RY796 racemate

Modify Date: 2024-04-11 19:40:52

RY796 racemate Structure
RY796 racemate structure
Common Name RY796 racemate
CAS Number 854165-96-1 Molecular Weight 353.466
Density N/A Boiling Point N/A
Molecular Formula C21H27N3O2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of RY796 racemate


A novel potent, selective Kv2 channel inhibitor that potently inhibits Kv2.1 and Kv2.2 with IC50 of 0.14 and 0.09 uM, respectively; shows no significant activity against Kv1.2 and Kv7.1, and Cav channels; enhances GSIS in isolated wild-type (WT) mouse and human islets, but not in islets from Kv2.1(-/-) mice, enhances somatostatin release in isolated human and mouse islets.

 Names

Name RY796 racemate

 RY796 racemate Biological Activity

Description A novel potent, selective Kv2 channel inhibitor that potently inhibits Kv2.1 and Kv2.2 with IC50 of 0.14 and 0.09 uM, respectively; shows no significant activity against Kv1.2 and Kv7.1, and Cav channels; enhances GSIS in isolated wild-type (WT) mouse and human islets, but not in islets from Kv2.1(-/-) mice, enhances somatostatin release in isolated human and mouse islets.
References References 1. Herrington J, et al. Mol Pharmacol. 2011 Dec;80(6):959-64. 2. Li XN, et al. J Pharmacol Exp Ther. 2013 Feb;344(2):407-16. View Related Products by Target Potassium Channel

 Chemical & Physical Properties

Molecular Formula C21H27N3O2
Molecular Weight 353.466
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