Indazole-Cl structure
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Common Name | Indazole-Cl | ||
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CAS Number | 848142-62-1 | Molecular Weight | 260.68 | |
Density | N/A | Boiling Point | N/A | |
Molecular Formula | C13H9ClN2O2 | Melting Point | N/A | |
MSDS | Chinese USA | Flash Point | N/A | |
Symbol |
GHS07 |
Signal Word | Warning |
Use of Indazole-ClIndazole-Cl (Ind-Cl) is an Estrogen receptor (ER)-β-specific agonist with inflammatory effect. Indazole-Cl inhibits cyclooxygenase-2 exression reduction induced by hypoxia. And Indazole-Cl inhibits ROS production. Indazole-Cl also inhibits cell migration and invasion by hypoxia increased by hypoxia. Indazole-Cl is potent inhibitor of hypoxia-induced inflammation in vascular smooth muscle cells (VSMCs)[1]. |
Name | 3-chloro-2-(4-hydroxyphenyl)indazol-5-ol |
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Description | Indazole-Cl (Ind-Cl) is an Estrogen receptor (ER)-β-specific agonist with inflammatory effect. Indazole-Cl inhibits cyclooxygenase-2 exression reduction induced by hypoxia. And Indazole-Cl inhibits ROS production. Indazole-Cl also inhibits cell migration and invasion by hypoxia increased by hypoxia. Indazole-Cl is potent inhibitor of hypoxia-induced inflammation in vascular smooth muscle cells (VSMCs)[1]. |
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Related Catalog | |
Target |
COX-2 |
In Vitro | Indazole-Cl (0.1 μM;6 小时) 降低血管平滑肌细胞 (VSMC) 缺氧诱导的细胞内 ROS 水平[1]。 Indazole-Cl (10 μM;24 小时) 抑制 VSMC 中缺氧诱导的环氧合酶 (COX)-2 转录活性[1]。 Indazole-Cl (1 μM;24-72 小时) 可防止缺氧诱导的 VSMC 细胞迁移和侵袭[1]。 |
References |
Molecular Formula | C13H9ClN2O2 |
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Molecular Weight | 260.68 |
Exact Mass | 260.03500 |
PSA | 58.28000 |
LogP | 3.09010 |
In Silico Prediction of Human Sulfotransferase 1E1 Activity Guided by Pharmacophores from Molecular Dynamics Simulations.
J. Biol. Chem. 291 , 58-71, (2016) Acting during phase II metabolism, sulfotransferases (SULTs) serve detoxification by transforming a broad spectrum of compounds from pharmaceutical, nutritional, or environmental sources into more eas... |
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An ADIOL-ERβ-CtBP transrepression pathway negatively regulates microglia-mediated inflammation. Saijo K, Collier JG, Li AC, Katzenellenbogen JA, Glass CK.
Cell 4 , 584-95, (2011)
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Estrogen receptor transrepresses brain inflammation. Gosselin D, Rivest S.
Cell 4 , 495-7, (2011)
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