Primary qHTS for Identification of Calcium Integrin Binding Protein 1 (CIB1) Competit... 来源：NCGC External Id：CIB1-p1-p2

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APD668英文别名

• Isopropyl 4-({1-[2-fluoro-4-(methylsulfonyl)phenyl]-1H-pyrazolo[3,4-d]pyrimidin-4-yl}oxy)-1-piperidinecarboxylate
• 1-Piperidinecarboxylic acid, 4-[[1-[2-fluoro-4-(methylsulfonyl)phenyl]-1H-pyrazolo[3,4-d]pyrimidin-4-yl]oxy]-, 1-methylethyl ester
• APD 668
• APD668