LTF4

Modify Date: 2024-01-11 11:32:00

LTF4 Structure
LTF4 structure
Common Name LTF4
CAS Number 83851-42-7 Molecular Weight 568.723
Density 1.2±0.1 g/cm3 Boiling Point 872.8±65.0 °C at 760 mmHg
Molecular Formula C28H44N2O8S Melting Point N/A
MSDS N/A Flash Point 481.6±34.3 °C

 Use of LTF4


Leukotriene F4 (LTF4), is a lipid that belongs to the Cysteinyl Leukotriene (CysTL) family[1]. Leukotriene F4 induces bronchoconstriction with an ED50 of 16 μg/kg[2]. The precursor of LTF4 is Leukotriene E4 (LTE4), which isformed from the action of a glutamyl transferase[1].

 Names

Name leukotriene F4
Synonym More Synonyms

 LTF4 Biological Activity

Description Leukotriene F4 (LTF4), is a lipid that belongs to the Cysteinyl Leukotriene (CysTL) family[1]. Leukotriene F4 induces bronchoconstriction with an ED50 of 16 μg/kg[2]. The precursor of LTF4 is Leukotriene E4 (LTE4), which isformed from the action of a glutamyl transferase[1].
Related Catalog
Target

Human Endogenous Metabolite

References

[1]. Reddanna P, et al. Carboxypeptidase A-catalyzed direct conversion of leukotriene C4 to leukotriene F4. Arch Biochem Biophys. 2003;413(2):158-163.

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 872.8±65.0 °C at 760 mmHg
Molecular Formula C28H44N2O8S
Molecular Weight 568.723
Flash Point 481.6±34.3 °C
Exact Mass 568.281860
PSA 212.55000
LogP 4.54
Vapour Pressure 0.0±0.6 mmHg at 25°C
Index of Refraction 1.563

 Synthetic Route

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LTF4 Structure

LTF4

CAS#:83851-42-7

Literature: Okuyama; Miyamoto; Shimoji; Konishi; Fukushima; Niwa; Arai; Toda; Hayashi Chemical and Pharmaceutical Bulletin, 1982 , vol. 30, # 7 p. 2453 - 2462

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LTF4 Structure

LTF4

CAS#:83851-42-7

Literature: Okuyama; Miyamoto; Shimoji; Konishi; Fukushima; Niwa; Arai; Toda; Hayashi Chemical and Pharmaceutical Bulletin, 1982 , vol. 30, # 7 p. 2453 - 2462

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LTF4 Structure

LTF4

CAS#:83851-42-7

Literature: Okuyama; Miyamoto; Shimoji; Konishi; Fukushima; Niwa; Arai; Toda; Hayashi Chemical and Pharmaceutical Bulletin, 1982 , vol. 30, # 7 p. 2453 - 2462

 Synonyms

(5S,6R,7E,9E,11Z,14Z)-6-{[(2S)-2-{[(4S)-4-Amino-4-carboxy-1-hydroxybutylidene]amino}-2-carboxyethyl]sulfanyl}-5-hydroxy-7,9,11,14-icosatetraenoic acid
L-γ-Glutamyl-S-[(4S,5R,6E,8E,10Z,13Z)-1-carboxy-4-hydroxy-6,8,10,13-nonadecatetraen-5-yl]-L-cysteine
D-Cysteine, L-γ-glutamyl-S-[(1R,2E,4E,6Z,9Z)-1-[(1S)-4-carboxy-1-hydroxybutyl]-2,4,6,9-pentadecatetraen-1-yl]-
L-Cysteine, L-γ-glutamyl-S-[(1R,2E,4E,6Z,9Z)-1-[(1S)-4-carboxy-1-hydroxybutyl]-2,4,6,9-pentadecatetraen-1-yl]-
LTF4
Leukotriene F4
7,9,11,14-Eicosatetraenoic acid, 6-[[(2S)-2-[[(4S)-4-amino-4-carboxy-1-hydroxybutylidene]amino]-2-carboxyethyl]thio]-5-hydroxy-, (5S,6R,7E,9E,11Z,14Z)-
L-γ-glutamyl-S-{(1R,2E,4E,6Z,9Z)-1-[(1S)-4-carboxy-1-hydroxybutyl]pentadeca-2,4,6,9-tetraen-1-yl}-L-cysteine
L-γ-Glutamyl-S-[(4S,5R,6E,8E,10Z,13Z)-1-carboxy-4-hydroxy-6,8,10,13-nonadecatetraen-5-yl]-D-cysteine
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