lamotrigine structure
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Common Name | lamotrigine | ||
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CAS Number | 84057-84-1 | Molecular Weight | 256.091 | |
Density | 1.6±0.1 g/cm3 | Boiling Point | 503.1±60.0 °C at 760 mmHg | |
Molecular Formula | C9H7Cl2N5 | Melting Point | 177-181°C | |
MSDS | Chinese USA | Flash Point | 258.1±32.9 °C | |
Symbol |
GHS06 |
Signal Word | Danger |
Use of lamotrigineLamotrigine(BW430C) is a novel anticonvulsant drug for inhibition of 5-HT and sodium channelTarget: Sodium ChannelLamotrigine stabilises presynaptic neuronal membranes by blockade of voltage-dependent sodium channels, thus preventing the release of excitatory neurotransmitters, particularly glutamate and aspartate [1]. In rat cerebral cortex tissue incubated with veratrine 10 mg/L, lamotrigine is twice as potent in inhibiting the release of glutamate and aspartate (ED 50 = 5.38 mg/L for each) than the release of GABA (ED50 = 11.2 mg/L), and is much less potent in inhibiting acetylcholine release (ED50 = 25.6 mg/L) when cortical slices is exposed to veratrine 75 mg/L. Basal glutamate release is unaffected [2]. Lamotrigine inhibits high-frequency sustained repetitive firing of sodium-dependent action potentials, indicating a direct effect on voltage-activated sodium channels [3]. Lamotrigine (Lamictal), a phenyltriazine derivative, is a well established anticonvulsant agent that has shown efficacy in the prevention of mood episodes in adult patients with bipolar I disorder. lamotrigine significantly delayed time to intervention for a depressive episode and showed limited efficacy in delaying time to intervention for a manic/hypomanic episode, compared with placebo. Lamotrigine is generally well tolerated [4]. |
Name | lamotrigine |
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Synonym | More Synonyms |
Description | Lamotrigine(BW430C) is a novel anticonvulsant drug for inhibition of 5-HT and sodium channelTarget: Sodium ChannelLamotrigine stabilises presynaptic neuronal membranes by blockade of voltage-dependent sodium channels, thus preventing the release of excitatory neurotransmitters, particularly glutamate and aspartate [1]. In rat cerebral cortex tissue incubated with veratrine 10 mg/L, lamotrigine is twice as potent in inhibiting the release of glutamate and aspartate (ED 50 = 5.38 mg/L for each) than the release of GABA (ED50 = 11.2 mg/L), and is much less potent in inhibiting acetylcholine release (ED50 = 25.6 mg/L) when cortical slices is exposed to veratrine 75 mg/L. Basal glutamate release is unaffected [2]. Lamotrigine inhibits high-frequency sustained repetitive firing of sodium-dependent action potentials, indicating a direct effect on voltage-activated sodium channels [3]. Lamotrigine (Lamictal), a phenyltriazine derivative, is a well established anticonvulsant agent that has shown efficacy in the prevention of mood episodes in adult patients with bipolar I disorder. lamotrigine significantly delayed time to intervention for a depressive episode and showed limited efficacy in delaying time to intervention for a manic/hypomanic episode, compared with placebo. Lamotrigine is generally well tolerated [4]. |
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Related Catalog | |
References |
Density | 1.6±0.1 g/cm3 |
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Boiling Point | 503.1±60.0 °C at 760 mmHg |
Melting Point | 177-181°C |
Molecular Formula | C9H7Cl2N5 |
Molecular Weight | 256.091 |
Flash Point | 258.1±32.9 °C |
Exact Mass | 255.007858 |
PSA | 90.71000 |
LogP | -0.19 |
Vapour Pressure | 0.0±1.3 mmHg at 25°C |
Index of Refraction | 1.706 |
Storage condition | 2-8°C |
Water Solubility | DMSO: 20 mg/mL at 60 °C, soluble |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
|
Symbol |
GHS06 |
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Signal Word | Danger |
Hazard Statements | H301 |
Precautionary Statements | P301 + P310 |
Personal Protective Equipment | Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges |
Hazard Codes | T: Toxic; |
Risk Phrases | R25 |
Safety Phrases | S45 |
RIDADR | UN 2811 6.1/PG 3 |
WGK Germany | 3 |
RTECS | XY5850700 |
Packaging Group | III |
Hazard Class | 6.1(b) |
HS Code | 2933699090 |
~82% lamotrigine CAS#:84057-84-1 |
Literature: ALEMBIC LIMITED Patent: WO2009/69073 A1, 2009 ; Location in patent: Page/Page column 3; 5 ; |
~% lamotrigine CAS#:84057-84-1 |
Literature: US4847249 A1, ; |
~% lamotrigine CAS#:84057-84-1 |
Literature: US6111101 A1, ; |
~% lamotrigine CAS#:84057-84-1 |
Literature: EP247892 B1, ; |
~76% lamotrigine CAS#:84057-84-1 |
Literature: Ulomskii; Shestakova; Deev; Rusinov; Chupakhin Russian Chemical Bulletin, 2005 , vol. 54, # 3 p. 726 - 732 |
~% lamotrigine CAS#:84057-84-1 |
Literature: Russian Chemical Bulletin, , vol. 54, # 3 p. 726 - 732 |
~% lamotrigine CAS#:84057-84-1 |
Literature: Russian Chemical Bulletin, , vol. 54, # 3 p. 726 - 732 |
~% lamotrigine CAS#:84057-84-1 |
Literature: Russian Chemical Bulletin, , vol. 54, # 3 p. 726 - 732 |
HS Code | 2933699090 |
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Summary | 2933699090 other compounds containing an unfused triazine ring (whether or not hydrogenated) in the structure。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:20.0% |
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Development and validation of a GC/MS method for the simultaneous determination of levetiracetam and lamotrigine in whole blood.
J. Pharm. Biomed. Anal. 102 , 25-32, (2014) A sensitive and accurate gas chromatography-mass spectrometric method was developed and validated for the simultaneous determination of levetiracetam and lamotrigine in whole blood. A solid-phase extr... |
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Lamictal |
Lamotrigin |
6-(2,3-Dichlorophenyl)-1,2,4-triazine-3,5-diamine |
EINECS 281-901-8 |
6-(2,3-Dichlorophenyl)-3-imino-3,4-dihydro-1,2,4-triazin-5-amine |
1,2,4-Triazin-5-amine, 6-(2,3-dichlorophenyl)-3,4-dihydro-3-imino- |
Crisomet |
Lamictal CD |
HYDROXYMETHYL PROGESTERONE |
6-O-TRITYL-1,2,3,4-TETRA-O-ACETYL-ALPHA-D-MANNOPYRANOSE |
BW 430C |
LAMOTRIGENE |
LAMOTRIGINE API |
MFCD00865333 |
LAMOTRIGINE / 6-(2,3-DICHLOROPHENYL)-1,2,4-TRIAZINE-3,5-DIAMINE |
Lamictal XR |
1,2,4-Triazine-3,5-diamine, 6-(2,3-dichlorophenyl)- |
LAMOTRIGINE-13C3 |
LAMOTRIGINE (10 MG ) |
Lamotrigina |
1,2,4-TRIAZINE-3,5-DIAMINE,6-(2,3-DICHLOROPHENYL)- |
Labileno |
Lamotriginum |
Lamotrigine |