5'-Fluoroindirubinoxime

Modify Date: 2024-04-03 19:37:20

5'-Fluoroindirubinoxime structure	Common Name	5'-Fluoroindirubinoxime
	CAS Number	861214-33-7	Molecular Weight	295.26800
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₆H₁₀FN₃O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of 5'-Fluoroindirubinoxime

5'-Fluoroindirubinoxime (5’-FIO, compound 13), an Indirubin (HY-N0117) derivative, is a potent FLT3 inhibitor, with an IC50 of 15 nM[1].

Name	(3E)-5-Fluoro-3-[(3Z)-3-(hydroxyimino)-1,3-dihydro-2H-indol-2-yli dene]-1,3-dihydro-2H-indol-2-one
Synonym	More Synonyms

Description	5'-Fluoroindirubinoxime (5’-FIO, compound 13), an Indirubin (HY-N0117) derivative, is a potent FLT3 inhibitor, with an IC50 of 15 nM[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Protein Tyrosine Kinase/RTK >> FLT3
Target	15 nM (FLT3)[1].
In Vitro	5'-Fluoroindirubinoxime (5’-FIO, compound 13) exhibits IC50 values of 1.53 μM and 1.27 μM for VEGFR2 and Aurora A, respectively[1]. 5'-Fluoroindirubinoxime (5’-FIO) exhibits IC50 values of 12.2 μM, 2.1 μM, 3.4 μM and 5.1 μM in A549, SNU-638, HT-1080 and RK3E-ras cancer cells, respectively. 5'-Fluoroindirubinoxime (5’-FIO) induces the apoptosis in RK3E-ras cells[2].
In Vivo	5'-Fluoroindirubinoxime (5’-FIO, 10 μmol/L/100 μL (~2.95 mg/mL) every other day beginning on day 6, S.C..) exhibits significant anti-tumor activity in rats[2]. Animal Model: Rat tumor model based RK3E-ras cells[2]. Dosage: S.C.. Administration: 10 μmol/L/100 μL (~2.95 mg/mL) every other day beginning on day 6. Result: Effectively inhibited tumor growth.
References	[1]. Choi SJ, et al. Indirubin derivatives as potent FLT3 inhibitors with anti-proliferative activity of acute myeloid leukemic cells. Bioorg Med Chem Lett. 2010 Mar 15;20(6):2033-7. [2]. Kim SA, et al. Antitumor activity of novel indirubin derivatives in rat tumor model. Clin Cancer Res. 2007 Jan 1;13(1):253-9.

Molecular Formula	C₁₆H₁₀FN₃O₂
Molecular Weight	295.26800
Exact Mass	295.07600
PSA	77.21000
LogP	3.01600

Hazard Codes	Xi

MFCD18086923

DC Chemicals Limited
China
Product Name: 5'-Fluoroindirubinoxime
Price: $500.0/100mg $900.0/250mg $1700.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 5'-Fluoro-1H,1'H-[2,3']biindolylidene-3,2'dione3-oxime
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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