hexestrol structure
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Common Name | hexestrol | ||
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CAS Number | 84-16-2 | Molecular Weight | 270.366 | |
Density | 1.1±0.1 g/cm3 | Boiling Point | 399.5±22.0 °C at 760 mmHg | |
Molecular Formula | C18H22O2 | Melting Point | 186 °C | |
MSDS | Chinese USA | Flash Point | 181.6±16.9 °C | |
Symbol |
GHS08 |
Signal Word | Danger |
Use of hexestrolHexestrol is a nonsteroidal synthetic estrogen. Hexestrol can be used for the research of the diseases caused by estrogen deficiencym, and it also can increase the weight of cattle[1][2]. |
Name | hexestrol |
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Synonym | More Synonyms |
Description | Hexestrol is a nonsteroidal synthetic estrogen. Hexestrol can be used for the research of the diseases caused by estrogen deficiencym, and it also can increase the weight of cattle[1][2]. |
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Related Catalog | |
In Vivo | Hexestrol (3 and 6 mg/kg; i.p. once daily for 30 days) has a not significant influence in the ovaries from mice at the dose of 3 mg/kg[2]. Animal Model: Mus musculus (90-120 days, 25-50 g)[2] Dosage: 3, 6 mg/kg (adopted the same dose used to increase weight gain in cattle) Administration: I.p. once daily for 30 days Result: Numerous follicles in different stages of development were found at the dose of 3 mg/kg in the ovaries. Not detected the corpora lutea (CL) at the dose of 6 mg/kg. |
References |
Density | 1.1±0.1 g/cm3 |
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Boiling Point | 399.5±22.0 °C at 760 mmHg |
Melting Point | 186 °C |
Molecular Formula | C18H22O2 |
Molecular Weight | 270.366 |
Flash Point | 181.6±16.9 °C |
Exact Mass | 270.161987 |
PSA | 40.46000 |
LogP | 4.98 |
Vapour Pressure | 0.0±1.0 mmHg at 25°C |
Index of Refraction | 1.582 |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
MUTATION DATA
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Symbol |
GHS08 |
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Signal Word | Danger |
Hazard Statements | H350 |
Precautionary Statements | P201-P308 + P313 |
Personal Protective Equipment | Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges |
Hazard Codes | T: Toxic; |
Risk Phrases | 45 |
Safety Phrases | S53-S45 |
RIDADR | NONH for all modes of transport |
WGK Germany | 2 |
RTECS | SL0560850 |
Precursor 8 | |
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DownStream 6 | |
Steatohepatitis-inducing drugs trigger cytokeratin cross-links in hepatocytes. Possible contribution to Mallory-Denk body formation.
Toxicol. In Vitro 22(6) , 1511-9, (2008) Mallory-Denk bodies (MDB) are hepatocyte inclusions containing cytokeratin 8 (CK8) which can develop, along with other steatohepatitis lesions, in patients treated with amiodarone, perhexiline maleate... |
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Effects of hexestrol on mouse ovarian morphology and ovulation.
Maturitas 60(2) , 153-7, (2008) To analyze histological aspects of ovaries as well as the ovulation of adult mice treated with the anabolic agent hexestrol.Thirty adult mice were divided into three groups of 10 animals each: (GI) th... |
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Positive and negative discrimination of estrogen receptor agonists and antagonists using site-specific DNA recombinase fusion proteins.
Mol. Endocrinol. 12(8) , 1120-32, (1998) Activation of the estrogen receptor (ER) by hormone involves at least two steps. First, hormone binding initially relieves repression, a property imposed on ER in cis by its ligand-binding domain (EBD... |
Phenol, 4,4'-(1,2-diethyl-1,2-ethanediyl)bis- |
Phenol, 4,4'-(1,2-diethyl-1,2-ethanediyl)bis-, (R*,S*)- |
Synestrol |
meso-3,4-Bis-(4-hydroxy-phenyl)-hexan |
Hexoestrolum |
hexestrol |
Synthovo |
Hexron |
(R*,S*)-4,4'-(1,2-diethyl-1,2-ethanediyl)bis-phenol |
Extra-Plex |
Hexane, 3,4-bis(p-hydroxyphenyl)- |
Vitestrol |
Estronal |
Sinestrol |
Estrifar |
EINECS 201-518-1 |
4,4'-(3,4-Hexanediyl)diphenol |
MFCD00068996 |
(R*,S*)-4,4'-(1,2-Diethyl-1,2-ethanediyl)bisphenol |
4,4'-(1,2-Diethylethylene)diphenol |
meso-3,4-bis-(4-hydroxyphenyl)hexane |
Estra-Plex |
Phenol, 4,4'- (1,2-diethyl-1,2-ethanediyl)bis- |
4,4'-hexane-3,4-diyldiphenol |
γ,δ-Di(p-hydroxyphenyl)-hexane |