5'-Fluoroindirubinoxime
Modify Date: 2024-04-03 19:37:20
5'-Fluoroindirubinoxime structure
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Common Name | 5'-Fluoroindirubinoxime | ||
|---|---|---|---|---|
| CAS Number | 861214-33-7 | Molecular Weight | 295.26800 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C16H10FN3O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of 5'-Fluoroindirubinoxime5'-Fluoroindirubinoxime (5’-FIO, compound 13), an Indirubin (HY-N0117) derivative, is a potent FLT3 inhibitor, with an IC50 of 15 nM[1]. |
| Name | (3E)-5-Fluoro-3-[(3Z)-3-(hydroxyimino)-1,3-dihydro-2H-indol-2-yli dene]-1,3-dihydro-2H-indol-2-one |
|---|---|
| Synonym | More Synonyms |
| Description | 5'-Fluoroindirubinoxime (5’-FIO, compound 13), an Indirubin (HY-N0117) derivative, is a potent FLT3 inhibitor, with an IC50 of 15 nM[1]. |
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| Related Catalog | |
| Target |
15 nM (FLT3)[1]. |
| In Vitro | 5'-Fluoroindirubinoxime (5’-FIO, compound 13) exhibits IC50 values of 1.53 μM and 1.27 μM for VEGFR2 and Aurora A, respectively[1]. 5'-Fluoroindirubinoxime (5’-FIO) exhibits IC50 values of 12.2 μM, 2.1 μM, 3.4 μM and 5.1 μM in A549, SNU-638, HT-1080 and RK3E-ras cancer cells, respectively. 5'-Fluoroindirubinoxime (5’-FIO) induces the apoptosis in RK3E-ras cells[2]. |
| In Vivo | 5'-Fluoroindirubinoxime (5’-FIO, 10 μmol/L/100 μL (~2.95 mg/mL) every other day beginning on day 6, S.C..) exhibits significant anti-tumor activity in rats[2]. Animal Model: Rat tumor model based RK3E-ras cells[2]. Dosage: S.C.. Administration: 10 μmol/L/100 μL (~2.95 mg/mL) every other day beginning on day 6. Result: Effectively inhibited tumor growth. |
| References |
| Molecular Formula | C16H10FN3O2 |
|---|---|
| Molecular Weight | 295.26800 |
| Exact Mass | 295.07600 |
| PSA | 77.21000 |
| LogP | 3.01600 |
| Hazard Codes | Xi |
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| MFCD18086923 |