2-((Azido-PEG8-carbamoyl)methoxy)acetic acid

Modify Date: 2024-01-05 10:18:32

2-((Azido-PEG8-carbamoyl)methoxy)acetic acid Structure
2-((Azido-PEG8-carbamoyl)methoxy)acetic acid structure
Common Name 2-((Azido-PEG8-carbamoyl)methoxy)acetic acid
CAS Number 846549-37-9 Molecular Weight 554.58800
Density N/A Boiling Point N/A
Molecular Formula C22H42N4O12 Melting Point N/A
MSDS Chinese USA Flash Point N/A
Symbol GHS07
GHS07
Signal Word Warning

 Use of 2-((Azido-PEG8-carbamoyl)methoxy)acetic acid


2-((Azido-PEG8-carbamoyl)methoxy)acetic acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name 2-[2-[2-[2-[2-[2-[2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethylamino]-2-oxoethoxy]acetic acid
Synonym More Synonyms

  Biological Activity

Description 2-((Azido-PEG8-carbamoyl)methoxy)acetic acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Molecular Formula C22H42N4O12
Molecular Weight 554.58800
Exact Mass 554.28000
PSA 202.71000
Storage condition 2-8°C

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H315-H319-H335
Precautionary Statements P261-P305 + P351 + P338
Personal Protective Equipment Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes Xi
Risk Phrases 36/37/38
Safety Phrases 25
RIDADR NONH for all modes of transport

 Synonyms

AmbotzPEG2015